PRODRUGS

作品数：67被引量：100H指数：5
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相关领域：医药卫生化学工程更多>>
相关作者：张礼和谢璐佳郭颖卢俊峰徐靖源更多>>
相关机构：中国医学科学院北京协和医学院北京大学香港城市大学天津医科大学更多>>
相关期刊：《Nano-Micro Letters》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金天津市自然科学基金中国博士后科学基金教育部留学回国人员科研启动基金更多>>
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Unlocking Biomolecular Activity through Pd-Catalyzed Azides Reduction
《Chinese Journal of Chemistry》2024年第19期2305-2315,共11页Fang Fu Wei Xiong Xinyan Xu Yongjie Liu Ming Li Qianqian Qi Xingyu Liu Yuanyuan Zhang Tian Tian Xiang Zhou 
the National Natural Science Foundation of China(Nos.22177089,21721005,92153303,22037004,22177088);the Fundamental Research Funds for the Central Universities(2042021kf0211);Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNJC202309).
Comprehensive Summary Pd-mediated bioorthogonal cleavage reactions have been extensively utilized in the activation of prodrug molecules,precise regulation of protein function,and cellular engineering.However,the avai...
关键词：Decaging strategy PD-CATALYZED Azides reduction Biomolecular activation RNA regulation Biological activity Bioorganic chemistry PRODRUGS 
Practical Synthesis of Valbenazine via 1,3-Dipolar Cycloaddition
《Chinese Journal of Chemistry》2024年第8期841-845,共5页Yalan Peng Zuming Lin Lili Zhu Shiqing Han Sha-Hua Huang Ran Hong 
the National Natural Science Foundation of China(22271194 and 22371295);the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(Grant No.XTD 2210);the Science and Technology Commission of Shanghai Municipality(20XD1404700)is greatly appreciated.
Comprehensive Summary,Valbenazine(Ingrezza),a potent and highly selective inhibitor of vesicular monoamine transporter type 2(VMAT2)through the active metabolite hydrotetrabenazine(HTBZ),has been approved for the trea...
关键词：CYCLOADDITION CHEMOENZYMATIC Kinetic resolution PRODRUGS VMAT2 inhibitor 
From Fluorescent Probes to the Theranostics Platform
《Chinese Journal of Chemistry》2022年第16期1964-1974,共11页Peng Wei Qing Wang Tao Yi 
the financial support from the Fundamental Research Funds for the Central Universities(2232021A-06);the National Natural Science Foundation of China(21877013,22007012,22177019);the Shanghai Sailing Program(20YF1401100).
Since the advent of fluorescent probes,they have been widely used in the field of life sciences.Fluorescent probes can not only light up the cells,tissues and organs,but also be used to explore the bio-distribution of...
关键词：Fluorescent probes Imaging agents PRODRUGS Theranostics platform NANOPARTICLES 
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