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Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral
《Neuroscience Bulletin》2023年第5期774-792,共19页Yi Yan Mengye Zhu Xuezhong Cao Gang Xu Wei Shen Fan Li Jinjin Zhang Lingyun Luo Xuexue Zhang Daying Zhang Tao Liu 
This work was supported by the National Natural Science Foundation of China(81960216,81903595,81860216,and 32060186)and the Natural Science Foundation of Jiangxi Province(20202BABL206049 and 20202BAB216043).
The thalamocortical(TC)circuit is closely asso-ciated with pain processing.The hyperpolarization-activated cyclic nucleotide-gated(HCN)2 channel is predominantly expressed in the ventral posterolateral thalamus(VPL)th...
关键词：Neuropathic pain Thalamocortical circuit HCN2 channel OPTOGENETICS Electrophysiology 
Up-regulation of P2X7 Receptors Contributes to Spinal Microglial Activation and the Development of Pain Induced by BmK-I被引量：6
《Neuroscience Bulletin》2019年第4期624-636,共13页Jingjing Zhou Xiaoxue Zhang You Zhou Bin Wu Zhi-Yong Tan 
supported by grants from the National Natural Science Foundation of China (31571032 and 31771191);supported by an Indiana Spinal Cord and Brain Injury Research Fund grant from Indiana State Department of Health, USA (2017)
Previous work has demonstrated that the sensitization of spinal neurons and microglia is important in the development of pain behaviors induced by BmK I,a Na^+ channel activator and a major peptide component of the ve...
关键词：P2X7 receptor BMK I SPINAL dorsal horn Interleukin 1β Microglia BRILLIANT Blue G 
Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice被引量：33
《Neuroscience Bulletin》2019年第3期471-485,共15页Ai-Hua Liu Min Chu Yu-Ping Wang 
supported by Beijing Key Laboratory of Neuromodulation(BZ0098);the Precision Medicine Project of the Ministry of Science and Technology of China(2016YFC0904400)
Epilepsy is a chronic and severe neurological disorder that has negative effects on the autonomous activities of patients. Functionally, Trem2(triggering receptor expressed on myeloid cells-2) is an immunoglobulin rec...
关键词：Trem2 EPILEPSY NEURONAL apoptosis PI3K/Akt pathway OXIDATIVE stress 
Up-Regulation of Akt and Nav1.8 in BmK I-Induced Pain被引量：2
《Neuroscience Bulletin》2018年第3期539-542,共4页Guokun Zhou Yunlu Jiao You Zhou Shichao Qin Jie Tao Feng Jiang Zhi-Yong Tan Yong-Hua Ji 
supported by grants from the National Natural Science Foundation of China (31571032, 31771191, and 81402903);supported by an Indiana Spinal Cord and Brain Injury Research Fund grant (ISCBIRF2017)
Dear Editor,As the key contributor to the rising phase of action potentials in dorsal root ganglion（DRG）neurons,voltagegated sodium channels（VGSCs）are important in physiological and pathological pain conditions.Fo...
关键词：Akt In Up-Regulation of Akt and Nav1.8 in BmK I-Induced Pain 
Involvement of ERK1/2 and p38 MAPK in up-regulation of 14-3-3 protein induced by hydrogen peroxide preconditioning in PC12 cells
《Neuroscience Bulletin》2008年第4期244-250,共7页苏庆杰 陈小武 陈志斌 孙圣刚 
the National Natural Science Foundation of China (No. 30570627)
Objective To investigate the protective effects of hydrogen peroxide preconditioning （HPP） on the pheochromocytoma （PC12） cells treated with 1-methyl-4-phenylpyridinium （MPP^＋） and to explore the potential mech...
关键词：hydrogen peroxide preconditioning 14-3-3 protein ERK1/2 p38 mitogen-activated protein kinase PC12 cell 
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