HYPERACTIVATION

作品数：20被引量：54H指数：4
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相关领域：医药卫生生物学更多>>
相关机构：南开大学更多>>
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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis
《Science China(Life Sciences)》2025年第1期103-115,共13页Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang Qiu Guoqing Wang 
supported by the National Key Research and Development Program of China(2022YFF1203204);the National Natural Science Foundation of China Joint Fund for Regional Innovation and Development(U23A20269).
The coronavirus disease 2019(COVID-19)outbreak caused by the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)developed into a global health emergency.Systemic microthrombus caused by SARS-CoV-2 infection is...
关键词：SARS-CoV-2 cardiac microthrombosis immune hyperactivation cell competition 
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
《Cellular & Molecular Immunology》2024年第12期1522-1534,共13页Yunzhu Chen Baiwen Chen Jingyu Li Haixin Li Gaoyang Wang Xuemin Cai Qianqian Zhang Xiaoxu Liu Chen Kan Lei Wang Zhengting Wang Hua-Bing Li 
supported by the National Natural Science Foundation of China(No.82325024,82341017,82350112,82030042 and 32070917 to H.-B.L.);the Ministry of Science and Technology of China(No.2021YFA1100800 to H.-B.L.);the Shanghai Municipal Health Commission(No.2022XD047 and 2022JC001 to H.-B.L.).
Macrophage hyperactivation is a hallmark of inflammatory diseases,yet the role of alternative polyadenylation(APA)of mRNAs in regulating innate immunity remains unclear.In this study,we focused on 3’UTR-APA and demon...
关键词：alternative polyadenylation Nudt21 MACROPHAGE AUTOPHAGY INFLAMMATION 
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia cos-tus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation
《Chinese Journal of Natural Medicines》2024年第11期1011-1019,共9页XIAO Longgao ZHAO Yueqin DING Xiao LIU Hui ZHU Guangyu LI Yanxi YAN Huan FANG Xin ZHAO Yuhan LIU Haiyang 
supported by Yunnan RevitalizationTalentSupport Program“Top Team”Project(No.202305AT350001);“Young Talent”Project(No.YNQR-QNRC-2019-091);the National Natural Science Foundation of China(Nos.32170408,32000280,and 32000548);the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents(No.YNWR-CYJS-2019-011);the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform(No.2022YKZY001);the CAS Pioneer Hundred Talents Program,the Training of Technological Innovation Talents of Yunnan Province(No.202305AD160009);the Special Research Assistant of Chinese Academy of Sciences(No.E3292211Q1);the Young Academic and Technical Leader Raising Foundation of Yunnan Province(No.202005AC160035).
Three novel sesquiterpenoid heterodimers,designated as auckcostusolides A-C(1-3),were isolated from Aucklandia costus leaves.The structures of compounds 1-3 were elucidated through comprehensive spectroscopic analysis...
关键词：Aucklandia costus Sesquiterpenoid heterodimers Auckcostusolides A-CParaptosis MAPK signaling pathway 
Targeting complement hyperactivation:a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection
《Signal Transduction and Targeted Therapy》2024年第1期51-54,共4页Leili Jia Haihua Luo Lizhong Li Mingyao Wang Jiangfeng Liu Yuan Liang Shan Li Yong Jiang Juntao Yang Hongbin Song 
supported by grants from the National Key Research and Development Program of China(Nos.2018YFC1200100,2016YFC1200905);National Key Technology R&D Program of China(No.2017ZX10104001);National Natural Science Foundation of China(Nos.30801004,81371807);NSFC-Guangdong Joint Foundation of China(No.U1601225);Beijing Municipal Natural Science Foundation(No.7122132);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-044);the National College Students Innovation and Entrepreneurship Training Program of China(No.2023zglc06011).
Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fat...
关键词：INFLUENZA PNEUMONIA LUNG 
Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis
《Signal Transduction and Targeted Therapy》2024年第1期308-325,共18页Adilson Fonseca Teixeira Yanhong Wang Josephine Iaria Peter ten Dijke Hong-Jian Zhu 
Research on TGF-βsignaling was supported by the Australia’s National Health and Medical Research Council(NHMRC)(H-JZ),Friends of the Royal Melbourne Hospital Neurosciences Foundation(H-JZ),and the Cancer Genomics Centre Netherlands(CGC.NL)(PtD);AFT and YW were supported by the Melbourne Research Scholarship。
Metastasis is the leading cause of cancer-related deaths.Transforming growth factor beta(TGF-β)signaling drives metastasis and is strongly enhanced during cancer progression.Yet,the use of on-target TGF-βsignaling i...
关键词：METASTASIS doses INVASION 
Repression of interferon regulatory factor-4(IRF4)hyperactivation restricts murine lupus被引量：2
《Signal Transduction and Targeted Therapy》2023年第6期2475-2477,共3页Shijun He Huihua Ding Li Chen Yiwei Shen Yuting Liu Fenghua Zhu Xiaoqian Yang Nan Shen Zemin Lin Jianping Zuo 
the National Natural Science Foundation of China(Grant Number:81903882,81871240,82001709);the Science and Technology Commission of Shanghai Municipality(Grant Number:22ZR1473700,21S11907700);"Science and Technology Innovation Action Plan"medicine innovation fund by Science and Technology Commission of Shanghai Municipality(Grant Number:21Y31900200).
Dear Editor,Hyperactivation of the type I interferon(IFN)signature has been observed in several systemic autoimmune conditions,and the type I IFN receptor antagonist Saphnelo(anifrolumab-fnia)has been approved in 2021...
关键词：LUPUS INTERFERON ACTIVATION 
Correlation between Hypovitaminosis D Status and Hyperactivation of IL-6/STAT3 Signaling in Clear Cell Renal Cell Carcinoma
《Proceedings of Anticancer Research》2023年第2期6-11,共6页Juan Ji Deqiang Gu Jing-Yang Guo Wei Liang Xue Zhao Lin Li Song Li 
funded by the Health Commission of Hebei Province under the project Chuanxiong Extract Improves Inflammatory Response in Rats with Pyelonephritis Through IL-6/STAT3 Signaling Pathway(Project Number:20231486).
Objective:To analyze serum vitamin D levels in patients with clear cell renal cell carcinoma(ccRCC)by flow cytometry and to investigate the relationship between hypovitaminosis D status and hyperactivation of IL-6/STA...
关键词：Clear cell renal cell carcinoma Vitamin D Interleukin 6 STAT3 HYPERACTIVATION 
Basal Forebrain Cholinergic Innervation Induces Depression-Like Behaviors Through Ventral Subiculum Hyperactivation
《Neuroscience Bulletin》2023年第4期617-630,共14页Nana Yu Huina Song Guangpin Chu Xu Zhan Bo Liu Yangling Mu Jian-Zhi Wang Yisheng Lu 
supported by grants from National Natural Science Foundation of China(82071508,31771190,31730035).
Malfunction of the ventral subiculum(vSub),the main subregion controlling the output connections from the hippocampus,is associated with major depressive disorder(MDD).Although the vSub receives cholinergic innervatio...
关键词：Depression Medial septum SUBICULUM ACETYLCHOLINE Circuit 
Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation被引量：9
《Signal Transduction and Targeted Therapy》2022年第10期3925-3939,共15页Guan-Nan Li Xue-Jiao Zhao Zhen Wang Meng-Shi Luo Shen-Nan Shi Dan-Mei Yan Hua-Yi Li Jia-Hao Liu Yang Yang Jia-Hong Tan Ze-Yu Zhang Ru-Qi Chen Hui-Ling Lai Xiao-Yuan Huang Jian-Feng Zhou Ding Ma Yong Fang Qing-Lei Gao 
funded by the National Science and Technology Major Sub-Project(2018ZX10301402-002);National Natural Science Foundation of China(81772787,82072889,81602291,81874109,82072894);Fundamental Research Funds for the Central Universities(2021yjsCXCY086,2019kfyXMBZ024);the Technical Innovation Special Project of Hubei Province(2018ACA138).
Finely tuned mitogen-activated protein kinase(MAPK)signaling is important for cancer cell survival.Perturbations that push cells out of the MAPK fitness zone result in cell death.Previously,in a screen of the North Ch...
关键词：cancer activation ELEVATED 
Skewed CD39/CD73/adenosine pathway contributes to B-cell hyperactivation and disease progression in patients with chronic hepatitis B被引量：1
《Gastroenterology Report》2021年第1期49-58,I0002,共11页Shuang-Nan Zhou Ning Zhang Hong-Hong Liu Peng Xia Chao Zhang Jin-Wen Song Xing Fan Ming Shi Lei Jin Ji-Yuan Zhang Fu-Sheng Wang 
supported by grants from the Innovative Research Team in the National Natural Science Foundation of China[81721002];the National Science and Technology Major Project[2018ZX10301202].
Background:The mechanisms underlying B-cell hyperactivation in patients with chronic hepatitis B virus(HBV)infection remain largely undefined.The present study assessed the clinical characteristics of the CD39/CD73/ad...
关键词：hepatitis B virus B-LYMPHOCYTE CD39 5’-nucleotidase lymphocyte activation 
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