HYPOMYELINATION

作品数：7被引量：11H指数：2
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Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation
《Science China(Life Sciences)》2023年第8期1858-1868,共11页Shijia Xing Xiaolu Zheng Huifang Yan Yanquan Mo Ruoyu Duan Zhixing Chen Kunhao Wang Kai Gao Tongsheng Chen Shiqun Zhao Jingmin Wang Liangyi Chen 
supported by the National Natural Science Foundation of China(81925022,61827825,32227802,92054301);the Fundamental Research Center Project of the National Natural Science Foundation of China(T2288102);the National Science and Technology Major Project Program(2022YFC3400600);Beijing Natural Science Foundation Key Research Topics(Z20J00059);UMHS-PUHSC Joint Institute for Translational and Clinical Research(BMU2019JI009);Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases(BZ0317);China Postdoctoral Science Foundation(2021M690465)。
Hypomyelination leukodystrophies constitute a group of heritable white matter disorders exhibiting defective myelin development.Initially identified as a lysosomal protein,the TMEM106B D252N mutant has recently been a...
关键词：superresolution imaging OLIGODENDROCYTE TMEM106B LYSOSOME FILOPODIA 
Ablation of Mea6/cTAGE5 in oligodendrocytes significantly impairs white matter structure and lipid content被引量：1
《Life Metabolism》2023年第2期10-22,共13页Tiantian Ma Wei Mao Shaohua Zhang Yaqing Wang Tao Wang Jinghua Liu Lei Shi Xiang Yu Rong Xue Guanghou Shui Zhiheng Xu 
This study was supported in part by grants from the National Natural Science Foundation of China(NSFC)(31921002,31730108,31730039,and 32061143026);Guangdong Province Key Field R&D Program(2018B030335001);Major Projects of the Ministry of Science and Technology(2021ZD0202300,2022ZD0211901,and 2019YFA0707103);the Strategic Priority Research Program and Innovation Program of the Chinese Academy of Sciences(XDB32020100,YJKYYQ20200052,and ZDBS-LY-SM028).
Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons.Abnormal myelin sheath is associated with many neurological diseases.Meningioma-expressed antigen 6(Mea6)/cutaneous T cell ly...
关键词：Mea6 OLIGODENDROCYTE HYPOMYELINATION myelin lipidomic analysis 
Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice被引量：5
《Neuroscience Bulletin》2020年第4期419-426,共8页Xianjun Chen Fei Wang Jingli Gan Zhonghua Zhang Xuejun Liang Tao Li Nanxin Huang Xiaofeng Zhao Feng Mei Lan Xiao 
supported by the National Natural Science Foundation of China (31671117).
Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and my...
关键词：OLIGODENDROCYTE OLIG2 HYPOMYELINATION Cognition Social WITHDRAWAL 
Inhibitory Effect of LPS on the Proliferation of Oligodendrocyte Precursor Cells through the Notch Signaling Pathway inIntrauterine Infection-induced Rats被引量：3
《Current Medical Science》2018年第5期840-846,共7页Yan-qin YING Xue-qin YAN Sheng-juan JIN Yan LIANG Ling HOU Wan-ting NIU Xiao-ping LUO 
This project was supported by grants from Natural Science Foundation of China,Hubei Province (No.2017CFB645)and National Natural Science Foundation of China (No.81471519).
Periventricular white matter injury (PWMI)is very common in survivors of premature birth,and the final outcomes are a reduction in myelinated neurons leading to white matter hypomyelination.How and (or) why the oligod...
关键词：OLIGODENDROCYTE PRECURSOR cells INTRAUTERINE infection HYPOMYELINATION LIPOPOLYSACCHARIDE signaling pathway 
TNP-ATP is Beneficial for Treatment of Neonatal HypoxiaInduced Hypomyelination and Cognitive Decline被引量：2
《Neuroscience Bulletin》2016年第1期99-107,共9页Jie Xiao Yilong Huang Xia Li Longjun Li Ting Yang Lixuan Huang Ling Yang Hong Jiang Hongchun Li Fan Li 
supported by grants from the National Natural Science Foundation of China(81200939 and31260242);National Science and Technology Supporting Plan of China(2014BAI01B00);Natural Science Foundation of Yunnan Province,China(2011FB060);the National Undergraduate Innovation Fund of China(201310678001);the Undergraduate Innovation Fund of Yunnan Province,China(6011202105);Department of Pathology and Pathophysiology, School of Basic Medical Science, Kunming Medical University for his support throughout the study
Our previous study together with other inves- tigations have reported that neonatal hypoxia or ischemia induces long-term cognitive through brain inflammation impairment, at least in part and hypomyelination. How- eve...
关键词：Neonatal hypoxia. Inflammation. IonotropicATP receptors - Glutamate Memory deficit 
Crowdfunding Effort Identifies the Causative Mutation in a Patient with Nystagmus,Microcephaly,Dystonia and Hypomyelination
《Journal of Genetics and Genomics》2015年第2期79-81,共3页Ofer Isakov Dorit Lev Lubov Blumkin Gershon Celniker Esther Leshinsky-Silver Noam Shomron 
supported in part by a fellowship from the Edmond J.Safra Center for Bioinformatics at Tel-Aviv University
Crowdfunding refers to the online gathering of finance via numerous small donations from individual supporters （the ＂crowd＂） in order to fund a service, project or cause from various fields including business, art...
Nitric oxide production is associated to increased lipoperoxidation and active caspase-3 in demyelinated brain regions of the taiep rat
《Advances in Bioscience and Biotechnology》2012年第6期695-704,共10页Guadalupe Soto-Rodríguez Daniel Martínez-Fong Rosa Arroyo Patricia Aguilar-Alonso Hector Rubio José Ramón Eguibar Araceli Ugarte Maricela Torres-Soto Juan Antonio González-Barrios Jorge Cebada Eduardo Brambila Bertha Alicia Leon-Chavez 
We previously showed that the increase in nitric oxide (NO) levels and NO synthase (NOS) expression correlate with the progression of reactive astrocytosis and demyelination in the brains of 6-month-old taiep rats. In...
关键词：HYPOMYELINATION NITRITE MALONYLDIALDEHYDE Apoptosis NECROSIS 
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