N-DEMETHYLATION

作品数：6被引量：5H指数：2
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相关领域：理学医药卫生更多>>
相关作者：黄松林周宏灏伍忠銮欧阳冬生许振华更多>>
相关机构：湖南医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Chemical Research in Chinese Universities》《Systems Microbiology and Biomanufacturing》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金更多>>
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AtPQT11,a P450 enzyme,detoxifies paraquat via N-demethylation被引量：2
《Journal of Genetics and Genomics》2022年第12期1169-1173,共5页Yi-Jie Huang Yue-Ping Huang Jin-Qiu Xia Zhou-Ping Fu Yi-Fan Chen Yi-Peng Huang Aimin Ma Wen-Tao Hou Yu-Xing Chen Xiaoquan Qi Li-Ping Gao Cheng-Bin Xiang 
supported by the National Natural Science Foundation of China(31770273)。
Paraquat(1,1’-dimethyl-4,4’-bipyridinium dichloride,PQ)has been widely used as a broad spectrum nonselective herbicide in agriculture for decades(Baldwin et al.,1968).Plants absorb PQ from their environment and tran...
关键词：thereby converted RESULTANT 
Chiral resolution of N-methyl-d,l-aspartic acid using a predicted N-demethylase from Chloroflexi bacterium 54-19
《Systems Microbiology and Biomanufacturing》2022年第3期507-522,共16页Juanjuan Du Liang Zhang 
supported by the National Key Research and Development Program of China(2018YFA0900300,2021YFC2100300).
N-methyl-d-aspartic acid(NMDA),an amino acid existing in human and animal central nervous system,exerts agonist action on one of the glutamate receptor subtypes and is clinically used for treatment of diabetes,Parkin...
关键词：N-methyl-d-aspartic acid Sarcosine oxidase N-DEMETHYLATION ENANTIOSELECTIVITY Kinetic resolution 
CuCl-catalyzed Oxidative N-Demethylation of Arylamines with tButyl Hydroperoxide被引量：3
《Chemical Research in Chinese Universities》2009年第6期861-865,共5页LIAO Qian XI Chan-juan 
Supported by the National Natural Science Foundation of China(No.20572058)
CuCl-catalyzed oxidative N-demethylation of arylamines proceeded in the presence of tert-butyl hydroperoxide. The one-electron transfer route of oxidative N-demethylation competed favorably with the H-atom abstraction...
关键词：ARYLAMINE Cuprous chloride Catalytic oxidation N-DEMETHYLATION tert-Butyl hydroperoxide 
A Novel Oxidative N-Demethylation of 12-Membered Macrolide with Lead Tetraacetate
《Chinese Chemical Letters》2006年第1期9-11,共3页Wei Ge ZHANG Ying Hua JIN Ping QI Kai BAO Jin Guang LIN Nai Li WANG Xin Shen YAO 
Reaction of 12-membered macrolide 1 with lead tetraacetate in dichloromethane afforded an unexpected, novel oxidative N-demethyl product 3.
关键词：Oxidative N-demethylation 12-membered macrolide lead tetraacetate. 
Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes
《Acta Pharmacologica Sinica》2001年第1期87-92,共6页刘昭前 舒焱 黄松林 王连生 何楠 周宏灏 
China Medical Association 92-568 and 99-697
AIM: The present study was designed to define the kinetic behavior of fluoxetine N-demethylation in human liver microsomes and to identify the isoforms of cy-tochrome P-450 (CYP) involved in this metabolic pathway. ME...
关键词：FLUOXETINE phannacokinetics liver microsomes cytochrome P-450 CYP2C19 cytochrome P-450 CYP2C9 
Clomipramine N-demethylation metabolism in human liver microsomes
《中国药理学报》1998年第5期433-436,共4页伍忠銮 黄松林 欧阳冬生 许振华 谢红光 周宏灏 
目的：研究ＣＹＰ４５０选择性抑制剂对体外氯米帕明（Ｃｌｏ）Ｎ去甲基代谢的影响．方法：应用米氏方程计算肝微粒体中ＣｌｏＮ去甲基代谢的动力学参数，比较加入抑制剂前后这些参数的改变．结果：Ｋｍ１，Ｋｍ２，Ｖｍａｘ１，Ｖ...
关键词：氯米帕明 细胞色素P-450 肝微粒体 去甲基代谢 
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