GUGGULSTERONE

作品数：8被引量：7H指数：2
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相关领域：医药卫生更多>>
相关作者：田伟生殷海峰廖清江更多>>
相关机构：中国药科大学中国科学院更多>>
相关期刊：《American Journal of Plant Sciences》《Gastroenterology & Hepatology Research》《Asian Pacific Journal of Tropical Biomedicine》《Frontiers in Biology》更多>>
相关基金：国家自然科学基金更多>>
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Suppressing FXR promotes antiviral effects of bile acids via enhancing the interferon transcription
《Acta Pharmaceutica Sinica B》2024年第8期3513-3527,共15页Xue Liang Kunpeng Liu Xin Jia Cuiqin Cheng Meiqi Zhang Lingdong Kong Qiqi Li Zhe Liu Min Li Junliang Li Yao Wang Anlong Xu 
supported by the National Natural Science Foundation(NNSF)of China(Nos.82371774 and 81901613);Beijing Nova Program(20230484342,China);Natural Science Foundation of Guangdong Province(2020A1515011299,China).
Bile acids(BAs)are natural metabolites in mammals and have the potential to function as drugs against viral infection.However,the limited understanding of chenodeoxycholic acid(CDCA)receptors and downstream signaling,...
关键词：Bile acids FXR IRF3 Interferon transcription RNA virus Z-guggulsterone Broad-spectrum antiviral activity Synergistic inhibitory effect 
Effect of Hirudin on farnesol X receptor pathway during acute intrahepatic cholestasis
《Gastroenterology & Hepatology Research》2022年第2期29-35,共7页Yu-qing Liu Yao Wang Wen-qian Tang Xin Cai Ren-wu Qin Lei Luo Fan Yang 
the 2017 Wuhan Science and Technology Bureau Project(2017060201010222).
Objective:The purpose of this study is to explore the effect of Hirudin on the farnesoid X receptor(FXR)pathway during acute intrahepatic cholestasis in vivo and in vitro.Method:In vivo,sixty male Sprague-Dawley rats ...
关键词：HIRUDIN (Z)-Guggulsterone α-isothiocyanate(ANIT) CHOLESTASIS FXR 
Z-Guggulsterone alleviated renal fibrosis and G_(2)/M cycle arrest through Klotho/P53 signaling
《中国药理学与毒理学杂志》2021年第10期767-768,共2页LIU Min-na LIU Tian-long 
National Natural Science Foundation of China(82003982);Natural Science Foundation of Gansu Province(20JR5RA591;20JR10R015);and Special Cultivation Project of the 940th Hospital(2021yxky026)。
OBJECTIVE Chronic kidney disease(CKD)has become a global public health problem with 10%-15%incidence rate,and inhibiting the renal interstitial fibrosis is considered to be a potential strategy to delay the progressio...
关键词：chronic kidney disease renal interstitial fibrosis Z-Guggulsterone G2/M cycle arrest Klotho/P53 signaling 
Natural compounds as potential inhibitors of SARS-CoV-2 main protease: An insilico study
《Asian Pacific Journal of Tropical Biomedicine》2021年第4期155-163,共9页Amaresh Mishra Yamini Pathak Anuj Kumar Surabhi Kirti Mishra Vishwas Tripathi 
Objective:To explore natural compounds as potential inhibitors against main protease(Mpro)of SARS-CoV-2.Methods:In the current study,systematic molecular docking analysis was conducted using AutoDock 4.2 to determine ...
关键词：SARS-CoV-2 COVID-19 AMENTOFLAVONE GUGGULSTERONE PUERARIN PIPERINE 
Guggulsterone induces apoptosis of human hepatocellular carcinoma cells through intrinsic mitochondrial pathway被引量：3
《World Journal of Gastroenterology》2015年第47期13277-13287,共11页Juan-Juan Shi Xiao-Li Jia Mei Li Ning Yang Ya-Ping Li Xin Zhang Ning Gao Shuang-Suo Dang 
Supported by Science and Technology Foundation of Shaanxi Province;China;No.2007K16-07(9)
AIM: To investigate the effects of guggulsterone on the proliferation and apoptosis of human hepatoma Hep G2 cells in vitro and relevant mechanisms.METHODS: Human hepatocellular carcinoma Hep G2 cells and normal human...
关键词：GUGGULSTERONE HEPATOCELLULAR carcinomacells APOPTOSIS Cell cycle MITOCHONDRIAL PATHWAY 
Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts被引量：1
《Frontiers in Biology》2014年第1期75-81,共7页Baoxiang GUAN Ashraful HOQUE Xiaochun XU 
Esophageal adenocarcinoma is increasing in the US and Western countries and frequent gastresophageal reflux or gastresophageal reflux disease carrying gastric acid and bile acid could contribute to esophageal adenocar...
关键词：esophageal cancer NHE-1 AMILORIDE GUGGULSTERONE cell viability 
<i>Commiphora wightii</i>(Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat被引量：3
《American Journal of Plant Sciences》2013年第6期57-68,共12页Neeraj Jain Rajani S. Nadgauda 
The plants are the primary producers and an indispensible source of food and nutrition, medicine and fuel/biofuel. Unsustainable overharvesting and indiscriminate felling of plants due to ever increasing needs of popu...
关键词：IUCN Conservation COMMIPHORA wightii Somatic Embryogenesis THREATENED 
19-降Guggulsterone的合成
《厦门大学学报（自然科学版）》1999年第S1期101-101,共1页田伟生 殷海峰 廖清江 
关键词：前列腺肥大 甾体皂甙元 资源合理利用 脱羧反应 性甾体 中国科学院 孕甾酮 降血脂 次溴酸 化学研究所 
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