The influence of phlorotannins and bromophenols on the feeding behavior of marine herbivores was determined using bioassay of Turbo cornutus. It was found that phloroglucinol and its oligomers isolated from the brown ...
supported by the State Innovative Drugs Development Program of China (2009ZX09103-661 and 2009ZX09102)
Marine algae contain various bromophenols with a variety of biological activities, including antimicrobial, anticancer, and anti-diabetic effects. Here, we briefly review the recent progress in researches on the bioma...
Supported by the National Major Research Program of China"The Creation for Significant Innovative Drugs"(No.2009ZX09103-148);the Natural Science Foundation of Shandong(No.BS2009YY011);the Natural Science Foundation of Qingdao(No.10-3-4-8-2-JCH);the Program of Qingdao Shinan District(No.2009-HY-2-14)
3-bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-l,2-benzenediol (1) is a natural bromophenol isolated from the red algae Rhodomela confervoides that exhibits significant inhibition against protein tyrosine phosph...
Supported by the National Natural Science Foundation (No. 30530080);the Ministry of Science and Technology of China (Nos. 2007AA09Z402, 2007AA09Z403);the Department of Science and Technology of Shandong Province (No. 2006GG2205023)
Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this specie...
Supported by the National Major Research Program of China (No.2009ZX09103-148);the National High Technology Research and Development Program of China (863 program) (Nos.2007AA09Z410,2007AA091604)
Bromophenols are a set of natural products widely distributed in seaweed, most of which exhibit interesting and useful biological activities. To develop a reliable and efficient synthetic route to these natural bromop...
the National 863 Projects of China (Grant Nos.2007AA09Z410 and 2007AA091604);Key Innovative Project of the Chinese Academy of Sciences (Grant No. KZCX2-YW-209)
Protein tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator in insulin signaling pathways. PTP1B is an effective target for the treatment of type 2 diabetes mellitus. Four bromophenol deriv...
Supported by National "863" Program (No. 2004AA625030, 2001AA620503), Qingdao marine sciences project (No. 04-2-NN-26) and Key Knowledge Innovative Project of the Chinese Academy of Sciences (KZCX3-SW-215).
Four bromophenols were isolated from the extract of marine red alga, Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods including IR, MS, 1D, and 2D-NMR techniques, the...
support from the NNSF(Grant No.99-929-01-26);National“863”Program(Grant No.2001AA620403).
Two new bromophenols were isolated from Rhodomela confervoides. Their structrues were elucidated as 2, 2', 3-tribromo-3', 4, 4', 5-tetrahydroxy-6'-hydroxymethyldiphenylmethane and 2, 2', 3-tribromo-3', 4,4', 5-tetrahy...