supported by the grants from Shandong Natural Science Foundation(No.ZR2020MH206);Ministry of Science and Technology of China(No.2020YFA0803301);National Natural Science Foundation of China(Nos.31470769 and 82073061).
The oncoprotein transcription factor paired box 2(PAX2)is aberrantly expressed in cancers,but the underlying mechanism remains elusive.Prolyl hydroxylase 3(PHD3)hydroxylates the proline residue of HIFα,mediating HIF...
This work was supported by the NIH grants R01CA177910 and R01GM094777 to WW.
Oxygen is vital for most living organisms.During the course of evolution, animals have developed a highly conserved and elegant pathway to regulate oxygen sensing that converges on the heterodimeric transcription fact...
The hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway present in animals ranging from Caenorhabditis elegans to mammals.The pathway is crucial for oxygen homeostasis maintenance.Hypox...