NEUROTOXIN

作品数:44被引量:59H指数:4
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相关领域:医药卫生生物学更多>>
相关作者:喻志强潘建义林一群常珊更多>>
相关机构:长崎大学浙江理工大学华南农业大学乐山师范学院更多>>
相关期刊:《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Science China Chemistry》《World Journal of Gastroenterology》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划浙江省教育厅科研计划天津市自然科学基金更多>>
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Investigation on cyanobacterial production of the proposed neurotoxinβ-N-methylamino-L-alanine(BMAA)
《Water Biology and Security》2023年第4期128-135,共8页Zi-Qian Wang Suqin Wang Ju-Yuan Zhang Gui-Ming Lin Nanqin Gan Lirong Song Xiaoli Zeng Cheng-Cai Zhang 
supported by the Featured Institute Service Project from the Institute of Hydrobiology,the Chinese Academy of Sciences(Grant No.:Y85Z061601).
β-N-methylamino-L-alanine(BMAA)is an environmental neurotoxin thought to be produced by cyanobacteria.However,the cyanobacterial origin of BMAA remains controversial.The detection method and culture conditions of cya...
关键词:Neurodegenerative disease CYANOBACTERIA BMAA detection Algal bloom 
Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer’s disease by neurotoxin neutralization and immune recognition suppression被引量:1
《Bioactive Materials》2023年第8期337-352,共16页Meng Cheng Caihua Ye Chunxiao Tian Dongju Zhao Haonan Li Zuhao Sun Yuyang Miao Qiang Zhang Junping Wang Yan Dou 
financially supported by the National Natural Science Foundation of China(Grant No.81871431,82171905 and 81801828);the Tianjin Natural Science Foundation(Grant No.21JCQNJC01570 and 22JCYBJC01340);Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-001A);Tianjin Municipal Education Research Project(20140115);Fund for Distinguished Young Scholars of Tianjin Medical University General Hospital(22ZYYJQ03).
Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain,leading to neurodegeneration in Alzheimer’s disease(AD).Blocking active recognition of microglia w...
关键词:Alzheimer’s disease Biomimetic nanomedicine Biological neutralization Immune recognition and response Neuroinflammation-targeted therapy 9.4T MR imaging 
Involvement of CYP347W1 in neurotoxin 3-nitropropionic acid-based chemical defense in mustard leaf beetle Phaedon cochleariae被引量:1
《Insect Science》2022年第2期453-466,共14页Nanxia Fu Tobias Becker Wolfgang Brandt Maritta Kunert Antje Burse Wilhelm Boland 
supported by the Max Planck Society and the China Scholarship Council(grant number 201406300098).
Chrysomelina beetlesstore 3-nitropropionic acid in form of a pretoxin,isoxazolin-5-one glucoside-conjugated ester,to protect themselves against predators.Here we identified a cytochrome P450 monooxygenase,CYP347W1,to ...
关键词:chemical defense isoxazolin-5-one glucoside isoxazolin-5-one glucoside ester leaf beetles P450 3-nitropropionic acid(3-NPA) 
Successful treatment of encrusted cystitis:A case report and review of literature被引量:1
《World Journal of Clinical Cases》2020年第18期4234-4244,共11页Jin-Gao Fu Ke-Ji Xie 
BACKGROUND Encrusted cystitis(EC)is a chronic inflammation of the bladder associated with mucosal encrustations.Early diagnosis and optimal treatment are not well established.Here,we report a case of EC successfully t...
关键词:CYSTITIS Encrusted cystitis Incrusted cystitis Hyaluronic acid Case report Botulinum-A neurotoxin Botulinum toxin 
S-methyl-L-cysteine Protects against Antimycin A-induced Mitochondrial Dysfunction in Neural Cells via Mimicking Endogenous Methionine-centered Redox Cycle被引量:1
《Current Medical Science》2020年第3期422-433,共12页Lan NI Xin-lei GUAN Fu-feng CHEN Peng-fei WU 
This work was supported by grants from the National Natural Science Foundation of China(No.81773712,No.81473198);the Foundation for Innovative Research Groups of NSFC(No.81721005);the National Basic Research Program of China(973 Program,No.2014CB744601);Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(No.2015CFA020);PCSIRT(No.IRT13016).
Mitochondrial superoxide overproduction is believed to be responsible for the neurotoxicity associated with neurodegeneration.Mitochondria-targeted antioxidants,such as MitoQ,have emerged as potentially effective anti...
关键词:methionine sulfoxide reductase A Met oxidase S-methyl-L-cysteine NEUROTOXIN 1-METHYL-4-PHENYLPYRIDINIUM 
The beneift of combined radiofrequency and ultrasound to enhance surgical and nonsurgical outcomes for the face and neck
《Plastic and Aesthetic Research》2020年第2期64-70,共7页Christine A.Catinis Suneel Chilukuri 
As people live longer and stay healthier,many want to look as youthful as they feel.The general population continues to explore nonsurgical options to augment and possibly delay traditional rhytidectomy.Herein,we pres...
关键词:FACELIFT neck lift NONSURGICAL RADIOFREQUENCY ULTRASOUND fillers BOTOX NEUROTOXIN 
μ-TRTX-Ca1a: a novel neurotoxin from Cyriopagopus albostriatus with analgesic effects被引量:2
《Acta Pharmacologica Sinica》2019年第7期859-866,共8页Yun-xiao Zhang De-zheng Peng Qing-feng Zhang Biao Huang Qiu-chu Yang Dong-fang Tang Min-zhi Chen Ming-qiang Rong Zhong-hua Liu 
National Natural Science Foundation of China (81573320 and 31670783).
Human genetic and pharmacological studies have demonstrated that voltage-gated sodium channels (VGSCs) are promising therapeutic targets for the treatment of pain. Spider venom contains many toxins that modulate the a...
关键词:μ-TRTX-Ca1a TARANTULA SPIDER PEPTIDE hNav1.7 ELECTROPHYSIOLOGY ANALGESIC activity 
Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain被引量:12
《Neuroscience Bulletin》2019年第4期661-672,共12页Yang Li Jing Liu Xu Liu Cun-Jin Su Qi-Lin Zhang Zhi-Hong Wang Lei-Fang Cao Xue-Yan Guo Ya Huang Weifeng Luo Tong Liu 
supported by grants from the National Natural Science Foundation of China (81870874, 31371179, 81300968, and 81671270);the Natural Science Foundation of Jiangsu Province, China (BK20170004, 2015-JY-029, and BK20140372);Jiangsu Key Laboratory of Neuropsychiatric Diseases (BM2013003);the Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project Funding (XKQ2015002);the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (KYCX17-2000);Suzhou Science and Technology For People’s Livelihood (SYS201706);the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (KYCX17_2034)
The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A(BoNT/A)on depression-like behaviors in mice and to explore the potential mechanisms.These results revealed that a single faci...
关键词:BOTULINUM NEUROTOXIN Depression 5-HT BDNF HIPPOCAMPUS 
Latest Advances in the Treatment of Post-stroke Limb Spasm with Botulinum Neurotoxin
《Journal of Advances in Medicine Science》2018年第4期133-139,共7页Shuhua Chen Lingjing Jin 
Objective: To describe the latest progress in the use of botulinum neurotoxin for post-stroke limb spasm. Methods: This paper looks up the relevant research literatures in recent years in PubMed, Web of Science, Sprin...
关键词:BOTULINUM NEUROTOXIN POST-STROKE LIMB SPASM GUIDING technology Combination therapy Efficacy evaluation 
Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis induced by rotenone and 6-hydroxydopamine
《Neural Regeneration Research》2018年第11期1981-1987,共7页Su Peng Li Xu Jin-Yu Ma Xiao-Song Gu Cheng Sun 
supported by the National Natural Science Foundation of China,No.81471037,81770841;a grant from the Basic Research of Jiangsu Education Department of China,No.14KJA180006;a grant from the Six Talent Summit Project of Jiangsu Province of China,No.SWYY-051;a grant from the Priority Academic Program Development of Jiangsu Higher Education Institutions of China
It has been well documented that Achyranthes bidentata polypeptides(ABPPs) are potent neuroprotective agents in several types of neurons. However, whether ABPPs protect dopaminergic neurons from apoptosis induced by...
关键词:nerve regeneration Achyranthes bidentata polypeptides neuroprotection cell apoptosis NEUROTOXIN mitochondrial dysfunction cell viability Bcl-2/Bax neural regeneration 
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