READTHROUGH

作品数：8被引量：13H指数：2
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相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Quantitative Biology》《World Journal of Pediatrics》更多>>
相关基金：国家自然科学基金北京市自然科学基金更多>>
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Suppressor tRNA in gene therapy被引量：1
《Science China(Life Sciences)》2024年第10期2120-2131,共12页Jingjing Ruan Xiaoxiao Yu Huixia Xu Wenrui Cui Kaiye Zhang Chenyang Liu Wenlong Sun Xiaodan Huang Lei An Yue Zhang 
supported by the National Natural Science Foundation of China(82371861);Key R&D Program of Zhejiang(2024SSYS0020);Henan Province Key Research and Promotion Project(242102311023);the Starting Fund from Zhejiang University。
Suppressor tRNAs are engineered or naturally occurring transfer RNA molecules that have shown promise in gene therapy for diseases caused by nonsense mutations,which result in premature termination codons(PTCs)in codi...
关键词：suppressor tRNA PTC nonsense mutation READTHROUGH gene therapy 
Application of topical gentamicin ointment in the treatment of Nagashima-type palmoplantar keratosis in children with a nonsense mutation被引量：1
《Pediatric Investigation》2023年第3期163-167,共5页Shan Wang Zhou Yang Ying Liu Huan Zhang Zongyang Liu Xiaoling Wang Ying Li Haihong Liu Yonghong Yang Lin Ma 
Children’s Medicine Research Project of Beijing Children’s Hospital,Capital Medical University,Grant/Award Number:YZZD202002
Importance:Nagashima-type palmoplantar keratosis(NPPK)is a hereditary dermatosis mostly caused by a nonsense mutation in SERPINB7.Despite the increasing interest in readthrough gentamicin treatment of NPPK,clinical ev...
关键词：CHILDREN GENTAMICIN Nagashima-type palmoplantar keratosis Nonsense mutation Readthrough treatment 
Distinct roles of two SEC scaffold proteins,AFF1 and AFF4,in regulating RNA polymerase Ⅱ transcription elongation
《Journal of Molecular Cell Biology》2023年第8期15-27,共13页Zhuanzhuan Che Xiaoxu Liu Qian Dai Ke Fang Chenghao Guo Junjie Yue Haitong Fang Peng Xie Zhuojuan Luo Chengqi Lin 
supported by grants from the National Key R&D Program of China(2018YFA0800100 to C.L.,2018YFA0800103 to Z.L.);the National Natural Science Foundation of China(32030017 and 31970617 to C.L.,31970626 to Z.L.);Shenzhen Science and Technology Program(JCYJ20210324133602008 to C.L.,JCYJ20210324133601005 to Z.L.).
The super elongation complex(SEC)containing positive transcription elongation factor b plays a critical role in regulating transcription elongation.AFF1 and AFF4,two members of the AF4/FMR2 family,act as central scaff...
关键词：super elongation complex AFF1 AFF4 transcription elongation early termination readthrough transcription 
Distal nucleotides affect the rate of stop codon read-through被引量：1
《Quantitative Biology》2023年第1期44-58,共15页Luciana I.Escobar Andres M.Alonso Jorge R.Ronderos Luis Diambra 
LIE is funded by CONICET Ph.D.Fellowship.AMA and LD are researchers of CONICET(Argentina).JRR is Full Professor at the UNLP(Argentina).This work was supported by CONICET,Argentina(PIP2017-00059).
Background:A key step in gene expression is the recognition of the stop codon to terminate translation at the correct position.However,it has been observed that ribosomes can misinterpret the stop codon and continue t...
关键词：translational readthrough stop codons translational termination ribosomal density profiles nucleotide usage frequency 
Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72
《Cellular & Molecular Immunology》2022年第6期702-714,共13页Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang 
This work was supported by the National Natural Science Foundation of China(NSFC)(81788101,31870163,and 32100104);the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-022);the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB29010102);CAS Southest Asia Biodiversity Research Institute(151C53KYSB20210023);Beijing Natural Science Foundation(L192007);National Pathogen Resource Center,and State Key Laboratory Special Fund(2060204);Y.B.is supported by the NSFC Outstanding Young Scholars(31822055);Youth Innovation Promotion Association of the CAS(2017122 and Y2021034);Overseas Expertise Introduction Center for Discipline Innovation(“111 Center”)(BP0820029).
Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, w...
关键词：AIV infection TRT SSU72 NS1 Immune escape 
Application of topical gentamicin-a new era in the treatment of genodermatosis被引量：4
《World Journal of Pediatrics》2021年第6期568-575,共8页Shan Wang Zhou Yang Ying Liu Mu-Tong Zhao Juan Zhao Huan Zhang Zong-Yang Liu Xiao-Ling Wang Lin Ma Yong-Hong Yang 
supported by Children's Medicine Research Project of Beijing Children's Hospital,Capital Medical University(YZZD202002).
Background The clinical use of gentamicin always lies in its antimicrobial activity in the past as an aminoglycoside antibiotic.However,in the past decade,there were considerable interests in therapeutic approaches in...
关键词：Epidermolysis bullosa GENTAMICIN Nagashima-type palmoplantar keratosis Nonsense mutation READTHROUGH 
Molecular diversity of barley yellow dwarf virus-PAV from China and the Czech Republic被引量：2
《Journal of Integrative Agriculture》2020年第11期2736-2745,共10页May Oo KHINE Brozenka MICHAELA LIU Yan Jiban Kumar KUNDU WANG Xi-feng 
This research was supported by the Inter-Governmental S&T Cooperation Project of China(2016YFE0131000);the Research Program of the Ministry of Education,Youth and Sports of the Czech Republic(LTACH-17010).
Wheat yellow dwarf disease(BYD),caused by different species of barley/cereal yellow dwarf viruses(B/CYDVs),is one of the most serious cereal diseases in China and the Czech Republic.Because genetic diversity of the vi...
关键词：barley yellow dwarf virus-PAV coat protein(CP) readthrough protein(RTP) PHYLOGENY genetic diversity China the Czech Republic 
Cloning and expression of the Chinese wheat mosaic virus RNA2 coat protein read-through and 19 ku cysteine-rich domains and localization of these proteins被引量：5
《Chinese Science Bulletin》2002年第12期1019-1023,共5页XU Lei CHEN Jianping YE Rong ZHAO Xiuyun YU Shanqing 
This work was supported by the Zhejiang Provincial Natural Science Foundation (Grant Nos. 399421 and RC9604);the National Natural Science Foundation of China (Grant No. 399704820);a special grant for the Key Laboratory of Zhejiang Province (Grant No. 0
The 5’-terminal (RTn) and 3’-terminal (RTc) halves of the coat protein readthrough domain and the 19 ku cysteine-rich protein of Chinese wheat mosaic virus (CWMV) were amplified by RT-PCR, cloned and expressed in E....
关键词：CHINESE WHEAT mosaic virus coat protein READTHROUGH DOMAIN CYSTEINE-RICH DOMAIN prokaryotic expression localisation. 
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