BACKGROUND Mast cell leukemia(MCL),a subtype of systemic mastocytosis(SM),is an extremely rare clinical entity characterized by a very poor prognosis.Chemotherapy,tyrosine kinase inhibitors,and allogeneic hematopoieti...
supported by a grant from the National Cancer Institute,USA(No.R03CA252818 to NN).
Introduction:Mastocytosis,a clonal proliferation of mast cells commonly involving the skin and bone marrow,has a varied clinical presentation ranging from cutaneous lesions to systemic disease.Cutaneous mastocytosis i...
This work is supported by National Natural Science Foundation of China(82160521);Natural Science Foundation of Ningxia Province(2018A0089);Key Research and Development Program of Ningxia Province(2019BEH03003).
PI3 kinases are important for KIT signaling and KIT mutants mediated cell transformation.In order to know the difference of PI3 kinase isoforms p110αand p110δin the signaling of wild-type KIT and the often occurred ...
To the Editor: We report a 27-year-old woman with a 2-month history of irregular uterine bleeding between periods. Blistering on the head was noted in the patient at the age of 2 months, and she gradually developed re...
Mastocytosis is a rare disease that causes its victims pains in the body, anaphylactic shocks and in some cases death. There is currently no cure for this disease but there are some medications taken to manage the sym...
Mastocytosis is a rare group of disorders with chronic and episodic mast cell release of mediators which can have systemic and cutaneous manifestations. Triggers of anaphylaxis include commonly used medications for an...
As recognition of mast cell(MC) involvement in a range of chronic inflammatory disorders has increased, diagnosticians' suspicions of MC activation disease(MCAD) in their chronically mysteriously inflamed patients hav...
We report a 43-year-old man who had been experiencing recurrent attacks of syncope for several years, and a search for the causes behind these lapses in consciousness was fruitless for many years. The patient was admi...
Mastocytosis is a rare skin condition which typically .manifests with or without accompanied systemic symptoms. Localized tissue mastocytosis is known as mastocytoma. A Mastocytoma localized to the vulva is an extreme...