AMILORIDE

作品数:27被引量:47H指数:4
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相关领域:医药卫生更多>>
相关作者:季勇黄艳张腾跃陈飞虎袁凤来更多>>
相关机构:南京医科大学安徽医科大学中国医学科学院北京协和医学院武汉大学更多>>
相关期刊:《生理学报》《汕头大学医学院学报》《Frontiers in Biology》《Acta Pharmacologica Sinica》更多>>
相关基金:国家自然科学基金上海市科学技术委员会资助项目浙江省自然科学基金江苏省科技厅资助项目更多>>
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Endothelin-1 enhances acid-sensing ion channel currents in rat primary sensory neurons
《Acta Pharmacologica Sinica》2020年第8期1049-1057,共9页Lei Wu Ting-ting Liu Ying Jin Shuang Wei Chun-yu Qiu Wang-ping Hu 
the National Natural Science Foundation of China(No.81671101 and No.31471062).
Endothelin-1(ET-1),an endogenous vasoactive peptide,has been found to play an important role in peripheral pain signaling.Acid-sensing ion channels(ASIlCs)are key sensors for extracellular protons and contrbute to pai...
关键词:ENDOTHELIN-1 acid-sensing ion channels dorsal root ganglion neuron nociceptive response BQ-123 BQ-788 AMILORIDE APETx2 
Simultaneous quantification of amiloride and hydrochlorothiazide in human plasma by liquid chromatography–tandem mass spectrometry被引量:1
《Journal of Pharmaceutical Analysis》2017年第5期288-296,共9页Jaivik V.Shah Priyanka A.Shah Mallika Sanyal Pranav S.Shrivastav 
A selective, sensitive and precise assay based on solid phase extraction and liquid chromatography–tandem mass spectrometry(LC–MS/MS) was developed for the simultaneous determination of amiloride(AMI) and hydrochlor...
关键词:AMILORIDE HYDROCHLOROTHIAZIDE LC–MS/MS SOLID phase extraction Human plasma 
Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride被引量:1
《Protein & Cell》2016年第4期300-304,共5页Linlin Zhao Shuqing Wang Lingyu Du Jyoti Dev Liujuan Zhou Zhijun Liu James J. Chou Bo OuYang 
Dear Editor, Hepatitis C virus (HCV) infection, which causes hepatitis C and can chronically lead to serious and life-threatening dis- eases including liver cirrhosis and hepatocellular carcinoma (Lauer and Walker,...
Amiloride通过抑制缺氧诱导的NHE1表达而延缓calpain介导的ABCA1降解被引量:5
《中国病理生理杂志》2015年第11期1992-1997,共6页莫显刚 张莉 张洛超 王龙 向凝 杨涓 宋翔 
国家自然科学基金资助项目(No.31260250)
目的:研究缺氧对钠氢交换体1(NHE1)表达、细胞内钙离子浓度([Ca2+]i)和钙蛋白酶(calpain)活性的影响,探讨NHE1抑制剂阿米洛利(amiloride)对ABCA1降解的影响以及与calpain相关的机制。方法:RAW264.7细胞缺氧0、12、24和48 h。MTT法检测...
关键词:三磷酸腺苷结合盒转运体A1 阿米洛利 钠氢交换体1 钙蛋白酶 
Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/ AKT signaling pathway被引量:4
《Acta Pharmacologica Sinica》2015年第5期614-626,共13页Yuan-ting ZHENG Hui-ying YANG Tao LI Bei ZHAO Teng-fei SHAO Xiao-qiang XIANG Wei-min CAI 
Aim: Blockade of EGFR by EGFR tyrosine kinase inhibitors such as erlotinib is insufficient for effective treatment of human pancreatic cancer due to independent activation of the Akt pathway, while amiloride, a potas...
关键词:AMILORIDE ERLOTINIB pancreatic cancer drug synergism targeted therapy PI3K/AKT signaling pathway 
Changes in urinary excretion of water and sodium transporters during amiloride and bendroflumethiazide treatment
《World Journal of Nephrology》2015年第3期423-437,共15页Janni M Jensen Frank H Mose Anna-Ewa O Kulik Jesper N Bech Robert A Fenton Erling B Pedersen 
Supported by Grants from The Lundbeck Foundation;Aase and Ejnar Danielsens Foundation;Helen and Ejnar Bjoernows Foundation;Region Midjutlands Research Fund
AIM: To quantify changes in urinary excretion of aquaporin2 water channels (u-AQP2), the sodium-potassium-chloride co-transporter (u-NKCC2) and the epithelial sodium channels (u-ENaC) during treatment with bend...
关键词:AMILORIDE THIAZIDE Sodium-potassium-chloride co-transporter Aquaporin2 Epithelial sodium channels SODIUM WATER Sodium transporters Hypertonic saline URINE 
Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts被引量:1
《Frontiers in Biology》2014年第1期75-81,共7页Baoxiang GUAN Ashraful HOQUE Xiaochun XU 
Esophageal adenocarcinoma is increasing in the US and Western countries and frequent gastresophageal reflux or gastresophageal reflux disease carrying gastric acid and bile acid could contribute to esophageal adenocar...
关键词:esophageal cancer NHE-1 AMILORIDE GUGGULSTERONE cell viability 
Effect of amlodipine combined with telmisartan or compound amiloride on plasma ET-1 concentration and left ventricular diastolic function of essential hypertension patients with left ventricular hypertrophy被引量:2
《Journal of Medical Colleges of PLA(China)》2013年第6期345-354,共10页YIN Yanrong WANG Xin WANG Yaping ZHANG Yong TIAN Gang 
Supported by the National Natural and Science Foundation of China(30871042)
Objective: To observe the effect of different combination antihypertensive therapies on plasma endothelin-1 (ET-1) concentration and left ventricular diastolic function of essential hypertension patients with left ...
关键词:HYPERTENSION Left ventricular hypertrophy ENDOTHELIN-1 Left ventricular diastolic function 
Simple and Rapid Determination of Diuretics by Luminescent Method
《Pharmacology & Pharmacy》2013年第7期520-527,共8页Iuna Tsyrulneva Olga Zaporozhets 
Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of met...
关键词:FUROSEMIDE BUMETANIDE AMILORIDE TRIAMTERENE THIAZIDES Separation Luminescence Human Urine 
Involvement of Acid-sensing Ion Channel 1a in Functions of Cultured Human Retinal Pigment Epithelial Cells被引量:1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2013年第1期137-141,共5页谭健 许益聘 刘广鹏 叶信海 
supported by the National Natural Science Foundation of China (No. 81200681)
In the retina, pH fluctuations may play an important role in adapting retinal responses to different light intensities and are involved in the fine tuning of visual perception. Acidosis occurs in the subretinal space ...
关键词:acid-sensing ion channel la retinal pigment epithelium AMILORIDE PCTxl hydrogen peroxide 
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