IMMUNOTOXICITY

作品数：20被引量：42H指数：4
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Preclinical testing of immunotoxicity for animal-derived dermal materials
《Medicine in Novel Technology and Devices》2024年第3期128-135,共8页Huan Lian Yu Liu Han Wang Jianxia Xu Qianqian Han 
Animal derived materials have been widely used in biomedical products owing to their good biocompatibility and appropriate mechanical properties.It is crucial to evaluate the immunotoxicity of such materials in precli...
关键词：IMMUNOTOXICITY Preclinical testing Animal-derived materials De-cellularization 
Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms
《Environment & Health》2024年第7期474-485,共12页Nada J.Daood Daniel P.Russo Elena Chung Xuebin Qin Hao Zhu 
National Institute of General Medical Sciences(Grant R01GM148743);National Institute of Child Health and Human Development(Grant UHD113039);National Science Foundation(Grant 2402311);National Institute of Environmental Health Sciences(Grants R01ES031080 and R35ES031709).
Computational modeling has emerged as a time-saving and cost-effective alternative to traditional animal testing for assessing chemicals for their potential hazards.However,few computational modeling studies for immun...
关键词：IMMUNOTOXICITY QSAR Machine learning Aryl hydrocarbon receptor Data mining 
NLRP3 inflammasome activation is involved in manganeseinduced immunotoxicity
《Acta Biochimica et Biophysica Sinica》2022年第2期271-274,共4页Jing Ji Haiyi Yu Lei Liao Jiaojiao Li Kunming Qin Jinyang Shen Bo Guo Xiaofu Shao Jinming Ma Jingquan Dong Song Gao 
supported by the grants from the National Natural Science Foundation of China(No.31470275);the Key Natural Science Research Project of the Jiangsu Higher Education Institutions of China(No.20KJA416002);the Natural Science Foundation of Jiangsu Higher Education Institutions of China(No.20KJB350008);the Science and Technology Project of Lianyungang High-tech Zone of China(No.HZ201901);the Open-end Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening(No.HY202004);the“Blue Project”of Jiangsu Higher Education Institutions of China,and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
Manganese(Mn)is an essential trace element for the normal development of human body.It plays an important role in the regulation of cellular energy level,blood sugar balance,function of immunity,and bone growth,and wo...
关键词：functions MANGANESE ACTIVATION 
Evaluation of the immunomodulatory effects of C_(9-13)-CPs in macrophages被引量：2
《Acta Biochimica et Biophysica Sinica》2021年第9期1154-1165,共12页Zimeng Xue Jianbo Zhu Xia Wang Chunlei Yang Zhengwei Fu 
the grants from the Zhejiang Provincial Natural Science Foundation of China(No.LQ19B070006);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT17R97).
Short-chain chlorinated paraffins(SCCPs)have been listed as a new class of persistent organic pollutants by the Stockholm Convention.SCCPs exhibit carcinogenic-,endocrine-,and metabolism-disrupting effects.However,the...
关键词：SCCPs C_(9-13)-CPs RAW264.7 cells IMMUNOTOXICITY immunomodulatory cytokines 
A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model被引量：6
《Regenerative Biomaterials》2021年第1期52-62,共11页Wen Zou Xing Li Na Li Tianwei Guo Yongfu Cai Xiaoqin Yang Jie Liang Yong Sun Yujiang Fan 
This work was supported by National Key Research and Development Program of China(2018YFC1106800);Sichuan province key research and development project(20ZDYF0191).
Repair and reconstruction of large bone defect were often difficult,and bone substitute materials,including autogenous bone,allogenic bone and artificial bone,were common treatment strategies.The key to elucidate the ...
关键词：autogenous bone alloge nic bone artificial bone bone defect repair OSTEOGENESIS IMMUNOTOXICITY 
Gastrointestinal toxicity induced by microcystins
《World Journal of Clinical Cases》2018年第10期344-354,共11页Jin-Xia Wu Hui Huang Lei Yang Xiao-Feng Zhang Shen-Shen Zhang Hao-Hao Liu Yue-Qin Wang Le Yuan Xue-Min Cheng Dong-Gang Zhuang Hui-Zhen Zhang 
Supported by Henan Natural Science Foundation,No.162300410267;the National Nature Science Foundation of China,Nos.81773384 and 81472948
Microcystins(MCs) are produced by certain bloomforming cyanobacteria that can induce toxicity in various organs, including renal toxicity, reproductive toxicity, cardiotoxicity, and immunosuppressive effects. It has b...
关键词：IMMUNOTOXICITY GASTROINTESTINAL toxicity INTESTINE DEPURATION OXIDATIVE stress MICROCYSTINS 
β-Cypermethrin and its metabolite 3-phenoxybenzoic acid exhibit immunotoxicity in murine macrophages被引量：7
《Acta Biochimica et Biophysica Sinica》2017年第12期1083-1091,共9页
β-Cypermethrin （β-CYP）, one of most important pyrethroids, is widely used to control insects, and has been detected in organisms, including human. Pyrethroids have been shown to pose neurotox- icity, hepatotoxicit...
关键词：β-cypermethrin 3-phenoxybenzoic acid macrophages IMMUNOTOXICITY 
Immunotoxicity assessment of cadinene sesquiterpenes from Eupatorium adenophorum in mice
《Journal of Integrative Agriculture》2016年第10期2319-2325,共7页OUYANG Can-bin LIU Xiao-man YAN Dong-dong LI Yuan WANG Qiu-xia CAO Ao-cheng GUO mei-xia 
supported by the Special Non-profit Agricultural Industrial Research Fund of China (201103027)
Sesquiterpenes in Eupatorium adenophorum are abundant in leaves and have great development potential as biopesticides. The toxicity of sesquiterpenes in immune cells and their corresponding immune functions are not fu...
关键词：histop athology splenocytes 2-deoxo-2-（acetyloxy）-9-oxoageraphorone immunotoxicity Eupato rium adenophorum 
Immunotoxicity of Acrylamide in Female BALB/c Mice被引量：8
《Biomedical and Environmental Sciences》2014年第6期401-409,共9页FANG Jin LIANG Chun Lai JIA Xu Dong LI Ning 
supported by the National Science and Technology Support Program(2012BAK01B00)
Objective To investigate the immunotoxicity of acrylamide （ACR） in female BALB/c mice.Methods A total of 200 female mice weighing 18-22 g were randomly divided into four clusters based on body weight, and each weigh...
关键词：Acrylamide（ACR） IMMUNOTOXICITY Female BALB/c mice 
Long-term exposure to decabrominated diphenyl ether mpairs CD8 T-cell function in adult mice被引量：3
《Cellular & Molecular Immunology》2014年第4期367-376,共10页Weihong Zeng Ying Wang Zhicui Liu Asma Khanniche Qingliang Hu Yan Feng Weiyi Ye Jianglong Yang Shujun Wang Lin Zhou Hao Shen Yan Wang 
ACKNOWLEDGEMENTS We thank Yingxin Yu （Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering,Shanghai University） for determining the BDE-209 concentration, Nining Guo and Qibing Leng （Institute Pasteur of Shanghai, Chinese Academy of Science） for the rLm-OVA infections and Xing Zhang （College of Public Health, Shanghai Jiaotong University School of Medicine） for breeding the animals. This work is supported by the National Basic Research Program of China （2011CB512104）, the 12th Five-Year Plan of National Science and Technology Support （2012BAK17B10） and the National Natural Science Foundation of China （81101252）.
Polybrominated diphenyl ethers （PBDEs） are ubiquitous environmental pollutants that accumulate to high levels in human populations that are subject to occupational or regional industry exposure. PBDEs have been show...
关键词：BDE-209 CD8 T cells continuous exposure IMMUNOTOXICITY T-cell functions 
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