BUMETANIDE

作品数:10被引量:17H指数:2
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相关领域:医药卫生更多>>
相关作者:姜颖魏汉东孙薇贺福初徐辰更多>>
相关机构:北京蛋白质组研究中心天津医科大学更多>>
相关期刊:《Pharmacology & Pharmacy》《Chinese Medical Journal》《Neural Regeneration Research》《Open Journal of Psychiatry》更多>>
相关基金:国家自然科学基金高等学校学科创新引智计划美国中华医学基金会项目更多>>
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Tuberous Sclerosis Complex Associated with Autism Spectrum Features and Bumetanide as a Pharmacological Indication: A Case Report
《Open Journal of Psychiatry》2021年第3期202-213,共12页Maria Cristina Brió Mariana Fazzina Melina Chindi 
A wide variety of genetic and non-genetic pathologies share serious psychiatric symptoms, which determine a poor quality of life for patients and their families. To evaluate whether bumetanide, a drug initially develo...
关键词:BUMETANIDE Tuberous Sclerosis Complex Autism Spectrum Disorder Antagonist NKCC1 
Improved symptoms following bumetanide treatment in children aged 3-6 years with autism spectrum disorder:a randomized,double-blind,placebo-controlled trial被引量:9
《Science Bulletin》2021年第15期1591-1598,M0004,共9页Yuan Dai Lingli Zhang Juehua Yu Xin Zhou Hua He Yiting Ji Kai Wang Xiujuan Du Xin Liu Yun Tang Shining Deng Christelle Langley Wei-Guang Li Jun Zhang Jianfeng Feng Barbara J.Sahakian Qiang Luo Fei Li 
the Shanghai Municipal Commission of Health and Family Planning(2018BR33,2017EKHWYX-02,and GWV-10.1-XK07);the Shanghai Shenkang Hospital Development Center(16CR2025B);the Shanghai Clinical Key Subject Construction Project(shslczdzk02902);the National Natural Science Foundation of China(81761128035,81930095,81873909,82001771,and 31860306);the Shanghai Committee of Science and Technology(17XD1403200,20ZR1404900,and 19410713500);Xinhua Hospital of Shanghai Jiao Tong University School of Medicine(2018YJRC03);the National Human Genetic Resources Sharing Service Platform(2005DKA21300);the National Key Research and Development Program of China(2018YFC0910503);111 Project(B18015);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);Guangdong Key Project in‘‘Development of New Tools for Diagnosis and Treatment of Autism”(2018B030335001);the Science and Technology Department of Yunnan Province(202001AV070010)。
With the current limited drug therapy for the core symptoms of autism spectrum disorder(ASD),we herein report a randomized,double-blind,placebo-controlled trial to investigate the efficacy,safety,and potential neural ...
关键词:Autism spectrum disorder CHILDREN RCT BUMETANIDE GABA 
Placing old wine into new bottles:successful repurposing of bumetanide for treatment of autism spectrum disorder被引量:2
《Science Bulletin》2021年第15期1491-1492,M0003,共3页Anthony G.Phillips 
At a time of unprecedented need and despite significant advances in understanding brain function and related diseases,the drug pipeline for treatment of mental ill-health is failing[1,2].The reasons are many,including...
关键词:自闭症 DRUGS TREATMENT 
Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury被引量:2
《Neural Regeneration Research》2020年第5期912-921,共10页Chao-Yang Tan Yan-Ping Wang Yuan-Yuan Han Bi-Han Lu Wei Ji Li-Cang Zhu Yang Wang Wen-Yan Shi Li-Ya Shan Liang Zhang Ke-Tao Ma Li Li Jun-Qiang Si 
supported by the National Natural Science Foundation of China,No.30160026(to JQS);the High Level Talent Research Project of Shihezi University of China,No.RCSX201705(to YW)
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.We investigated whether the increase of NKCC1 and KCC2 is associa...
关键词:BUMETANIDE chronic constriction injury DORSAL ROOT ganglion DORSAL ROOT reflex hyperalgesia KCC2 nerve regeneration NEUROPATHIC pain NKCC1 primary afferent depolarization WHOLE-CELL patch clamp 
Possible Therapeutic Use of Bumetanide in the Treatment of Autism Spectrum Disorder
《Journal of Biosciences and Medicines》2019年第12期58-67,共10页Sara Kassem Terry Oroszi 
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Autism Spectrum Disorder is diagnosed early on in a child’s life, anywhere from eighteen to twenty-four months. The disorder is characterized by variab...
关键词:AUTISM AUTISM Spectrum DISORDERS BUMETANIDE Chloride Gamma-Aminobutyric Acid Clinical TRIAL 
Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia被引量:1
《Neural Regeneration Research》2016年第5期745-751,共7页Wang-shu Xu Xuan Sun Cheng-guang Song Xiao-peng Mu Wen-ping Ma Xing-hu Zhang Chuan-sheng Zhao 
Bumetanide has been shown to lessen cerebral edema and reduce the infarct area in the acute stage of cerebral ischemia. Few studies focus on the effects of bumetanide on neuroprotection and neurogenesis in the chronic...
关键词:nerve regeneration cerebral ischemia BUMETANIDE Na+-K+-2Cl- cotransporter 1 hippocampal dentate gyrus neurogenesis neuralprecursor cells dendritic development cognitive function neural regeneration 
Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain被引量:2
《Neural Regeneration Research》2014年第10期1055-1062,共8页Yanbing He Shiyuan Xu Junjie Huang Qingjuan Gong 
supported by a grant from Guangzhou Medical University,No.2008C24
Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chlorid...
关键词:nerve regeneration sodium-potassium-chloride co-transporter 1 potassium-chloride co-transporter 2 BUMETANIDE spinal cord dorsal root ganglion incision model postoperative pain neural regeneration 
Effectiveness of Bumetanide Infusion in Treatment of Generalized Edema and Congestive Heart Failure被引量:1
《Open Journal of Internal Medicine》2014年第3期73-81,共9页Anil K. Mandal 
Generalized edema (anasarca) is common in nephrotic syndrome which rarely produces shortness of breath. Increased shortness of breath associated with rapid weight gain and generalized edema signify congestive heart fa...
关键词:BUMETANIDE INFUSION Generalized EDEMA CONGESTIVE HEART Failure 
Simple and Rapid Determination of Diuretics by Luminescent Method
《Pharmacology & Pharmacy》2013年第7期520-527,共8页Iuna Tsyrulneva Olga Zaporozhets 
Diuretics are drugs widely used in treatment of heart failure and hypertension and as doping agents in sports. Wrong prescription and excessive abuse can lead to negative side effects. Despite the effectiveness of met...
关键词:FUROSEMIDE BUMETANIDE AMILORIDE TRIAMTERENE THIAZIDES Separation Luminescence Human Urine 
Altered expression of renal bumetanide-sensitive sodium-pota-ssium-2 chloride cotransporter and Cl- channel -K_2 gene in angiotensin Ⅱ-infused hypertensive rats被引量:1
《Chinese Medical Journal》2005年第23期1945-1951,共7页YE Tao LIU Zhi-quan SUN Chao-feng ZHENG Yong MA Ai-qun FANG Yuan 
ThisstudywassupportedbythegrantfromChinaMedicalBoardofNewYorkInc.(No.01761)
Background Little information is available regarding the effect of angiotensin Ⅱ (Ang Ⅱ ) on the bumetanide-sensitive sodium-potassium-2 chloride cotransporter (NKCC2 ), the thiazide-sensitive sodiumchloride cot...
关键词:angiotensin Ⅱ·bumetanide-sensitive sodium-potassium-2 chloride cotransporter·thiazide-sensitive sodium-chloride cotransporter ·chloride channel 
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