MUCOADHESION

作品数：12被引量：22H指数：2
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相关领域：医药卫生化学工程更多>>
相关作者：黄爱文更多>>
相关机构：中国药科大学更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Journal of Encapsulation and Adsorption Sciences》《Asian Pacific Journal of Tropical Biomedicine》《Chinese Journal of Chemistry》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Double-layer probiotic encapsulation for enhanced bacteriotherapy against inflammatory bowel disease
《Nano Research》2024年第10期9103-9110,共8页Yixin Wang Jun Liu Sichen Yuan Yawen You Quanyin Hu 
supported by the University of Wisconsin Carbone Cancer Center Research Collaborative;the Pancreas Cancer Task Force and the start-up package from the University of Wisconsin-Madison.
Inflammatory bowel disease(IBD)is inflammatory intestinal disorders associated with dysregulated gut microbiota.Bacteriotherapy that leverages bacteria as therapeutics has shown tremendous promise in resolving gut dys...
关键词：PROBIOTICS biomaterial coating inflammatory bowel disease MUCOADHESION oral administration 
Surface Topological Glycosylation-Mediated Mucoadhesion of Bacteria
《Chinese Journal of Chemistry》2024年第13期1447-1455,共9页Xiao Kuang Xiaobing Liu Ju Chen Wenyan Lv Mengmeng Zhang Huan Chen Feng Wu Jinyao Liu 
This work was financially supported by the National Key Research and Development Program of China(2021YFA0909400);the National Natural Science Foundation of China(22105123,22305152);the Shanghai Rising-Star Program(23QA1408600),the Explorer Program of the Science and Technology Commission of Shanghai Municipality(21TS1400400);the Interdisciplinary Program of Shanghai Jiao Tong University(YG2021QN35),the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20210900);the Foundation of National Infrastructures for Translational Medicine(Shanghai)(TMSK-2021-119);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20181704).
Sugar moieties present on bacterial surface serve as pivotal regulators of bacterial activity.Precisely adjusting the abundance and distribution of surface sugar moieties can offer an important approach to manipulatin...
关键词：TOPOCHEMISTRY BACTERIA GLYCOSYLATION SURFACE modification MUCOADHESION CLICK chemistry 
Wet-adhesive materials of oral and maxillofacial region:From design to application被引量：1
《Chinese Chemical Letters》2023年第1期5-18,共14页Yilin Mao Zhengyi Xu Zihan He Jian Wang Zhou Zhu 
supported by the National Natural Science Foundation of China(Nos.82101076,81771122,81970985);Key Research Program of Sichuan Science and Technology Department(No.2019YJ0147);Postdoctoral Research Foundation of China(No.2020M683334)。
Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to tra...
关键词：Oral cavity Oral and maxillofacial region Wet adhesion STOMATOLOGY Adhesive materials MUCOADHESION Tissue engineering 
Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy被引量：3
《Chinese Chemical Letters》2022年第11期4924-4929,共6页Chen Zhang Jiaxin Li Meng Xiao Di Wang Yan Qu Liang Zou Chuan Zheng Jinming Zhang 
supported by the National Natural Science Foundation of China(No.81903811);China Postdoctoral Science Foundation(No.2021M690488);National TCM Multidisciplinary Interdisciplinary Innovation Team Project:Multidisciplinary Evaluation of Southwest Characteristic TCM Resources Multidisciplinary Interdisciplinary Innovation Team(No.ZYYCXTD-D-202209)。
Although multitudinous nanoscale drug-delivery systems(DDSs)have been recommended to improve anti-ulcerative colitis(UC)outcomes,to enhance the mucoadhesion of nanosystems on the colon and specifically release the loa...
关键词：CURCUMIN Enzyme-responsive Micelles MUCOADHESION Ulcerative colitis 
Exploring the potential of functional polymer-lipid hybrid nanoparticles for enhanced oral delivery of paclitaxel被引量：1
《Asian Journal of Pharmaceutical Sciences》2021年第3期387-395,共9页Lu Qin Haiyang Wu Enyu Xu Xin Zhang Jian Guan Ruizhi Zhao Shirui Mao 
This research is financially supported by the Natural Science Foundation of China(Grant No.81273446).
Most biopharmaceutics classification system(BCS)class IV drugs,with poor solubility and inferior permeability,are also substrates of P-glycoprotein(P-gp)and cytochrome P450(CYP450),leading to their low oral bioavailab...
关键词：Polymer-lipid hybrid nanoparticles (PLHNs) Chitosan P-gp inhibitors CYP450 inhibitors MUCOADHESION Oral bioavailability 
Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery被引量：11
《Acta Pharmaceutica Sinica B》2018年第2期147-164,共18页Angela M.Wagner Margaret P.Gran Nicholas A.Peppas 
supported in part by a grant from the National Institutes of Health (R01-EB-00246020);the Cockrell Family Regents Chair. Angela M.Wagner was supported by a National Science Foundation Graduate Research Fellowship (DGE-1610403);the S.E.S.H.A. Endowed Graduate Fellowship in Engineering;the Philanthropic Educational Organization Scholar Award
Therapeutic proteins and peptides have revolutionized treatment for a number of diseases, and the expected increase in macromolecule-based therapies brings a new set of challenges for the pharmaceutics field. Due to t...
关键词：Oral delivery HYDROGELS Protein delivery Peptide delivery Carbohydrates MUCOADHESION 
Topical delivery of acetazolamide by encapsulating in mucoadhesive nanoparticles被引量：1
《Asian Journal of Pharmaceutical Sciences》2017年第6期550-557,共8页Satish Manchanda Pravat Kumar Sahoo 
The intent of this study was to provide topical delivery of acetazolamide by preparing chitosan-STPP (sodium tripolyphosphate) nanoparticles of acetazolamide and evaluate the particle size, zeta potential, drug entrap...
关键词：ACETAZOLAMIDE CHITOSAN STPP OCULAR hypertension MUCOADHESION 
Formulation and Evaluation of Mucoadhesive Microspheres of Pioglitazone Hydrochloride Prepared by Ionotropic External Gelation Technique
《Journal of Encapsulation and Adsorption Sciences》2016年第1期22-34,共13页Nagarajan Sriram Prakash Katakam 
Microspheres containing Pioglitazone hydrochloride were prepared by the ionotropic external gelation method, using sodium alginate with four mucoadhesive polymers namely sodium carboxy methyl cellulose, hydroxy propyl...
关键词：Diabetes Mellitus Mucoadhesive Microspheres Mucoadhesive Polymers MUCOADHESION Sustained Release Ionotropic External Gelation Technique 
Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentally- induced dry eye syndrome被引量：1
《Nano Research》2015年第2期621-635,共15页Shengyan Liu Chu Ning Chang Mohit S. Verma Denise Hileeto Alex Muntz Ulrike Stahl Jill Woods LyndonW. Jones Frank X. Gu 
Topical formulations, commonly applied for treatment of anterior eye diseases, require frequent administration due to rapid clearance from the ocular surface, typically through the lacrimal drainage system or through ...
关键词：BIOCOMPATIBILITY copolymer MUCOADHESION NANOPARTICLE drug delivery OPHTHALMOLOGY 
A clinical perspective on mucoadhesive buccal drug delivery systems被引量：1
《The Journal of Biomedical Research》2014年第2期81-97,共17页Ritu M Gilhotra Mohd Ikram Sunny Srivastava Neeraj Gilhotra 
Mucoadhesion can be defined as a state in which two components, of which one is of biological origin, are held together for extended periods of time by the help of interfacial forces. Among the various transmucosal ro...
关键词：buccal mucosa clinical perspective MUCOADHESION patents transmucosal route 
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