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作品数:881被引量:544H指数:11
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相关机构:中国科学院东北大学东北师范大学中国人民解放军空军雷达学院更多>>
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Expanding the scope of mast cell disease:Does mast cell-derived TNF play a role in immune-mediated chronic illness and autoimmunity?
《Rheumatology & Autoimmunity》2024年第4期218-225,共8页Rachel da Silveira Gorman Iffath Unissa Syed 
Increasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness,yet diagnostic criteria for mast cell activation syndrome still focus predominantly on a solitary mediator,...
关键词:autoimmune disease chronic illness mast cells mast cell activation syndrome mitochondrial dysfunction tumor necrosis factor 
Expanding carbon neutrality strategies:Incorporating out-ofboundary emissions in city-level frameworks
《Environmental Science and Ecotechnology》2024年第4期145-153,共9页Zhe Zhang Mingyu Li Li Zhang Yunfeng Zhou Shuying Zhu Chen Lv Yixuan Zheng Bofeng Cai Jinnan Wang 
supported by the National Natural Science Foundation of China:An emission scenario-air quality modelbased study on the evaluation of“Dual Attainments”of Chinese city(Grant No.72074154);Research on the optimization of synergistic regional pathways under carbon emission peak and carbon neutrality goals(Grant No.72140004);Research on pathway optimization and implementation mechanism of synergistic control of GHGs and pollution for key regions(Grant No.72243008).
Cities are increasingly vital in global carbon mitigation efforts,yet few have specifically tailored carbon neutrality pathways.Furthermore,out-of-boundary indirect greenhouse gas(GHG)emissions,aside from those relate...
关键词:Greenhouse gas emissions Full-scope emission accounting Carbon neutrality pathway CITY-LEVEL 
Expanding role and scope of artificial intelligence in the field of gastrointestinal pathology
《Artificial Intelligence in Gastroenterology》2024年第2期10-19,共10页Muhammed Mubarak Rahma Rashid Fnu Sapna Shaheera Shakeel 
Digital pathology(DP)and its subsidiaries including artificial intelligence(AI)are rapidly making inroads into the area of diagnostic anatomic pathology(AP)including gastrointestinal(GI)pathology.It is poised to revol...
关键词:Gastrointestinal pathology Digital pathology Artificial intelligence Machine learning Deep learning Precision diagnostics 
Expanding the Scope of Multivariate Regression Approaches in Cross-Omics Research
《Engineering》2021年第12期1725-1731,共7页Xiaoxi Hu Yue Ma Yakun Xu Peiyao Zhao Jun Wang 
the National Key Research and Development Program of China(2018YFC2000500);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29020000);the National Natural Science Foundation of China(31771481 and 91857101);the Key Research Program of the Chinese Academy of Sciences(KFZD-SW-219),“China Microbiome Initiative.”。
Recent technological advancements and developments have led to a dramatic increase in the amount of high-dimensional data and thus have increased the demand for proper and efficient multivariate regression methods.Num...
关键词:Multivariate regression methods Reduced rank regression SPARSITY Dimensionality reduction Variable selection 
Expanding the scope of genome editing with SpG and SpRY variants in rice被引量:8
《Science China(Life Sciences)》2021年第10期1784-1787,共4页Jun Ren Xiangbing Meng Fengyue Hu Qing Liu Yuexuan Cao Huiying Li Changjie Yan Jiayang Li Kejian Wang Hong Yu Chun Wang 
supported by the National Transgenic Science and Technology Program(2019ZX08010-003);the Central Publicinterest Scientific Institution Basal Research Fund(Y2020XK17);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences.
Dear Editor,The clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9(CRISPR/Cas9)system,since it was excavated,has been rapidly developed and sparked a revolution in the genome editin...
关键词:Cas9 NUCLEASE RENDERING 
Expanding plant genome-editing scope by an engineered iSpyMacCas9 system that targets A-rich PAM sequences被引量:5
《Plant Communications》2021年第2期78-88,共11页Simon Sretenovic Desuo Yin Adam Levav Jeremy D.Selengut Stephen M.Mount Yiping Qi 
supported by startup funds from the University of Maryland,the National Science Foundation Plant Genome Research Program grant(award no.IOS-1758745);the Biotechnology Risk Assessment Grant Program competitive grant(award no.2018-33522-28789)from the U.S.Department of Agriculture.
The most popular CRISPR-SpCas9 systemrecognizes canonical NGG protospacer adjacent motifs(PAMs).Previously engineered SpCas9 variants,such as Cas9-NG,favor G-rich PAMs in genome editing.In this manuscript,we describe ...
关键词:plant genome editing iSpyMacCas9 PAM cytosine base editing adenine base editing 
Expanding base editing scope to near-PAMless with engineered CRISPR/Cas9 variants in plants被引量:6
《Molecular Plant》2021年第2期191-194,共4页Chengwei Zhang Yao Wang Feipeng Wang Si Zhao Jinling Song Feng Feng Jiuran Zhao Jinxiao Yang 
This work was supported by Beijing Academy of Agriculture&Forestry Sciences;The funding included Beijing Municipal Natural Science Foundation(6204041);the Beijing Scholars Program(BSP041).
Dear Editor,Base editors(BEs),including cytosine base editor(CBE)and adenine base editor(ABE),have been widely used to generate irreversible nucleotide substitution in plants and animals.However,their wide application...
关键词:BASE IRREVERSIBLE transformed 
Expanding the scope of CRISPR/Cas9-mediated genome editing in plants using an xCas9 and Cas9-NG hybrid^FA被引量:4
《Journal of Integrative Plant Biology》2020年第4期398-402,共5页Qingfeng Niu Siqun Wu Yansha Li Xiaoxuan Yang Ping Liu Yaping Xu Zhaobo Lang 
supported by the National Key Research and Development Program(2018YFD1000200)(Z.L.);Major Project of Transgenic Crops of China(2019ZX08010003-002-006)(Y.L.);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27040000)(Z.L.)。
The widely used Streptococcus pyogenes Cas9(SpCas9)requires NGG as a protospacer adjacent motif(PAM)for genome editing.Although Sp Cas9 is a powerful genome-editing tool,its use has been limited on the targetable geno...
关键词:CRISPR/Cas9 EDITING SPACER 
Expanding the Scope of CRISPR/Cpfl-Mediatec Senome Editing in Rice被引量:7
《Molecular Plant》2018年第7期995-998,共4页Shaoya Li Xin Zhang Wensheng Wang Xiuping Guo Zhichao wu Wenming Du Yunde Zhao Lanqin Xia 
Dear Editor The CRISPR/Cas gene editing system offers great potential for functional genomics in plants and crop improvement. The spec- ificity of Cas-directed DNA cleavage is strictly determined by a chimeric single ...
PUBLIC LIABILITY OF TRANSNATIONAL CORPORATIONS: AN ARGUMENT FOR EXPANDING THE SCOPE OF LIABILITY UNDER INTERNATIONAL LAW
《US-China Law Review》2012年第4期359-375,共17页Sudipto Sircar Kshitiz Karjee 
At the international level the concept of corporate liability is unfortunately vague, especially on the transnational liability of multinational corporations. There is, till date, no set of binding international princ...
关键词:跨国公司 企业责任 国际法 环境违法行为 法律责任 刑事责任 约束力 评估 
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