POLYPLEX

作品数：16被引量：9H指数：2
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相关领域：医药卫生化学工程更多>>
相关作者：陈顺冯佳张士荣白光吴飞更多>>
相关机构：上海交通大学沈阳药科大学更多>>
相关期刊：《Chinese Journal of Polymer Science》《聚酯工业》《Neural Regeneration Research》《Asian Journal of Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家教育部博士点基金更多>>
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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration被引量：1
《Neural Regeneration Research》2022年第4期854-866,共13页Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong 
supported by the Consejo Nacional de Ciencia Tecnología(Conacyt)de México(Grant#254686,to DMF)。
Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's disease.The human cerebral dopamine...
关键词：axonal growth brain-derived neurotrophic factor gene delivery NANOPARTICLES NEURITOGENESIS neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease REINNERVATION substantia nigra 
Circumvent PEGylation dilemma by implementing matrix metalloproteinase-responsive chemistry for promoted tumor gene therapy被引量：1
《Chinese Chemical Letters》2020年第12期3143-3148,共6页Jingyun Wang Hao Wang Hongyan Cui Peng Sun Xi Yang Qixian Chen 
the National Natural Science Foundation of China(No.21878041);the funding support from Talent Project of Revitalizing Liaoning(No.XLYC1807184);Dalian Science&Technology Innovation Fund(Nos.2020JJ26SN050,2020JJ26GX025)。
Surface modification by poly(ethylene glycol)(PEGylation)has been acknowledged as a powerful strategy in minimizing non-specific reactions for biomedical devices.Once applied into manufacture of drug/gene delivery sys...
关键词：PEGYLATION Tumor Polyplex micelle Gene delivery system Matrix metalloproteinase 
Assembling structurally customizable synthetic carriers of si RNA through thermodynamically self-regulated process
《Asian Journal of Pharmaceutical Sciences》2020年第3期356-364,共9页Guang Bai Tong Xue Xiaotao Dong Uday Kumar Chinta Jia Feng Tuo Jin Fei Wu 
the grant of the Natural Science Foundation of China(Grant nos.81373352 and 81690262)。
This study demonstrates that our previously reported polywraplex, a synthetic siRNA carrier consisting of a uni-molecular polyplex core of customizable size and a self-assembled triblock copolymer envelop, may be cons...
关键词：Networked cationic polymer Thermodynamically self-regulated processes siRNA delivery Unimolecular polyplex Zeta potential regulated polymerization 
核酸载体lipopolyplex的制备及细胞毒性研究
《现代生物医学进展》2015年第27期5204-5207,共4页张士荣 冯佳 陈顺 白光 车俊怡 吴飞 
国家自然科学基金项目(81373352)
目的:为降低聚阳离子基因载体polyplex的正电荷和毒性,在其表面构建中性磷脂膜制备lipopolyplex,并测定lipopolyplex对小鼠结肠癌细胞CT26和人乳腺癌细胞MCF-7的细胞毒性。方法:采用PEI25KDa与DNA复合制备polyplex,在polyplex体系中加...
关键词：POLYPLEX 中性磷脂 Lipopolyplex ZETA电位 细胞毒性 
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