ERYTHROID

作品数：118被引量：326H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：齐亚德杨晨辉周德权王磊王中更多>>
相关机构：华中科技大学河北医科大学中国医学科学院北京协和医学院北京协和医院更多>>
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相关基金：国家自然科学基金北京市自然科学基金福建省自然科学基金国家教育部博士点基金更多>>
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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation被引量：1
《Neural Regeneration Research》2025年第8期2325-2336,共12页Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li 
supported by the National Natural Science Foundation of China,Nos.82204360(to HM)and 82270411(to GW);National Science and Technology Innovation 2030 Major Program,No.2021ZD0200900(to YL)。
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0...
关键词：antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury 
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2
《Neural Regeneration Research》2025年第6期1776-1788,共13页Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong Li Zhen Wang 
supported by the National Natural Science Foundation of China,Nos.82271327 (to ZW),82072535 (to ZW),81873768 (to ZW),and 82001253 (to TL)。
The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and ce...
关键词：apoptosis CYSTATHIONINE-Β-SYNTHASE nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide MITOCHONDRION NEUROPLASTICITY oxidative stress quinolinic acid reactive oxygen species 
Role of nuclear factor erythroid 2-related factor 2 in negative pressure wound therapy for diabetic foot ulcers
《World Journal of Diabetes》2025年第5期363-373,共11页Hao-Jie Sun Shan-Wen Si Ya-Mei Ma Xue-Kui Liu Hou-Fa Geng Jun Liang 
BACKGROUND Negative pressure wound therapy(NPWT)is a potential treatment for diabetic foot ulcers(DFUs),although the mechanisms underlying its effectiveness remain unclear.This study posits that NPWT may improve wound...
关键词：Negative pressure wound therapy Diabetic foot ulcers Nuclear factor erythroid 2-related factor 2 Kelch-like epichlorohydrin-associated protein 1 HEALING 
Double-edged sword of L-arginine in diabetes:Exploring antiinflammatory and antioxidant strategies
《World Journal of Diabetes》2025年第4期314-317,共4页Shuai Liu Ning Li Jia-Jia Jin Yong-Wei Yu 
The article by Mansouri et al provides a comprehensive investigation into the effects of L-arginine(L-Arg)on diabetic cardiomyopathy.The authors conclude that while a low dose(0.5 g/kg)of L-Arg improves lipid profiles...
关键词：L-ARGININE Diabetic cardiomyopathy Oxidative stress Nuclear factor erythroid 2-related factor 2 Nitric oxide synthase 
Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice
《World Journal of Gastroenterology》2025年第15期96-108,共13页Xin-Yu Wang Fang Liu Qi-Tong Wang Shu-Zhu Li Yu-Zhao Ye Tao Chen Ben-Chi Cai 
Supported by the Hainan Provincial Natural Science Foundation of China,No.823MS133 and No.821QN0979。
BACKGROUND Parkinson's disease(PD)-a progressive neurodegenerative disorder-is characterized by motor and gastrointestinal dysfunction.The exploration of novel therapeutic strategies for PD is vital.AIM To investigate...
关键词：Rhapontin Gastrointestinal dysfunction Parkinson’s disease Nuclear factor erythroid 2-related factor 2 Gut-Brain axis Oxidative stress NEUROINFLAMMATION 
The role of nuclear factor erythroid 2-related factor 2(NRF2)in arsenic toxicity
《Journal of Environmental Sciences》2025年第4期632-644,共13页Sara R.El-Mahrouk Mahmoud A.El-Ghiaty Ayman O.S.El-Kadi 
supported by the Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant[RGPIN 250139]to A.O.S.E.
Arsenic,a naturally occurring toxic element,manifests in various chemical forms and is widespread in the environment.Exposure to arsenic is a well-established risk factor for an elevated incidence of various cancers a...
关键词：ARSENIC NRF2 KEAP1 NQO1 HMOX1 Oxidative stress 
Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway
《Chinese Journal of Integrative Medicine》2025年第2期118-130,共13页LI Zhu-qing ZHANG Feng LI Qi WANG Li SUN Xiao-qiang LI Chao YIN Xue-mei LIU Chun-lei WANG Yan-xin DU Xiao-yu LU Cheng-zhi 
Supported by the National Natural Science Foundation of China(No.82300445);the Natural Science Foundation of Tianjin(No.22JCQNJC01130);the Medical Health Science and Technology Project of Tianjin Municipal Health Commission(No.TJWJ2023QN026)。
Objective:To evaluate the protective effects of gentiopicroside(GPS)against reactive oxygen species(ROS)-induced NOD-like receptor family,pyrin domain containing 3(NLRP3)inflammasome activation in endothelial cells,ai...
关键词：endothelial dysfunction GENTIOPICROSIDE NLRP3 inflammasome SIRT1 nuclear factor erythroid 2-related factor 2 Chinese medicine 
MiR-340-5p affects the proliferation and transfer of gastric cancer cells by targeting lncRNA HCG11 and NRF2 expression
《Oncology and Translational Medicine》2025年第1期29-35,共7页Rina Su Wei Luan Kai Zhang Shuai Liu Xiaoqing Zhang Yanwei Gao 
Funded by the general program of the Nature Fund of InnerMongolia Autonomous Region.
Objective:The aim of the study was to investigate the expression and biological role of nuclear factor erythroid–related factor 2(NRF2)in gastric cancer cells.Methods:Western blotting(WB)and reverse transcription-pol...
关键词：Gastric cancer Nuclear factor erythroid 2 related factor 2(NRF2) Apoptosis COX-2/PEG 2 signaling pathway 
Zhongfeng Xingnao Liquid ameliorates post-stroke cognitive impairment through sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway
《Chinese Journal of Natural Medicines》2025年第1期77-89,共13页Wenqin Yang Wen Wen Hao Chen Haijun Zhang Yun Lu Ping Wang Shijun Xu 
supported by the Science&Technology Department of Sichuan Province(No.2019YFS0040);the Improvement Plan of“Xinglin Scholar”Scientific Research Talent,Chengdu University of Traditional Chinese Medicine(No.XKTD2022002)。
The activation of the sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing ...
关键词：Zhongfeng Xingnao Liquid Post-stroke cognitive impairment Oxidative stress Mitochondrial function Apoptosis Sirtuin1/nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway 
Adult megakaryopoiesis:when taking a short-cut results in a different final destination
《Blood Science》2024年第4期60-61,共2页Wenxu Zhu Gavin Tjin Louise E.Purton 
It is now well-established that there are 2 distinct pathways for megakaryopoiesis.One is defined by the traditional stepwise differentiation pathway that progresses from hematopoietic stem and progenitor cells(HSPCs)...
关键词：STEPWISE ERYTHROID sis 
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