MEGAKARYOPOIESIS

作品数：6被引量：12H指数：1
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相关机构：中国医学科学院血液病医院(血液学研究所)更多>>
相关期刊：《Signal Transduction and Targeted Therapy》《World Journal of Stem Cells》《Frontiers of Medicine》《Blood Science》更多>>
相关基金：国家自然科学基金更多>>
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Adult megakaryopoiesis:when taking a short-cut results in a different final destination
《Blood Science》2024年第4期60-61,共2页Wenxu Zhu Gavin Tjin Louise E.Purton 
It is now well-established that there are 2 distinct pathways for megakaryopoiesis.One is defined by the traditional stepwise differentiation pathway that progresses from hematopoietic stem and progenitor cells(HSPCs)...
关键词：STEPWISE ERYTHROID sis 
Correction: M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity
《Signal Transduction and Targeted Therapy》2024年第10期4749-4751,共3页Hong-Yan Zhao Yuan-Yuan Zhang Tong Xing Shu-Qian Tang Qi Wen Zhong-Shi Lyu Meng Lv Yu Wang Lan-Ping Xu Xiao-Hui Zhang Yuan Kong Xiao-Jun Huang 
In the process of collating the raw data,the authors noticed three images in Fig.4 were used incorrectly.They made an inadvertent mistake by arranging the figure of M2 Group into M2+LY294002 Group in Fig.4k during the...
关键词：process LY294002 MISTAKE 
Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis
《Frontiers of Medicine》2022年第3期416-428,共13页Jiansong Huang Xin Huang Yang Li Xia Li Jinghan Wang Fenglin Li Xiao Yan Huanping Wang Yungui Wang Xiangjie Lin Jifang Tu Daqiang He Wenle Ye Min Yang Jie Jin 
supported by grants from National Natural Science Foundation of China(Nos.82070118 and 81820108004)and the Zhejiang Provincial Natural Science Foundation of China(Nos.LY 20H080008 and Y 19H080009).
Abivertinib,a third-generation tyrosine kinase inhibitor,is originally designed to target epidermal growth factor receptor(EGFR)-activating mutations.Previous studies have shown that abivertinib has promising antitumo...
关键词：abivertinib Btk inhibitor PLATELET MEGAKARYOCYTE MEGAKARYOPOIESIS thrombopoiesis 
Regulation of megakaryopoiesis by bone marrow macrophage polarization被引量：1
《Blood Science》2021年第4期149-150,共2页Ming Hou 
Immune thrombocytopenia(ITP)is an autoimmune disorder characterized by increased bleeding tendency and thrombocytopenia.The main mechanisms include the loss of immune tolerance,accelerated platelet destruction,impaire...
关键词：IMPAIRED MORTALITY MARROW 
M2 macrophages,but not Ml macrophages,support megakaryopoiesis by upregulating PI3K-AKT pathway activity被引量：10
《Signal Transduction and Targeted Therapy》2021年第7期2196-2209,共14页Hong-Yan Zhao Yuan-Yuan Zhang Tong Xing Shu-Qian Tang Qi Wen Zhong-Shi Lyu Meng Lv Yu Wang Lan-Ping Xu Xiao-Hui Zhang Yuan Kong Xiao-Jun Huang 
This work was supported by the National Key Research and Development Program(2017YFA0104500 and 2019YFC0840606);National Natural Science Foundation of China(82070188,81870139,81930004);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(81621001);the Science and Technology Project of Guangdong Province of China(2016B030230003).
Dysfunctional megakaryopoiesis hampers platelet production,which is closely associated with thrombocytopenia(PT).Macrophages(MΦs)are crucial cellular components in the bone marrow(BM)microenvironment.However,the spec...
关键词：PI3K IMPAIRED supporting 
Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production被引量：1
《World Journal of Stem Cells》2019年第9期666-676,共11页Xiao-Hua Lei Yi-Qing Yang Chi-Yuan Ma En-Kui Duan 
Supported by the National Natural Science Foundation of China Grants,No.31600683 and No.U1738103;Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDA15014000
Platelet transfusion is one of the most reliable strategies to cure patients suffering from thrombocytopenia or platelet dysfunction.With the increasing demand for transfusion,however,there is an undersupply of donors...
关键词：MEGAKARYOPOIESIS PLATELET PRODUCTION TRANSFUSION Bioreactors Stem cells 
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