This work was supported by the National Natural Science Foundation of China(No.82201576);Beijing Hospitals Authority Youth Programme(China)(No.QML20210804);Beijing Medical Research 2021-8;Key Laboratory of Alzheimer's Disease of Zhejiang Province of China(No.ZJAD-2021004 to YZ);the National Natural Science Foundation of China(No.82230043 to WS).
As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been im...
We thank Professor Wei Cheng(Dalian Medical University)for generously offering T47D,MCF7,ZR-75-1,and SK-BR-3 breast cancer cells and Professor WeiGuo Zhu(Peking University Health Science Center)for providing the full-length human Flag-CHD4,GFP-CHD4,and GST-CHD4 plasmids.
The estrogen signaling system is a crucial regulator of metabolicandphysiologicalprocesses.However,abnormal activation of estrogen signaling may play a role in breast cancer initiation and progression.Crucial to this ...
Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as ...
BmK I, purified from the venom of scorpion Buthus rnartensi Karsch (BmK), is a receptor site-3- specific modulator of voltage-gated sodium channels (VGSCs) and can induce pain-related behaviors in rats. The tetrod...
supported by grants from National Natural Science Foundation of China (No. 30700799, 81172803);Doctoral Fund of Ministry of Education of China (No. 20070487119);Natural Science Foundation of Hubei Province (No. 2007AD A201)
T cell immunoglobulin and mucin domain 3 (Tim-3) is well known to negatively regulate T cells responses, but its role in burn-induced T cells immune suppression remains unclear. In the present study, in order to ide...