O.C.is supported by grants from NIH(DK126070 and DK072517);Cystic Fibrosis Foundation.
A recent study published in Nature by Fan et al.1 identified the structure of human NCC alone and in complex with a thiazide diuretic using cryo-electron microscopy.Despite extensive clinical use of NCC inhibitor thia...
BACKGROUND Hypercalciuria is the most common metabolic risk factor for calcium urolithiasis and is associated with bone loss in adult patients.Reduced bone mineral density(BMD)was already described in idiopathic hyper...
Thiazide-induced hyponatremia is one of the main causes of decreased sodium levels in elderly individuals. This review presents the current evidence regarding the thiazide-associated hyponatremia. Thiazide-associated ...
Drug Induced Pancreatitis is a very common cause of acute pancreatitis in older patients and is often treated by just symptomatic treatment. An old hypertensive lady was admitted repeatedly to emergency department and...
Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of met...