云南高校图书馆联盟文献共享服务平台- IPSCS

IPSCS: 作品数：153被引量：324H指数：9; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：江灿郭军谭小兵戴青原付勇更多>>; 相关机构：暨南大学中南大学广西大学广州医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家科技重大专项广西壮族自治区自然科学基金更多>>

基因工程化iNK^(NKG2A KO)细胞具有HLA-E特异的抗肿瘤活性: 《基础医学与临床》2025年第5期599-607,共9页乔雯华许依董鹏何维陈慧张建民; 国家自然科学基金(32270915,32300745);中国医学科学院医学与健康科技创新工程(2021-I2M-1-035,2021-I2M-1-005);常州西太湖细胞治疗前沿技术发展基金会项目(2024-P-013)。; 目的针对NKG2A-HLA-E负调控通路,构建诱导多能干细胞(iPSC)来源的基因工程NKG2A敲除的NK细胞(NKG2A KO-iNK),在体外初步评价其肿瘤杀伤功能。方法利用基因编辑技术在iPSC中敲除NKG2A,将其在体外诱导分化为NKG2A KO-iNK细胞,并在不同分...; 关键词：诱导多能干细胞(iPSCs) NKG2A 自然杀伤(NK)细胞免疫治疗

利用人诱导多能干细胞开发出新型神经类器官模型或有望评估机体的发育性神经毒性: 《生物医学工程与临床》2025年第2期232-232,共1页; 据Hongen T[Int J Mol Sci,2024,25(23):12523-12523.]报道,日本横滨药科大学等机构研究人员通过研究利用人诱导多潜能干细胞(iPSCs)开发出神经类器官模型,从而使其作为一种新型的体外平台来进行发育性的神经毒性评估。研究人员所开发...; 关键词：神经类器官模型 IPSCS 体外平台发育性神经毒性

考虑分层碳排放的多时间尺度光储充一体站日前运行策略: 《电气技术》2025年第1期1-13,63,共14页彭程徐建勇赵书琪徐建军; 黑龙江省自然科学基金项目(LH2019E016);黑龙江省高校引导性创新基金(15071202301)。; “双碳”背景下,光储充一体站(IPSCS)能有效解决多类型灵活性资源运行独立的问题。为提升源荷协同消纳能力,降低碳排放,本文提出一种考虑分层碳排放和源荷互动的IPSCS多时间尺度日前运行策略。首先,基于历史数据,应用混合预测模型和蒙...; 关键词：光储充一体站(IPSCS) 碳排放多时间尺度改进鲸鱼算法

Subtype‑specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer’s disease: 《Cell Regeneration》2024年第1期150-166,共17页Ran Tao Chunmei Yue Zhijie Guo Wenke Guo Yao Yao Xianfa Yang Zhen Shao Chao Gao Jianqing Ding Lu Shen Shengdi Chen Naihe Jing; National Key Basic Research and Development Program of China(2019YFA0801402,2018YFA0800100,2018YFA0107200,2018YFA0801402);Major Project of Guangzhou National Laboratory(GZNL2023A02005);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020501,XDA16020404);National Natural Science Foundation of China(31800854,32130030,31900454)。; Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by massive neuronal loss in the brain.Both cortical glutamatergic neurons and basal forebrain cholinergic neurons(BFCNs)in the AD brain...; 关键词：Alzheimer’s disease(AD) IPSC Cellular model Basal forebrain cholinergic neuron(BFCN) CORTICAL

Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells被引量：1: 《Bioactive Materials》2024年第6期301-316,共16页Sonia Kiran Yu Xue Drishty B.Sarker Yan Li Qing-Xiang Amy Sang; supported by the National Science Foundation(CBET-1652992 and CBET-1917618 to Y.L.).; Natural killer(NK)cells are cytotoxic immune cells that can eliminate target cells without prior stimulation.Human induced pluripotent stem cells(iPSCs)provide a robust source of NK cells for safe and effective cell-b...; 关键词：Human induced pluripotent stem cells Natural killer cells Atypical teratoid rhabdoid tumor Cytotoxicity Cytokine activation

Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration: 《Neural Regeneration Research》2024年第6期1318-1324,共7页Theodora Mourtzi Nasia Antoniou Christina Dimitriou Panagiotis Gkaravelas Georgia Athanasopoulou Panagiota Nti Kostantzo Olga Stathi Efthymia Theodorou Maria Anesti Rebecca Matsas Fevronia Angelatou Georgia Kouroupi Ilias Kazanis; co-financed by Greece and the European Union(European Social Fund-ESF)through the Operational Programme《Human Resources Development,Education and Lifelong Learning 2014–2020》in the context of the project“NeuroProPar”(MIS 5047138,to IK)。; We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the“weaver”mouse,a model of progressive nigrostriatal degeneration.Here,we extended our...; 关键词：adult neurogenesis BNN-20 brain-derived neurotrophic factor cell replacement induced pluripotent stem cells(iPSCs) neurotrophic factors Parkinson's disease substantia

Induced pluripotent stem cells(iPSCs):molecular mechanisms of induction and applications被引量：3: 《Signal Transduction and Targeted Therapy》2024年第5期2065-2090,共26页Jonas Cerneckis Hongxia Cai Yanhong Shi; supported by the National Institute on Aging of the National Institutes of Health R01 AG072291 and RF1 AG079307;the National Institute of Neurological Disorders and Stroke of the National Institutes of Health U01 NS122101 to Y.S.J.C.is a predoctoral scholar in the Stem Cell Biology and Regenerative Medicine Research Training Program of the California Institute for Regenerative Medicine(CIRM).Figures 1-7 were created with BioRender.com.; The induced pluripotent stem cell(iPSC)technology has transformed in vitro research and holds great promise to advance regenerative medicine.iPSCs have the capacity for an almost unlimited expansion,are amenable to ge...; 关键词：MECHANISMS PROGRAMMING holds

2种饲养层对牛iPSCs从始发态向初始态转化的影响: 《中国兽医学报》2024年第2期335-340,355,共7页陈斓歆姜禹杨蕊朱春玲张博洋王玥琦张言赵彦森唐博张学明; 国家自然科学基金资助项目(32172803,31872434);广东省清远市科技计划资助项目(2018A018)。; 饲养层细胞对获得多能干细胞(pluripotent stem cells,PSCs)非常重要,小鼠胚胎成纤维细胞(mouse embryonic fibroblasts,MEF)已被广泛用作培养和产生多种胚胎干细胞(embryonic stem cells,ESCs)及诱导PSCs(induced PSCs,iPSCs)的饲养层...; 关键词：牛牛胚胎成纤维细胞诱导多能干细胞小鼠胚胎成纤维细胞初始态始发态

Evaluation of the safety and efficiency of cytotoxic T cell therapy sensitized by tumor antigens original from T-ALL-iPSC in vivo: 《Cancer Innovation》2024年第1期50-60,共11页Weiran Li Meiling Zhou Lu Wang Liying Huang Xuemei Chen Xizhuo Sun Tao Liu; Science,Technology and Innovation Commission of Shenzhen Municipality,Grant/Award Number:CYJ20170412155231633;Health Commission of Shenzhen Municipality,Grant/Award Number:SZXK062。; Background:Since RNA sequencing has shown that induced pluripotent stem cells(iPSCs)share a common antigen profile with tumor cells,cancer vaccines that focus on iPSCs have made promising progress in recent years.Prev...; 关键词：adoptive cell therapy drug safety evaluation IPSCS T-ALL

Realizing the potential of exploiting human IPSCs and their derivatives in research of Down syndrome: 《BIOCELL》2023年第12期2567-2578,共12页YAFEI WANG JIELEI NI YUHAN LIU DINGYING LIAO QIANWEN ZHOU XIAOYANG JI GANG NIU YANXIANG NI; supported by Shenzhen Science and Technology Planning Project(Grant No.JCYJ20210324093209024);Stable Support Project of Shenzhen(Grant No.20220812182215001).; Down syndrome(DS)is a genetic condition characterized by intellectual disability,delayed brain development,and early onset Alzheimer’s disease.The use of primary neural cells and tissues is important for understandin...; 关键词：Down syndrome Induced pluripotent stem cell Trisomy 21 NEURODEVELOPMENT Genetic alterations Alzheimer’s disease

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