Increasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness,yet diagnostic criteria for mast cell activation syndrome still focus predominantly on a solitary mediator,...
supported by the National Natural Science Foundation of China:An emission scenario-air quality modelbased study on the evaluation of“Dual Attainments”of Chinese city(Grant No.72074154);Research on the optimization of synergistic regional pathways under carbon emission peak and carbon neutrality goals(Grant No.72140004);Research on pathway optimization and implementation mechanism of synergistic control of GHGs and pollution for key regions(Grant No.72243008).
Cities are increasingly vital in global carbon mitigation efforts,yet few have specifically tailored carbon neutrality pathways.Furthermore,out-of-boundary indirect greenhouse gas(GHG)emissions,aside from those relate...
Digital pathology(DP)and its subsidiaries including artificial intelligence(AI)are rapidly making inroads into the area of diagnostic anatomic pathology(AP)including gastrointestinal(GI)pathology.It is poised to revol...
the National Key Research and Development Program of China(2018YFC2000500);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29020000);the National Natural Science Foundation of China(31771481 and 91857101);the Key Research Program of the Chinese Academy of Sciences(KFZD-SW-219),“China Microbiome Initiative.”。
Recent technological advancements and developments have led to a dramatic increase in the amount of high-dimensional data and thus have increased the demand for proper and efficient multivariate regression methods.Num...
supported by the National Transgenic Science and Technology Program(2019ZX08010-003);the Central Publicinterest Scientific Institution Basal Research Fund(Y2020XK17);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences.
Dear Editor,The clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9(CRISPR/Cas9)system,since it was excavated,has been rapidly developed and sparked a revolution in the genome editin...
supported by startup funds from the University of Maryland,the National Science Foundation Plant Genome Research Program grant(award no.IOS-1758745);the Biotechnology Risk Assessment Grant Program competitive grant(award no.2018-33522-28789)from the U.S.Department of Agriculture.
The most popular CRISPR-SpCas9 systemrecognizes canonical NGG protospacer adjacent motifs(PAMs).Previously engineered SpCas9 variants,such as Cas9-NG,favor G-rich PAMs in genome editing.In this manuscript,we describe ...
This work was supported by Beijing Academy of Agriculture&Forestry Sciences;The funding included Beijing Municipal Natural Science Foundation(6204041);the Beijing Scholars Program(BSP041).
Dear Editor,Base editors(BEs),including cytosine base editor(CBE)and adenine base editor(ABE),have been widely used to generate irreversible nucleotide substitution in plants and animals.However,their wide application...
supported by the National Key Research and Development Program(2018YFD1000200)(Z.L.);Major Project of Transgenic Crops of China(2019ZX08010003-002-006)(Y.L.);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27040000)(Z.L.)。
The widely used Streptococcus pyogenes Cas9(SpCas9)requires NGG as a protospacer adjacent motif(PAM)for genome editing.Although Sp Cas9 is a powerful genome-editing tool,its use has been limited on the targetable geno...
Dear Editor The CRISPR/Cas gene editing system offers great potential for functional genomics in plants and crop improvement. The spec- ificity of Cas-directed DNA cleavage is strictly determined by a chimeric single ...
At the international level the concept of corporate liability is unfortunately vague, especially on the transnational liability of multinational corporations. There is, till date, no set of binding international princ...