A wide variety of genetic and non-genetic pathologies share serious psychiatric symptoms, which determine a poor quality of life for patients and their families. To evaluate whether bumetanide, a drug initially develo...
the Shanghai Municipal Commission of Health and Family Planning(2018BR33,2017EKHWYX-02,and GWV-10.1-XK07);the Shanghai Shenkang Hospital Development Center(16CR2025B);the Shanghai Clinical Key Subject Construction Project(shslczdzk02902);the National Natural Science Foundation of China(81761128035,81930095,81873909,82001771,and 31860306);the Shanghai Committee of Science and Technology(17XD1403200,20ZR1404900,and 19410713500);Xinhua Hospital of Shanghai Jiao Tong University School of Medicine(2018YJRC03);the National Human Genetic Resources Sharing Service Platform(2005DKA21300);the National Key Research and Development Program of China(2018YFC0910503);111 Project(B18015);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);Guangdong Key Project in‘‘Development of New Tools for Diagnosis and Treatment of Autism”(2018B030335001);the Science and Technology Department of Yunnan Province(202001AV070010)。
With the current limited drug therapy for the core symptoms of autism spectrum disorder(ASD),we herein report a randomized,double-blind,placebo-controlled trial to investigate the efficacy,safety,and potential neural ...
At a time of unprecedented need and despite significant advances in understanding brain function and related diseases,the drug pipeline for treatment of mental ill-health is failing[1,2].The reasons are many,including...
supported by the National Natural Science Foundation of China,No.30160026(to JQS);the High Level Talent Research Project of Shihezi University of China,No.RCSX201705(to YW)
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.We investigated whether the increase of NKCC1 and KCC2 is associa...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Autism Spectrum Disorder is diagnosed early on in a child’s life, anywhere from eighteen to twenty-four months. The disorder is characterized by variab...
Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic...
supported by a grant from Guangzhou Medical University,No.2008C24
Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chlorid...
Generalized edema (anasarca) is common in nephrotic syndrome which rarely produces shortness of breath. Increased shortness of breath associated with rapid weight gain and generalized edema signify congestive heart fa...
Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of met...
Background Little information is available regarding the effect of angiotensin Ⅱ (Ang Ⅱ ) on the bumetanide-sensitive sodium-potassium-2 chloride cotransporter (NKCC2 ), the thiazide-sensitive sodiumchloride cot...