DIMINAZENE

作品数:8被引量:8H指数:2
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相关领域:农业科学更多>>
相关作者:张颖冬更多>>
相关机构:中国药科大学南京医科大学更多>>
相关期刊:《Asian Pacific Journal of Tropical Medicine》《Journal of Biomedical Research》《Journal of Coastal Life Medicine》《Journal of Acute Disease》更多>>
相关基金:国家自然科学基金更多>>
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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo
《Asian Pacific Journal of Tropical Biomedicine》2024年第3期93-99,共7页Shimaa Abd El-Salam El-Sayed Mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk 
supported by Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia through the project number:ISP23-73.
Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in vivo.Methods:Bioinformatic analysis was performed using atom pair fingerprints.An i...
关键词:BABESIA Pyronaridine tetraphosphate Diminazene aceturate BABESIOSIS THEILERIA 
Diminazene对慢性脑低灌注大鼠脑内炎症反应影响及机制研究被引量:2
《临床神经病学杂志》2020年第4期300-304,共5页陆俊玲 薛晓 段瑞 张颖冬 
国家自然科学基金(81771140);江苏省医学创新团队:CXTDA(2017030)。
目的研究Diminazene(DIZE)对慢性脑低灌注(CCH)大鼠脑内炎症反应的影响及潜在机制。方法建立CCH大鼠模型,随机分为假手术组、CCH组、CCH+低剂量DIZE组(2 mg/kg)、CCH+高剂量DIZE组(10 mg/kg)。ELISA检测大鼠脑组织IL-1β、IL-12、IL-6、...
关键词:DIMINAZENE 慢性脑低灌注 血管性认知障碍 炎症 
Diminazene aceturate modified nanocomposite for improved efficacy in acute trypanosome infection被引量:1
《Journal of Acute Disease》2018年第1期36-42,共7页Oluwatosin Kudirat Shittu Shaba Yisa Aaron Mariam Damilola Oladuntoye Bashir Lawal 
Objective: To investigate the improved antitrypanocidal activity and toxicity of diminazene aceturate modified Nano drug in experimental rats. Methods: Aqueous leaf extract of Hyptis suaveolens was used to reduce gold...
关键词:Nano carrier Hyptissuaveolens POLYHYDROXYBUTYRATE Diminazeneaceturate TRYPANOSOMIASIS TOXICITY 
Changes in blood sugar levels of rats experimentally infected with Trypanosoma brucei and treated with imidocarb dipropionate and diminazene aceturate
《Journal of Coastal Life Medicine》2016年第1期21-23,共3页Nwoha Rosemary Ijeoma Ogechi Omamegbe Joseph Omalathebu 
Objective:To determine the effect of Trypanosoma brucei(T.brucei)on blood sugar level of infected rats.Methods:The experiment was done with 42 albino rats grouped into 3 groups of 14 members each.Group A was uninfecte...
关键词:Blood sugar Trypanosoma brucei Albino rats Imidocarb dipropionate Diminazene aceturate 
Effect of experimental single Ancylostoma caninum and mixed infections of Trypanosoma brucei and Trypanosoma congolense on the humoural immune response to anti-rabies vaccination in dogs
《Journal of Coastal Life Medicine》2015年第6期491-494,共4页Nwoha Rosemary Ijeoma Ogechi Anene Boniface Maduka 
Supported by the Tertiary Education Trust Fund(TETFUND)(Grant No.MOUAU/ETF/DO/40/VOL.1/59).
Objective:To determine the effect of Ancylostoma caninum(A.caninum)and trypanosome parasites on the immune response to vaccination in dogs in endemic environments.Methods:Sixteen dogs for the experiment were grouped i...
关键词:TRYPANOSOMES Antibody response Ancylostoma caninum Diminazene aceturate Mebendazol Antirabies vaccination 
In vitro activity and in vivo efficacy of a combination therapy of diminazene and chloroquine against murine visceral leishmaniasis被引量:3
《The Journal of Biomedical Research》2015年第3期214-223,共10页Samuel W.Mwololo Joshua M.Mutiso John C.Macharia Alain J.Bourdichon Michael M.Gicheru 
partly supported by BPM Bulk Medicine and Pharmaceuticals Production,TROPMED GMbH,Neuhofer Welche 48,D-19370 Parchtm,Germany,courtesy of Dr Alain J.Bourdichon
The present study evaluated the in vitro activity and in vivo efficacy of diminazene combined with chloroquine as a potential drug against Leishmania donovani. Amphotericin B was used as a positive control drug. In vi...
关键词:efficacy diminazene-chloroquine combination therapy Leishmania donovani visceral leishmaniasis BALB/c mice 
Effect of diminazene aceturate,levamisole and vitamin C combination therapy in rats experimentally infected with Trypanosoma brucei brucei被引量:3
《Asian Pacific Journal of Tropical Medicine》2014年第6期438-445,共8页Adieme Ijeoma Chekwube Ezeh Ikenna Onyema Ugochukwu Emmanuel Ikenna Romanus Chukwuduruo Ezeokonkwo 
Objective:To investigate the effect of diminazene aceturale(DA) alone or in combination with either levamisole and/or Vitamin C in albino rats experimentally infected with Trypanosoma brucei brucei.Methods:Thirty adul...
关键词:DIMINAZENE aceturate LEVAMISOLE VITAMIN C Therapy TRYPANOSOMA BRUCEI BRUCEI RATS 
Increasing doses of diminazene aceturate:adverse reproductive effects in female Wistar rats被引量:2
《Asian Pacific Journal of Tropical Medicine》2010年第11期887-889,共3页Oguejiofor CF Ochiogu IS Umeoduagu CJ 
Objective:To investigate the effects of comparatively high doses of diminazene aceturate on the reproductive performance of female rats in the early stage of pregnancy.Methods:After oestrus synchronisation and success...
关键词:Diminazene aceturate Fetal résorption Reproduction GESTATION LITTER Rat 
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