NEUROFILAMENT

作品数：52被引量：93H指数：5
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相关领域：医药卫生更多>>
相关作者：林俊堂杨慈清赵善廷杜蕊杨莹更多>>
相关机构：新乡医学院西北农林科技大学华中科技大学北京师范大学更多>>
相关期刊：《Chinese Medical Journal》《外科研究与新技术（中英文）》《Neuroimmunology and Neuroinflammation》《中华物理医学与康复杂志》更多>>
相关基金：国家自然科学基金国家科技部专项基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis被引量：1
《Neural Regeneration Research》2025年第9期2556-2570,共15页Yongting Lv Hongfu Li 
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited.The principal pathological alterations of the disease include the selective d...
关键词：amyotrophic lateral sclerosis BIOMARKER blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain PROGNOSIS TAR DNA-binding protein 43 
Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases
《Neural Regeneration Research》2025年第8期2373-2381,共9页Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning Cai 
supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL);the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH);the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH);the Sino-German Center for Research Promotion,No.M-0759(to YH);a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。
Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...
关键词：Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein NEURODEGENERATION neurofilament light chain plasma biomarkers single molecule array storage time tau 
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice
《Translational Neurodegeneration》2024年第1期329-350,共22页Nicholas S.Caron Lauren M.Byrne Fanny L.Lemarié Jeffrey N.Bone Amirah E.-E.Aly Seunghyun Ko Christine Anderson Lorenzo L.Casal Austin M.Hill David J.Hawellek Peter McColgan Edward J.Wild Blair R.Leavitt Michael R.Hayden 
Support for N.S.C.and L.M.B.provided by the Huntington’s Disease Society of America Berman/Topper HD Career Development Fellowship.Project operational support for E.J.W.,B.R.L.,and M.R.H.provided by F.Hoffmann-La Roche.Additional operational support for N.S.C.and M.R.H.provided by a Bev Hartig Huntington’s Disease Foundation grant.Funding sources were not involved in the design of experiments,collection and measurement of samples,or analysis and interpretation of the data presented herein.
Background Therapeutic approaches aimed at lowering toxic mutant huntingtin(mHTT)levels in the brain can reverse disease phenotypes in animal models of Huntington’s disease(HD)and are currently being evaluated in cli...
关键词：Neurofilament light chain Response biomarker Huntington’s disease Huntingtin lowering Antisense oligonucleotide Cerebrospinal fluid PLASMA BIOFLUIDS 
Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia
《Translational Neurodegeneration》2023年第1期872-888,共17页Irene Frigerio Max A.Laansma Chen-Pei Lin Emma J.M.Hermans Maud M.A.Bouwman John G.J.M.Bol Yvon Galis-de Graaf Dagmar H.Hepp Annemieke J.M.Rozemuller Frederik Barkhof Wilma D.J.van de Berg Laura E.Jonkman 
funded by The Michael J.Fox Foundation(grant#17253);Stichting ParkinsonFonds(grant#1881);supported by the NIHR biomedical research centre at the University College Hospital of London(UCLH).
Background Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders.In this study,we aimed to investigate the distribution of neurofilaments...
关键词：NEUROFILAMENT NFL Axonal degeneration Parkinson’s disease Parkinson’s disease dementia Dementia with Lewy bodies Cortical thickness Cortical atrophy Mean diffusivity 
Correction:Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia被引量：1
《Translational Neurodegeneration》2023年第1期575-575,共1页Nuole Zhu Miguel Santos-Santos Ignacio Illán-Gala Victor Montal Teresa Estellés Isabel Barroeta Miren Altuna Javier Arranz Laia Muñoz Olivia Belbin Isabel Sala Maria Belén Sánchez-Saudinós Andrea Subirana Laura Videla Jordi Pegueroles Rafael Blesa Jordi Clarimón Maria Carmona-Iragui Juan Fortea Alberto Lleó Daniel Alcolea 
Correction:Translational Neurodegeneration(2021)10:50 https://doi.org/10.1186/s40035-021-00275-w Following publication of this article[1],the below fund-ing information is missing.European Union’s Horizon 2020,’MES-...
关键词：DEGENERATION ACIDIC PLASMA 
Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques被引量：2
《Zoological Research》2023年第1期226-248,共23页Francisco M.Nadal-Nicolás Caridad Galindo-Romero Fernando Lucas-Ruiz Nicholas Marsh-Amstrong Wei Li Manuel Vidal-Sanz Marta Agudo-Barriuso 
supported by the Spanish Ministry of Economy and Competitiveness(PID2019-106498GB-I0);Instituto de Salud Carlos III,Fondo Europeo de Desarrollo Regional“Una manera de hacer Europa”(PI19/00071);Fundación Séneca,Agencia de Ciencia y Tecnología Región de Murcia(19881/GERM/15);Spanish Ministry of Science and Innovation(PID 2019-106498 GB-I00);Intramural Research Program of the National Eye Institute,National Institutes of Health(NIH/NEI RO1 EY029087)。
Univocal identification of retinal ganglion cells(RGCs) is an essential prerequisite for studying their degeneration and neuroprotection. Before the advent of phenotypic markers, RGCs were normally identified using re...
关键词：RGC Optic nerve crush BM88 BRN3A Estrogen-related receptorβ ERRβ NEUN Neurofilament-L PGP9.5 RBPMS γ-SYN βIII-tubulin TUJ1 
TRPV4-induced Neurofilament Injury Contributes to Memory Impairment after High Intensity and Low Frequency Noise Exposures
《Biomedical and Environmental Sciences》2023年第1期50-59,共10页YANG Yang WANG Ju QUAN Yu Lian YANG Chuan Yan CHEN Xue Zhu LEI Xue Jiao TAN Liang FENG Hua LI Fei CHEN Tu Nan 
funded by the Chongqing Postdoctoral Innovative Talent Support Program[Grant No.CQBX2021008];the Chongqing Talents Project[CQYC202105043]。
Objective Exposure to high intensity, low frequency noise(HI-LFN) causes vibroacoustic disease(VAD),with memory deficit as a primary non-auditory symptomatic effect of VAD. However, the underlying mechanism of the mem...
关键词：Low frequency noise Memory impairment TRPV4 NEUROFILAMENT Nerve fibers HippocampusLow frequency noise Memory impairment TRPV4 NEUROFILAMENT Nerve fibers HIPPOCAMPUS 
Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy:Contribution of neurochemical markers to early diagnosis
《Infectious Medicine》2022年第2期140-142,共3页Souheil Zayet Hajer Zahra Nabil Belfeki Timothée Klopfenstein Beate Hagenkötter 
Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late 2019.More recently,there have been sporadic case reports on devel-opment of...
关键词：COVID-19 Miller-fisher syndrome Wernicke encephalopathy Bariatric surgery Phosphorylated neurofilament heavy chain PROTEIN 
Growth associated protein 43 and neurofilament immunolabeling in the transected lumbar spinal cord of lizard indicates limited axonal regeneration被引量：2
《Neural Regeneration Research》2022年第5期1034-1041,共8页Lorenzo Alibardi 
Previous cytological studies on the transected lumbar spinal cord of lizards have shown the presence of differentiating glial cells,few neurons and axons in the bridge region between the proximal and distal stumps of ...
关键词：GAP-43 IMMUNOCYTOCHEMISTRY LIZARD NEUROFILAMENTS regeneration spinal cord 
Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies
《Translational Neurodegeneration》2022年第1期129-147,共19页Yasmine Y.Fathy Laura E.Jonkman John J.Bol Evelien Timmermans Allert J.Jonker Annemieke J.M.Rozemuller Wilma D.J.van de Berg 
the Stichting ParkinsonFonds,SPF 38000,project number:105475.
Background:Axons,crucial for impulse transmission and cellular trafficking,are thought to be primary targets of neurodegeneration in Parkinson’s disease(PD)and dementia with Lewy bodies(DLB).Axonal degeneration occur...
关键词：Α-SYNUCLEIN Insular subregions Axonal length density Alzheimer’s disease pathology NEUROFILAMENT MYELIN 
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