supported by the grants from the National Natural Science Foundation of China(No.81960223 to C.W.);Applied Basic Research Projects of Yunnan Province(No.202001AY070001-217 to W.J.).
Neonatal hypoxic-ischemic encephalopathy(HIE)is widely acknowledged to cause acute neonatal death and chronic neurological injury[1].Currently,there is no effective treatment for neonatal hypoxia-ischemia brain damage...
Supported by: the National Natural Science Foundation of China, No. 30825039, 30973236, 30770748;Outstanding Young Scientist Foundation of Sichuan Province, China, No. 08ZQ026-069
BACKGROUND: In addition to neuroprotective genes, the targeted genes of hypoxia-inducible factor 1α (HIF-1α) include pro-apoptotic genes. However, the influence of HIF-1α on neuronal apoptosis in hypoxia-ischemi...
This work was supported by the Natural Science Foundation of China (30470598).
Objective To study the developmental changes of glutamic acid decarboxylase-67 ( GAD-67, a GABA synthetic enzyme) in normal and hypoxic ischemic (HI) brain. Methods C57/BL6 mice on postnatal day (P) 5, 9, 21 and...
ThestudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina (No 39670 758)
To evaluate the neuroprotective effect of memantine, a non-competitive antagonist at the N-methyl-D-aspartate receptor, against hypoxic ischemia (HI) by exploring its regulation on the expression and synthesis of heat...