1-METHYL-4-PHENYLPYRIDINIUM

作品数：23被引量：55H指数：4
导出分析报告
相关领域：医药卫生更多>>
相关作者：孙圣刚田有勇陈小武称道宾王勇更多>>
相关机构：华中科技大学镇江市第一人民医院郧阳医学院附属东风医院首都医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Journal of Traditional Chinese Medical Sciences》《World Journal of Traditional Chinese Medicine》《Journal of Hainan Medical University》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划湖北省自然科学基金镇江市科技支撑计划(社会发展)项目更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils被引量：1
《Neural Regeneration Research》2024年第6期1375-1384,共10页Tong Shen Guiyun Cui Hao Chen Long Huang Wei Song Jie Zu Wei Zhang Chuanying Xu Liguo Dong Yongmei Zhang 
supported by the National Natural Science Foundation of China,Nos.82271257(to YZ)and 82071228(to YZ);Qing Lan Project(to YZ);Open Competition Grant of Xuzhou Medical University(to YZ);Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX21_2705(to TS)。
Microglia-mediated neuroinflammation is considered a pathological feature of Parkinson's disease.Triggering receptor expressed on myeloid cell-1(TREM-1)can amplify the inherent immune response,and crucially,regulate i...
关键词：1-methyl-4-phenylpyridiniumion dopaminergic neurons infiltration 1-methyl-4-phenyl-1 2 3 6-TETRAHYDROPYRIDINE MICROGLIA NEUTROPHILS neuroinflammation Parkinson's disease SYK TREM-1 
The transient receptor potential melastatin 2:a new therapeutical target for Parkinson's disease?被引量：4
《Neural Regeneration Research》2023年第8期1652-1656,共5页Ana Flávia F.Ferreira Luiz Roberto G.Britto 
funded by Coordination for the Improvement of Higher Education Personnel (CAPES,Brazil-Finance Code 001,to LRB);the S?o Paulo Research Foundation(FAPESP,Brazil,project#2018/07366-4);The National Council for Scientific and Technological Development (CNPq,Brazil,project#303006/2018-8,to LRB);a PhD fellowship from FAPESP under Grant Agreement No 2020/02109-3。
The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating m...
关键词：1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine(MPTP) 1-methyl-4-phenylpyridinium(MPP+) 6-HYDROXYDOPAMINE AG490 CLOTRIMAZOLE flufenamic acid N-(p-amylcinnamoyl)anthranilic acid Parkinson's disease poly-ADPR polymerase type 1(PARP1) ROTENONE PARAQUAT transient receptor potential melastatin 2(TRPM2) 
Mechanism of mitochondrial protection by the Buyin Qianzheng formula in a Parkin overexpression cell model
《Journal of Traditional Chinese Medical Sciences》2022年第1期59-68,共10页Cuicui Cheng Yushan Gao Cong Gai Wandi Feng Haojie Ma Jing Feng Zhenyu Guo Shujing Zhang Jie Wu Hongmei Sun 
This work is supported by the National Natural Science Foundation of China(81774110 and 81573773).
Objective:To identify the molecular mechanisms of the effects of the Buyin Qianzheng formula(BYQZF)on the mitochondrial dynamics in a Parkin overexpression Parkinson's disease(PD)cell model.Methods:First,a stable Park...
关键词：Parkinson's disease Parkin overexpression Mitochondria Buyin Qianzheng formula Neurotoxin 1-methyl-4-phenylpyridinium ion SH-SY5Y Mitofusin 2 Dynamic-related protein 1 
Korean red ginseng decreases 1-methyl-4-phenylpyridinium-induced mitophagy in SH-SY5Y cells被引量：4
《Journal of Integrative Medicine》2021年第6期537-544,共8页Hyongjun Jeon Hee-Young Kim Chang-Hwan Bae Yukyung Lee Sungtae Koo Seungtae Kim 
financially supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korea government(MSIT)(No.NRF-2019R1A2C1085130)。
Objective:Mitophagy is known to contribute towards progression of Parkinson’s disease.Korean red ginseng(KRG)is a widely used medicinal herb in East Asia,and recent studies have reported that KRG prevents 1-methyl-4-...
关键词：Parkinson’s disease APOPTOSIS MITOPHAGY 1-METHYL-4-PHENYLPYRIDINIUM Korean red ginseng 
Neuroprotective Effects of San-Jia-Fu-Mai Decoction: Studies on the in vitro and in vivo Models of Parkinson's Disease被引量：2
《World Journal of Traditional Chinese Medicine》2021年第2期192-200,共9页Chang Qu Ling Liu Qing-Qing Xu Yan-Fang Xian Zhi-Xiu Lin 
supported by the Innovation and Technology Commission Funding Administrative System of Hong Kong(Project No.:ITS/122/19FP);the Natural Science Fund of Guangdong(project no.2019A1515011257)
Objective:The objective of this study was to investigate whether 70%aqueous ethanol extract of San-Jia-Fu-Mai decoction extract(SJFMDE)could protect against 1-methyl-4-phenylpyridinium(MPP+)-induced oxidative stress i...
关键词：1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine 1-METHYL-4-PHENYLPYRIDINIUM motor function deficits oxidative stress Parkinson’s disease San-Jia-Fu-Mai decoction 
Protective effect of Fructus Mume total flavone against SH-SY5Y cells damage induced by MPP+and its mechanism
《Journal of Hainan Medical University》2021年第7期11-15,共5页Chun-Ling Wang Xiao-Dong Wen Ning Luo Yuan-Jing Jiang Ying Jiang Zhen Zeng 
National Natural Science Foundation of China Project(No.82060888);Approved Project of Guangxi Health Department(No.Z2016220);Approved Project of Guangxi Administration of Traditional Chinese Medicine(No.GZZC2020107)。
Objective:To investigate the neuroprotective effects of Fructus Mume total flavone(FMF)against cell apoptosis and mitochondrial injury induced by 1-methyl-4-phenylpyridinium(MPP^(+))in human neuroblastoma(SH-SY5Y)cell...
关键词：Parkinson’s disease Fructus Mume total flavone 1-METHYL-4-PHENYLPYRIDINIUM SH-SY5Y cell Cell apoptosis 
S-methyl-L-cysteine Protects against Antimycin A-induced Mitochondrial Dysfunction in Neural Cells via Mimicking Endogenous Methionine-centered Redox Cycle被引量：1
《Current Medical Science》2020年第3期422-433,共12页Lan NI Xin-lei GUAN Fu-feng CHEN Peng-fei WU 
This work was supported by grants from the National Natural Science Foundation of China(No.81773712,No.81473198);the Foundation for Innovative Research Groups of NSFC(No.81721005);the National Basic Research Program of China(973 Program,No.2014CB744601);Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(No.2015CFA020);PCSIRT(No.IRT13016).
Mitochondrial superoxide overproduction is believed to be responsible for the neurotoxicity associated with neurodegeneration.Mitochondria-targeted antioxidants,such as MitoQ,have emerged as potentially effective anti...
关键词：methionine sulfoxide reductase A Met oxidase S-methyl-L-cysteine NEUROTOXIN 1-METHYL-4-PHENYLPYRIDINIUM 
Intracerebroventricularly-administered 1-methyl-4-phenylpyridinium ion and brain-derived neurotrophic factor affect catecholaminergic nerve terminals and neurogenesis in the hippocampus,striatum and substantia nigra
《Neural Regeneration Research》2018年第4期717-726,共10页Jun-Fang Chen Man Wang Ying-Han Zhuang Thomas Behnisch 
supported by the National Natural Science Foundation of China,No.31320103906(to TB)
Parkinson＇s disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra.A highly similar pattern of neurodegeneration can be induced by 1-methyl-4-p...
关键词：nerve regeneration Parkinson＇s disease MPTP brain-derived neurotrophic factor intracerebroventricular infusion dopaminergic fibers NOREPINEPHRINE tyrosine hydroxylase HIPPOCAMPUS substantia nigra STRIATUM NEUROGENESIS neural regeneration 
The basic helix-loop-helix(bHLH)transcription factor,DEC1,provides neuroprotection from apoptosis induced by MPP^+ through PI3K/Akt pathway in SHSY5Y cells
《中国药理学与毒理学杂志》2016年第10期1027-1027,共1页ZHU Zhu WANG Yu-wen YANG Jian 
The project supported by National Natural Science Foundation of China(81573503,81373443);by the Major Project of Jiangsu Provincial Department of Education(13KJA310003)
OBJECTIVE To determine the role of the basic helix-loop-helix(b HLH)transcription factor,differentiated embryonic chondrocyte gene 1(DEC1),in the apoptosis induced by 1-methyl-4-phenylpyridiniumion(MPP+)in SH-SY5Y cel...
关键词：differentiated embryonic chondrocyte gene 1 1-methyl-4-phenylpyridiniumion NEUROPROTECTION PI3K/Akt pathway 
Echinacoside Protects Against MPP+-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation被引量：19
《Neuroscience Bulletin》2016年第4期349-362,共14页Qing Zhao Xiaoyan Yang Dingfang Cai Ling Ye Yuqing Hou Lijun Zhang Jiwei Cheng Yuan Shen Kaizhe Wang Yu Bai 
supported by the National Natural Science Foundation of China(81202814);the Shanghai Municipal Commission of Health and Family Planning(20124y116);the Young Teachers Training Funding Scheme of Shanghai Colleges and Universities,China(zzszy12026)
Echinacoside （ECH） is protective in a mouse model of Parkinson＇ s disease （PD） induced by 1-methyl-4- phenylpyridinium ion （MPP＋）. To investigate the mechanisms involved, SH-SYSY neuroblastoma ceils were treat...
关键词：ECHINACOSIDE Parkinson＇s disease 1-Methyl-4-phenylpyridinium ion. Reactive oxygen species ATF3 CHOP 
全选清除导出
共3页<123>
检索报告 对象比较 聚类工具 使用帮助 返回顶部