the National Natural Science Foundation of China(No.81671101 and No.31471062).
Endothelin-1(ET-1),an endogenous vasoactive peptide,has been found to play an important role in peripheral pain signaling.Acid-sensing ion channels(ASIlCs)are key sensors for extracellular protons and contrbute to pai...
A selective, sensitive and precise assay based on solid phase extraction and liquid chromatography–tandem mass spectrometry(LC–MS/MS) was developed for the simultaneous determination of amiloride(AMI) and hydrochlor...
Dear Editor, Hepatitis C virus (HCV) infection, which causes hepatitis C and can chronically lead to serious and life-threatening dis- eases including liver cirrhosis and hepatocellular carcinoma (Lauer and Walker,...
Aim: Blockade of EGFR by EGFR tyrosine kinase inhibitors such as erlotinib is insufficient for effective treatment of human pancreatic cancer due to independent activation of the Akt pathway, while amiloride, a potas...
Supported by Grants from The Lundbeck Foundation;Aase and Ejnar Danielsens Foundation;Helen and Ejnar Bjoernows Foundation;Region Midjutlands Research Fund
AIM: To quantify changes in urinary excretion of aquaporin2 water channels (u-AQP2), the sodium-potassium-chloride co-transporter (u-NKCC2) and the epithelial sodium channels (u-ENaC) during treatment with bend...
Esophageal adenocarcinoma is increasing in the US and Western countries and frequent gastresophageal reflux or gastresophageal reflux disease carrying gastric acid and bile acid could contribute to esophageal adenocar...
Supported by the National Natural and Science Foundation of China(30871042)
Objective: To observe the effect of different combination antihypertensive therapies on plasma endothelin-1 (ET-1) concentration and left ventricular diastolic function of essential hypertension patients with left ...
Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of met...
supported by the National Natural Science Foundation of China (No. 81200681)
In the retina, pH fluctuations may play an important role in adapting retinal responses to different light intensities and are involved in the fine tuning of visual perception. Acidosis occurs in the subretinal space ...