ACROSOME

作品数：37被引量：119H指数：6
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相关机构：浙江大学杭州师范大学无锡市第九人民医院上海市第一妇婴保健院更多>>
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Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice
《Science China(Life Sciences)》2025年第3期777-792,共16页Yiling Zhou Chaofeng Tu Charles Coutton Jianan Tang Shixiong Tian Shuyan Tang Guillaume Martinez Dapeng Zhou Célia Tebbakh Jiaxiong Wang Raoudha Zouari Xuehai Zhou Selima Fourati Ben Mustapha Xuemei Wang Bangguo Wu Xinyan Geng Shuang Liu Li Jin Huijuan Shi Yue-Qiu Tan Pierre FRay Lingbo Wang Xiaoyu Yang Feng Zhang Chunyu Liu 
supported by the National Natural Science Foundation of China(32288101,32100480,32370654,82271638,32322017);the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);Shanghai Hospital Development Center Foundation(SHDC12023121);the outstanding Youth Foundation of Hunan Provincial Natural Science Foundation of China(2023JJ20080).
Asthenoteratozoospermia is a common cause of male infertility.To further define the genetic causes underlying asthenoteratozoospermia,we performed whole-exome sequencing in a cohort of Han Chinese men with asthenotera...
关键词：male infertility asthenoteratozoospermia MYCBPAP acrosome biogenesis MANCHETTE AXONEME 
Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice被引量：1
《Journal of Genetics and Genomics》2024年第10期1007-1019,共13页Dapeng Zhou Huan Wu Lingbo Wang Xuemei Wang Shuyan Tang Yiling Zhou Jiaxiong Wang Bangguo Wu Jianan Tang Xuehai Zhou Shixiong Tian Shuang Liu Mingrong Lv Xiaojin He Li Jin Hujuan Shi Feng Zhang Yunxia Cao Chunyu Liu 
This study was supported by the National Key Research and Development Program of China(2021YFC2701400 and 2023YFC2705600);the National Natural Science Foundation of China(32288101,32100480,32370654,82271639,32322017,and32200485).
Oligoasthenoteratozoospermia is an important factor affecting male fertility and has been found to be associated with genetic factors.However,there are stll a proportion of oligoasthenoteratozoospermia cases that cann...
关键词：Male fertility OLIGOASTHENOTERATOZOOSPERMIA MFSD6L ACROSOME ICSI 
Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice被引量：2
《Journal of Genetics and Genomics》2024年第4期407-418,共12页Yaling Wang Xueying Huang Guoying Sun Jingwen Chen Bangguo Wu Jiahui Luo Shuyan Tang Peng Dai Feng Zhang Jinsong Li Lingbo Wang 
supported by the National Key Research and Development Program of China(2021YFC2701400);in part by the National Natural Science Foundation of China(32000393 and 32288101).
During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful fertilization.Severe deformities in flagella caus...
关键词：Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) INFERTILITY Sperm motility Asthenoteratozoospermia Disease modeling 
WDR38,a novel equatorial segment protein,interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis
《Acta Biochimica et Biophysica Sinica》2023年第10期1561-1570,共10页Qiujie Gao Gang Liu Lihua Huang Yunfei Zhang Xinxing Zhang Xiaoyue Song Xiaowei Xing 
supported by the grants from the Clinical Medical Technology Innovation Guidance Project of Hunan Province(No.2021SK53716);the Graduate Student Independent Exploration Innovation Fund of Central South University(No.1053320215836).
The WD40-repeat containing(WDR)proteins are enriched in the testis and play important roles in spermatogenesis.In the present study,we investigate the expression profile of WDR38,a novel member of the WDR protein fami...
关键词：WDR38 RAB19 GM130 acrosome biogenesis equatorial segment 
Participation of the inositol 1,4,5-trisphosphategated calcium channel in the zona pellucida- and progesterone-induced acrosome reaction and calcium influx in human spermatozoa被引量：1
《Asian Journal of Andrology》2020年第2期192-199,共8页Ying-Ya Li Yan-Ping Jia Li-Yan Duan Kun-Ming Li 
This work was supported by grants from the National Natural Science Foundation of China(grant No.81671521);the Natural Science Foundation of Shanghai(grant No.16ZR1427200);the Western Medical Guidance Project of Science and Technology Commission of Shanghai Municipality(grant No.17411968000);the Project of Three-year Action Plan to Promote Clinical Skills and Innovation Capabilities in Municipal Hospitals(grant No.16CR3069B).
The acrosome reaction is a prerequisite for fertilization,and its signaling pathway has been investigated for decades.Regardless of the type of inducers present,the acrosome reaction is ultimately mediated by the elev...
关键词：ACROSOME REACTION human SPERMATOZOA inositol 1 4 5-trisphosphate zona pellucida PROGESTERONE 
Molecular Cloning and Putative Functions of KIFC1 for Acrosome Formation and Nuclear Reshaping during Spermiogenesis in Schlegel’s Japanese Gecko Gekko japonicus
《Asian Herpetological Research》2019年第3期170-182,共13页Shuangli HAO Liyue ZHANG Jun PING Xiaowen WU Jianrao HU YongpuZHANG 
supported by the Natural Sciences Foundation of China (31170376);Zhejiang Province Natural Science Foundation of China (LY16C030001; LY18C040005)
Spermiogenesis, occurring in the male testis, is a complicated and highly-ordered developmental process resulting in the production of fertile mature sperm. In Gekko japonicus, this process occurs in 7 steps during wh...
关键词：SPERMIOGENESIS KIFC1 KINESIN Gekko JAPONICUS 
Nanotechnology-based approach for safer enrichment of semen with best spermatozoa被引量：3
《Journal of Animal Science and Biotechnology》2019年第2期390-401,共12页Casey L.Durfey Sabrina E.Swistek Shengfa F.Liao Mark A.Crenshaw Henry J.Clemente Rooban V.K.G.Thirumalai Christy S.Steadman Peter L.Ryan Scott T.Willard Jean M.Feugang 
supported by the USDA-ARS Biophotonics(grant#58–6402–3-018);the Undergraduate Research Scholar Program of the College of Agriculture and Life Sciences(CALS)and Mississippi Agricultural and Forestery Experiment Station(MAFES)
Background: Advances in nanotechnology have permitted molecular-based targeting of cells through safe and biocompatible magnetic nanoparticles(MNP). Their use to detect and remove damaged spermatozoa from semen doses ...
关键词：ACROSOME reaction Apoptosis Artificial INSEMINATION BOAR Iron oxide nanoparticles Nanopurification Nanoselection NANOTECHNOLOGY Reproduction Swine 
Prediction of protein structure of novel protein (116 kDa) from human sperm membrane
《Asian pacific Journal of Reproduction》2018年第3期136-138,共3页Umie Lestari Widodo Sutiman Bambang Sumitro 
Objective:To predict the protein similarity, biological function and structure of 116 kDa protein that was isolated from human sperm membrane of acrosome by usingin silico. Methods:Predictions for 116 kDa protein simi...
关键词：116kDa PROTEIN ACROSOME BIOCHEMICAL PROPERTIES CDH23 PROTEIN Human SPERM MEMBRANE 
Effects of penicillamine, hypotaurine, and epinephrine on motility, hyperactivity, acrosome reaction of fresh ram sperm
《Asian pacific Journal of Reproduction》2017年第6期283-288,共6页K.H.El-Shahat M.I.Taysser M.R.Badr K.A.Zaki 
Objective:To determine the effects of different concentrations of penicillamine, hypotaurine, and epinephrine (PHE) as well as incubation time on motility, hyperactivity and acrosome reaction (AR) of ram spermin vitro...
关键词：RAM SPERM Capcitation HYPERACTIVATION ACROSOME reaction PHE VF 
Acetyl-L-carnitine:An Effective Antioxidant against Cryo-damage on Human Spermatozoa with Asthenospermia被引量：7
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2017年第6期915-921,共7页邹宇洁 杨菁 常硕 徐望明 尹太郎 龙文 
supported by grants from the Natural Science Foundation of Hubei Province(No.2016CFB352);Hubei Province Health and Family Planning Scientific Research Project(No.WJ2017M011);China Scholarship Council(No.201706275124)
A variety of natural and artificial cryoprotectant extenders have been explored to enhance sperm recovery following cryopreservation-thawing process. The current investigation is aimed at evaluating the effect of acet...
关键词：acetyl-L-carnitine human spermatozoa DNA damage acrosome integrity 
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