AXONOPATHY

作品数：5被引量：5H指数：1
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相关领域：医药卫生更多>>
相关作者：孙燕官阳戴甲培何敬罗艺更多>>
相关机构：华中科技大学阿姆斯特丹大学中南民族大学更多>>
相关期刊：《Neural Regeneration Research》《Neuroscience Bulletin》《Neuroscience & Medicine》更多>>
相关基金：国家自然科学基金更多>>
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Axonopathy Underlying Amyotrophic Lateral Sclerosis:Unraveling Complex Pathways and Therapeutic Insights
《Neuroscience Bulletin》2024年第11期1789-1810,共22页Tongshu Luan Qing Li Zhi Huang Yu Feng Duo Xu Yujie Zhou Yiqing Hu Tong Wang 
supported by the National Natural Science Foundation of China(32271001 and 31871036).
Amyotrophic Lateral Sclerosis(ALS)is a complex neurodegenerative disorder characterized by progressive axonopathy,jointly leading to the dying back of the motor neuron,disrupting both nerve signaling and motor control...
关键词：Amyotrophic lateral sclerosis Axonopathy Axon trafficking Protein aggregation Mitochondrial defect Neurotrophicfactor 
Axonal regeneration and sprouting as a potential therapeutic target for nervous system disorders被引量：3
《Neural Regeneration Research》2021年第10期1901-1910,共10页Katherine L.Marshall Mohamed H.Farah 
This work was supported by the Muscular Dystrophy Association,No.W81XWH1910229(to MHF);from Department of Defense’s Congressionally Directed Medical Research Program,and Maryland Stem Cell Research Fund,No.2019-MSCRFD-5093(to MHF).
Nervous system disorders are prevalent health issues that will only continue to increase in frequency as the population ages.Dying-back axonopathy is a hallmark of many neurologic diseases and leads to axonal disconne...
关键词：amyotrophic lateral sclerosis axonal regeneration dying-back axonopathy in vitro neuromuscular junction iPSC-derived motor neurons microfluidic device motor axon sprouting 
Axon injury induced endoplasmic reticulum stress and neurodegeneration被引量：1
《Neural Regeneration Research》2016年第10期1557-1559,共3页Yang Hu 
supported by grants from National Eye Institute(R01EY023295,R01EY024932);BrightF ocus Foundation(G2013046);National Multiple Sclerosis Society(RG 5021A1)to YH
Injury to central nervous system axons is a common early characteristic of neurodegenerative diseases. Depending on its location and the type of neuron, axon injury often leads to axon degeneration, retrograde neurona...
关键词：endoplasmic reticulum stress AXONOPATHY retinal ganglion cell optic nerve NEURODEGENERATION CHOP XBP-1 
Early Exposure to Environmental Toxin Contributes to Neuronal Vulnerability and Axonal Pathology in a Model of Familial ALS
《Neuroscience & Medicine》2012年第4期404-417,共14页Grace Lee Christopher A. Shaw 
Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons. Sporadic ALS causality is not well ...
关键词：SOD1 ALS NEUROTOXIN AXONOPATHY NMJ GLIOSIS Toxicity 
The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer’s disease被引量：1
《Neuroscience Bulletin》2011年第5期287-299,共13页肖爱武 何敬 王茜 罗艺 孙燕 周艳平 官阳 Paul J.Lucassen 戴甲培 
supported by an"Excellent Project"of the China Ministry of Human Resources for Return Overseas Chinese Scholarship;partly by the Research Foundation for"Key Laboratory of Neu-roscience and Neuroengineering"of South-Central University for Nationalities(No.XJS09001);the National Natural Science Foundation of China(No.31070961)
Objective The production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in Alzheimer’s disease （AD）. However,...
关键词：Alzheimer’s disease AXONOPATHY senile plaques neurofibrillary tangles postmortem tracing 
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