supported by the Featured Institute Service Project from the Institute of Hydrobiology,the Chinese Academy of Sciences(Grant No.:Y85Z061601).
β-N-methylamino-L-alanine(BMAA)is an environmental neurotoxin thought to be produced by cyanobacteria.However,the cyanobacterial origin of BMAA remains controversial.The detection method and culture conditions of cya...
financially supported by the National Natural Science Foundation of China(Grant No.81871431,82171905 and 81801828);the Tianjin Natural Science Foundation(Grant No.21JCQNJC01570 and 22JCYBJC01340);Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-001A);Tianjin Municipal Education Research Project(20140115);Fund for Distinguished Young Scholars of Tianjin Medical University General Hospital(22ZYYJQ03).
Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain,leading to neurodegeneration in Alzheimer’s disease(AD).Blocking active recognition of microglia w...
supported by the Max Planck Society and the China Scholarship Council(grant number 201406300098).
Chrysomelina beetlesstore 3-nitropropionic acid in form of a pretoxin,isoxazolin-5-one glucoside-conjugated ester,to protect themselves against predators.Here we identified a cytochrome P450 monooxygenase,CYP347W1,to ...
BACKGROUND Encrusted cystitis(EC)is a chronic inflammation of the bladder associated with mucosal encrustations.Early diagnosis and optimal treatment are not well established.Here,we report a case of EC successfully t...
This work was supported by grants from the National Natural Science Foundation of China(No.81773712,No.81473198);the Foundation for Innovative Research Groups of NSFC(No.81721005);the National Basic Research Program of China(973 Program,No.2014CB744601);Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(No.2015CFA020);PCSIRT(No.IRT13016).
Mitochondrial superoxide overproduction is believed to be responsible for the neurotoxicity associated with neurodegeneration.Mitochondria-targeted antioxidants,such as MitoQ,have emerged as potentially effective anti...
As people live longer and stay healthier,many want to look as youthful as they feel.The general population continues to explore nonsurgical options to augment and possibly delay traditional rhytidectomy.Herein,we pres...
National Natural Science Foundation of China (81573320 and 31670783).
Human genetic and pharmacological studies have demonstrated that voltage-gated sodium channels (VGSCs) are promising therapeutic targets for the treatment of pain. Spider venom contains many toxins that modulate the a...
supported by grants from the National Natural Science Foundation of China (81870874, 31371179, 81300968, and 81671270);the Natural Science Foundation of Jiangsu Province, China (BK20170004, 2015-JY-029, and BK20140372);Jiangsu Key Laboratory of Neuropsychiatric Diseases (BM2013003);the Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project Funding (XKQ2015002);the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (KYCX17-2000);Suzhou Science and Technology For People’s Livelihood (SYS201706);the Postgraduate Research and Practice Innovation Program of Jiangsu Province, China (KYCX17_2034)
The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A(BoNT/A)on depression-like behaviors in mice and to explore the potential mechanisms.These results revealed that a single faci...
Objective: To describe the latest progress in the use of botulinum neurotoxin for post-stroke limb spasm. Methods: This paper looks up the relevant research literatures in recent years in PubMed, Web of Science, Sprin...
supported by the National Natural Science Foundation of China,No.81471037,81770841;a grant from the Basic Research of Jiangsu Education Department of China,No.14KJA180006;a grant from the Six Talent Summit Project of Jiangsu Province of China,No.SWYY-051;a grant from the Priority Academic Program Development of Jiangsu Higher Education Institutions of China
It has been well documented that Achyranthes bidentata polypeptides(ABPPs) are potent neuroprotective agents in several types of neurons. However, whether ABPPs protect dopaminergic neurons from apoptosis induced by...