the Stichting ParkinsonFonds,SPF 38000,project number:105475.
Background:Axons,crucial for impulse transmission and cellular trafficking,are thought to be primary targets of neurodegeneration in Parkinson’s disease(PD)and dementia with Lewy bodies(DLB).Axonal degeneration occur...
Ms.Hirschfeld received support from multiple grants during the preparation of this manuscript:T32AG071444 and F31AG074700;Dr.Saykin receives support from multiple NIH grants(P30 AG010133,P30 AG072976,R01 AG019771,R01 AG057739,U19 AG024904,R01 LM013463,R01 AG068193,T32 AG071444,and U01 AG068057 and U01 AG072177);Dr.Risacher receives support from NIH grants AG061788 and K01AG049050.Dr.Nho receives support from NIH grants R01 LM012535 and R03 AG054936.
This literature review investigates the significant overlap between myelin-repair signaling pathways and pathways known to contribute to hallmark pathologies of Alzheimer’s disease(AD).We discuss previously investiga...
Adult-onset autosomal dominant leukodystrophy(ADLD)is a progressive and fatal hereditary demyelination disorder characterized initially by autonomic dysfunction and loss of myelin in the central nervous system(CNS).Ma...