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XBP1 splicing contributes to endoplasmic reticulum stress-induced human islet amyloid polypeptide up-regulation
《Genes & Diseases》2024年第5期350-359,共10页Yun Zhang Susan Lin Jing Yao Wantong Cai Huaqiu Chen Ailikemu Aierken Zhe Wang Weihong Song 
This work was supported by the National Natural Science Foundation of China(No.82201576);Beijing Hospitals Authority Youth Programme(China)(No.QML20210804);Beijing Medical Research 2021-8;Key Laboratory of Alzheimer's Disease of Zhejiang Province of China(No.ZJAD-2021004 to YZ);the National Natural Science Foundation of China(No.82230043 to WS).
As a pathological hallmark of type 2 diabetes mellitus(T2DM),islet amyloid is formed by the aggregation of islet amyloid polypeptide(IAPP).Endoplasmic reticulum(ER)stress interacts with IAPP aggregates and has been im...
关键词:b-cell function Endoplasmic reticulum stress Islet amyloid polypeptide Type 2 diabetes mellitus XBP1 
CHD4-induced up-regulation of ERα activity contributes to breast cancer progression
《Genes & Diseases》2024年第3期132-135,共4页Aman Sattout Xiaomin Yu Zhuo Sun Yanan Li Yulin Li Shujing Li Wei Huo Huijian Wu 
We thank Professor Wei Cheng(Dalian Medical University)for generously offering T47D,MCF7,ZR-75-1,and SK-BR-3 breast cancer cells and Professor WeiGuo Zhu(Peking University Health Science Center)for providing the full-length human Flag-CHD4,GFP-CHD4,and GST-CHD4 plasmids.
The estrogen signaling system is a crucial regulator of metabolicandphysiologicalprocesses.However,abnormal activation of estrogen signaling may play a role in breast cancer initiation and progression.Crucial to this ...
关键词:BREAST CANCER ERΑ 
Up-regulation of miR-197-3p contributes to vascular inflammatory
《中国循环杂志》2018年第S01期130-130,共1页Huijuan Zhu Laiyuan Wang Shufeng Chen Hongfan Li Bin Yang Dongfeng Gu 
Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as ...
关键词:CARDIOVASCULAR diseases microRNAs(miRNAs) CORONARY ARTERY disease(CAD) 
Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain被引量:3
《Acta Biochimica et Biophysica Sinica》2016年第2期132-144,共13页Pin Ye Liming Hua Yunlu Jiao Zhenwei Li Shichao Qin Jin Fu Feng Jiang Tong Liu Yonghua Ji 
BmK I, purified from the venom of scorpion Buthus rnartensi Karsch (BmK), is a receptor site-3- specific modulator of voltage-gated sodium channels (VGSCs) and can induce pain-related behaviors in rats. The tetrod...
关键词:PAIN voltage-gated sodium channel Nay1.8 BmK I 
Up-regulation of Tim-3 Expression Contributes to Development of Burn-induced T Cell Immune Suppression in Mice被引量:1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第5期642-651,共10页唐朝晖 余彦 邱文洪 张剑 杨想平 
supported by grants from National Natural Science Foundation of China (No. 30700799, 81172803);Doctoral Fund of Ministry of Education of China (No. 20070487119);Natural Science Foundation of Hubei Province (No. 2007AD A201)
T cell immunoglobulin and mucin domain 3 (Tim-3) is well known to negatively regulate T cells responses, but its role in burn-induced T cells immune suppression remains unclear. In the present study, in order to ide...
关键词:T cell immunoglobulin and mucin domain 3 T cells burn injury immune suppression 
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