COFACTOR

作品数：48被引量：71H指数：4
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  • 期刊=Synthetic and Systems Biotechnologyx
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Cofactor manipulation to drive biosynthesis of natural products
《Synthetic and Systems Biotechnology》2022年第4期1073-1074,共2页Qidou Gao Mengyao Zhang Xiaobing Yang 
This work was supported by supported by Natural Science Foundation of Shaanxi Province(2020JM-177);Chinese Universities Scientific Fund(2452018314).
Microbial production of value-added products is a promising alternative to plant-and chemical-based routes[1].However,only few of interested chemicals are producing at bulk scale with microbial cell factories(eg.artem...
关键词：enable MANIPULATION INTERESTED 
Improved L -phenylglycine synthesis by introducing an engineered cofactor self-sufficient system
《Synthetic and Systems Biotechnology》2022年第1期513-521,共9页Pengchao Wang Xiwen Zhang Yucheng Tao Xubing Lv Shengjie Cheng Chengwei Liu 
the National Natural Science Foundation of China(Project No.31900064);as well as the Natural Science Foundation of Heilongjiang Province of China(Project No.LH2019C012)。
L-phenylglycine(L-phg)is a valuable non-proteinogenic amino acid used as a precursor to β-lactam antibiotics,antitumor agent taxol and many other pharmaceuticals.L-phg synthesis through microbial bioconversion allows...
关键词：L-phenylglycine Whole-cell biocatalyst Self-sufficient Protein scaffold Hydroxymandelate synthase 
Engineering Escherichia coli to improve tryptophan production via genetic manipulation of precursor and cofactor pathways被引量：10
《Synthetic and Systems Biotechnology》2020年第3期200-205,共6页Zhu Li Dongqin Ding Huiying Wang Linxia Liu Huan Fang Tao Chen Dawei Zhang 
This work was supported by the National Key R&D Program of China(2018YFA0900300);the Tianjin Science Fund for Distinguished Young Scholars(17JCJQJC45300);the Science and Technology Service Network(STS)Initiative of the Chinese Academy of Sciences(CAS)(KFJ-STS-ZDTP-065).
Optimizing the supply of biosynthetic precursors and cofactors is usually an effective metabolic strategy to improve the production of target compounds.Here,the combination of optimizing precursor synthesis and balanc...
关键词：Escherichia coli TRYPTOPHAN Metabolic precursors Cofactor supply 
Modules for in vitro metabolic engineering:Pathway assembly for biobased production of value-added chemicals被引量：5
《Synthetic and Systems Biotechnology》2017年第2期65-74,共10页Hironori Taniguchi Kenji Okano Kohsuke Honda 
Research in our laboratory was supported in part by the Japan Science and Technology Agency(PRESTO,CREST,and A-STEP programs)and the Japan Society for the Promotion of Science(KAKENHI program).
Bio-based chemical production has drawn attention regarding the realization of a sustainable society.In vitro metabolic engineering is one of the methods used for the bio-based production of value-added chemicals.This...
关键词：In vitro metabolic engineering Module GLYCOLYSIS Pentose phosphate pathway Cofactor management 
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