GLOBOZOOSPERMIA

作品数：7被引量：83H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：龚斐更多>>
相关机构：中南大学安徽医科大学第一附属医院更多>>
相关期刊：《Asian Journal of Andrology》《Chinese Medical Journal》《Cell Research》更多>>
相关基金：国家重点基础研究发展计划国家自然科学基金更多>>
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Novel DPY19L2 variants in globozoospermic patients and the overcoming this male infertility被引量：10
《Asian Journal of Andrology》2019年第2期183-189,共7页Yong-Liang Shang Fu-Xi Zhu Jie Yan Liang Chen Wen-Hao Tang Sai Xiao Wei-Ke Mo Zhi-Guo Zhang Xiao-Jin He Jie Qiao Yun-Xia Cao Wei Li 
Globozoospermia has been reported to be a rare but severe causation of male infertility,which results from the failure of acrosome biogenesis and sperm head shaping.Variants of dpy-19-like 2(DPY19L2)are highly related...
关键词：DPY19L2 GLOBOZOOSPERMIA male INFERTILITY point mutation whole-exome SEQUENCING 
Intracytoplasmic Sperm Injection Fertilization Rate Does Not-Depend on the Proportion of Round-headed Sperm, Small acrosomal Sperm, or Morphologically Normal Sperm in Patients with Partial Globozoospermia被引量：3
《Chinese Medical Journal》2015年第12期1590-1595,共6页Ling-Ying Jiang Ling-Yun Yang Xiao-Mei Tong Hai-Yan Zhu Ya-Mei Xue Wen-Zhi Xu Yang Yang Song-Ying Zhang 
Background：Generally,intracytoplasmic sperm injection （ICSI） may be the preferable method to treat partial globozoospermia,but whether there exist some correlations between ICSI fertilization rate and the proportio...
关键词：Fertilization Rate GLOBOZOOSPERMIA Intracytoplasmic Sperm Injection In-vitro Fertilization Sperm Acrosome 
Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men被引量：5
《Asian Journal of Andrology》2015年第1期68-73,I0008,共7页Leyla Ounis Abdelali Zoghmar Charles Coutton Leila Rouabah Maroua Hachemil Delphine Martinez Guillaume Martinez Ines Bellil Douadi Khelifi Christophe Arnoult Julien Faure Sebti Benbouhedja Abdelkader Rouabah Pierre F Ray 
Klinefelter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests offered to infertile men. Analyses of aurora kinase C （AURKCj and DPY19L2 are now recommended for patients presenting...
关键词：aurora kinase C DPY19L2 GLOBOZOOSPERMIA intracytoplasmic sperm injection INFERTILITY macrozoospermia 
Atg7 is required for acrosome biogenesis during spermatogenesis in mice被引量：28
《Cell Research》2014年第7期852-869,共18页Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li 
The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosom...
关键词：acrosome biogenesis autolysosome AUTOPHAGY GLOBOZOOSPERMIA Atg7 
A newly discovered mutation in PICK1 in a human with globozoospermia被引量：24
《Asian Journal of Andrology》2010年第4期556-560,共5页Gang Liu Qiu-Wen Shi Guang-Xiu Lu 
Globozoospermia is a human infertility syndrome caused by spermatogenesis defects （OMIM 102530）. Acrosome plays an important role at the site of sperm-zonapellucida binding during the fertilization process. Thus, ma...
关键词：ACROSOME GLOBOZOOSPERMIA PICK1 
Proteome analysis of round-headed and normal spermatozoa by 2-D fluorescence difference gel electrophoresis and mass spectrometry被引量：9
《Asian Journal of Andrology》2009年第6期683-694,共12页Ting-Ting Liao Zhen Xiang Wen-Bing Zhu Li-Qing Fan 
Acknowledgment We thank Beijing Proteome Research Center, （Beijing, China） for its enthusiastic technological support and for the theory of 2-D DIGE. We also thank（Changsha, China） College of Life Sciences at Hunan Normal University for supporting the MS technology. Finally, we are very grateful to our collaborators for their help, as well as their valuable discussions and suggestions during the course of this work. This work was supported by two grants from the National Natural Science Foundation of China （NO. 30170480 and NO. 30470884）.
Globozoospermia is a severe form of teratozoospermia characterized by round-headed spermatozoa with an absent acrosome, an aberrant nuclear membrane and midpiece defects. Globozoospermia is diagnosed by the presence o...
关键词：differential protein GLOBOZOOSPERMIA mass spectrometry （MS） two-dimensional difference gel electrophoresis （2-D DIGE） 
Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia： case report被引量：9
《Asian Journal of Andrology》2008年第2期332-336,共5页Enver K. Dirican Ahmet Isik KubilayVicdan Eran Sozen Zekiye Suludere 
We report the successful outcome of intracytoplasmic sperm injection （ICSI） treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes we...
关键词：intracytoplasmic sperm injection SPERMATOZOA ACROSOME scanning electron microscopy 
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