6-TETRAHYDROPYRIDINE

作品数：32被引量：72H指数：5
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相关领域：医药卫生更多>>
相关作者：王辰李婉张珂雷慧陈生弟更多>>
相关机构：北京大学上海交通大学医学院附属瑞金医院上海第二医科大学蚌埠医学院第二附属医院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Neural Regeneration Research》《Chinese Medical Journal》《Medical Bulletin of Shanghai Jiaotong University》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家教育部博士点基金更多>>
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L-Ergothioneine ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in C57BL/6J mice by activating DJ-1
《Food Science and Human Wellness》2025年第3期1045-1061,共17页Xianshe Meng Huawen Meng Shuzeng Hou Zequn Yin Xuerui Wang Ke Gong Feng Zhang Qingshan Li Shuang Zhang Yuanli Chen Xiaoxiao Yang Zhiwei Zhao Chenzhong Liao Yajun Duan 
supported by the National Natural Science Foundation of China(U22A20272,82173807,82170497)。
Parkinson's disease(PD)is one of the most common neurodegenerative diseases.The loss of dopaminergic(DAergic)neurons in the substantia nigra and the decrease of dopamine(DA)levels accelerate the process of PD.L-Ergoth...
关键词：L-Ergothioneine 1-Methyl-4-phenyl-1 2 3 6-TETRAHYDROPYRIDINE Parkinson’s disease DJ-1 Dopaminergic neurons 
Multi-omics analysis reveals the neuroprotective effect of Atractylodis Rhizoma Alba extract against Parkinson's disease in mouse
《Journal of Traditional Chinese Medicine》2024年第6期1111-1117,共7页KANG Sohi LEE Soong-In MOON Byeong Cheol SONG Jun Ho KIM Sung-Ho MOON Changjong LEE Sueun KIM Chul KIM Joong Sun 
the Development of Sustainable Application for Standard Herbal Resource by the Korea Institute of Oriental Medicine (No. KSN2012320)。
OBJECTIVE: To assess Atractylodis Rhizoma Alba extract(ARE) neuroprotective function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice and related genes. METHODS: Examined m RNA-DNA methylation change...
关键词：Parkinson disease nerve degeneration 1-methyl-4-phenyl-1 2 3 6-TETRAHYDROPYRIDINE Atractylodis Rhizoma Alba Methyl-seq 
TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils被引量：1
《Neural Regeneration Research》2024年第6期1375-1384,共10页Tong Shen Guiyun Cui Hao Chen Long Huang Wei Song Jie Zu Wei Zhang Chuanying Xu Liguo Dong Yongmei Zhang 
supported by the National Natural Science Foundation of China,Nos.82271257(to YZ)and 82071228(to YZ);Qing Lan Project(to YZ);Open Competition Grant of Xuzhou Medical University(to YZ);Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX21_2705(to TS)。
Microglia-mediated neuroinflammation is considered a pathological feature of Parkinson's disease.Triggering receptor expressed on myeloid cell-1(TREM-1)can amplify the inherent immune response,and crucially,regulate i...
关键词：1-methyl-4-phenylpyridiniumion dopaminergic neurons infiltration 1-methyl-4-phenyl-1 2 3 6-TETRAHYDROPYRIDINE MICROGLIA NEUTROPHILS neuroinflammation Parkinson's disease SYK TREM-1 
Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease被引量：2
《Neural Regeneration Research》2024年第3期529-535,共7页Sandro Huenchuguala Juan Segura-Aguilar 
The positive effect of levodopa in the treatment of Parkinson’s disease,although it is limited in time and has severe side effects,has encouraged the scientific community to look for new drugs that can stop the neuro...
关键词：1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine 6-HYDROXYDOPAMINE aminochrome dopaminergic neurons DT-diaphorase exogenous neurotoxins glutathione transferase M2-2 
Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX-4 signaling pathway被引量：1
《Food Science and Human Wellness》2024年第1期414-420,共7页Zitian Gao Gaorui Wang Yujie Chen Wuke Yuan Jun Cai Aiping Feng Jie Fang Qi Xu Xiaojun Wu 
Parkinson’s disease(PD)is a common neurodegenerative disorder with no cure.Astragalus membranaceus is used in Chinese culture as a food supplement to boost immunity.The present study aimed to explore the neuroprotect...
关键词：Parkinson’s disease Total fl avonoids of Astragalus membranaceus Ferroptosis SLC7A11 
The transient receptor potential melastatin 2:a new therapeutical target for Parkinson's disease?被引量：4
《Neural Regeneration Research》2023年第8期1652-1656,共5页Ana Flávia F.Ferreira Luiz Roberto G.Britto 
funded by Coordination for the Improvement of Higher Education Personnel (CAPES,Brazil-Finance Code 001,to LRB);the S?o Paulo Research Foundation(FAPESP,Brazil,project#2018/07366-4);The National Council for Scientific and Technological Development (CNPq,Brazil,project#303006/2018-8,to LRB);a PhD fellowship from FAPESP under Grant Agreement No 2020/02109-3。
The transient receptor potential melastatin 2 is a calcium-permeable cation channel member of the TRP family. Also known as an oxidative stress-activated channel, the transient receptor potential melastatin 2 gating m...
关键词：1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine(MPTP) 1-methyl-4-phenylpyridinium(MPP+) 6-HYDROXYDOPAMINE AG490 CLOTRIMAZOLE flufenamic acid N-(p-amylcinnamoyl)anthranilic acid Parkinson's disease poly-ADPR polymerase type 1(PARP1) ROTENONE PARAQUAT transient receptor potential melastatin 2(TRPM2) 
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease被引量：10
《Neural Regeneration Research》2023年第8期1818-1826,共9页Hai-Yang Yu Tong Sun Zhen Wang Hong Li Duo Xu Jing An Lu-Lu Wen Jia-Yi Li Wen Li Juan Feng 
supported by the National Natural Science Foundation of China,Nos.81771271(to JF),31800898(to WL),81430025(to JYL),and U1801681(to JYL);Key Research and Development Program of Liaoning Province,No.2020JH2/10300047(to JF);the Key Field Research Development Program of Guangdong Province,No.2018B030337001(to JYL);the Outstanding Scientific Fund of Shengjing Hospital,No.M0475(to JF)。
Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus.Therefore,using these two treatments ...
关键词：diabetes mellitus dipeptidyl peptidase 4 inhibitor EXENDIN-4 glucagon-like peptide-1 receptor agonist 1-methyl-4-phenyl-1 2 3 6-TETRAHYDROPYRIDINE LINAGLIPTIN microglia NEUROINFLAMMATION NLRP3 inflammasome Parkinson's disease PYROPTOSIS 
Intestinal Dopamine Receptor D2 is Required for Neuroprotection Against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Dopaminergic Neurodegeneration被引量：2
《Neuroscience Bulletin》2022年第8期871-886,共16页Hairong Peng Shui Yu Yukai Zhang Yanqing Yin Jiawei Zhou 
This work was supported by grants from the Ministry of Science and Technology of China(2020YFC2002800);the Natural Science Foundation of China(U1801681);Strategic Priority Research Program of Chinese Academy of Science(XDB32020100);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Key Realm R&D Program of Guangdong Province(2018B030337001);Innovative Research Team of High-Level Local Universities in Shanghai.
A wealth of evidence has suggested that gastrointestinal dysfunction is associated with the onset and progression of Parkinson’s disease(PD).However,the mechanisms underlying these links remain to be defined.Here,we ...
关键词：INTESTINE DRD2 Parkinson’s disease MPTP SUCCINATE Mitochondria 
Nickel-catalyzed asymmetric arylative cyclization of N-alkynones:Efficient access to 1,2,3,6-tetrahydropyridines with a tertiary alcohol
《Chinese Chemical Letters》2021年第12期4038-4040,共3页Jiangyan Tian Wendian Li Ruihao Li Lin He Hui Lv 
financial support from the National Natural Science Foundation of China (Nos. 22071188, 21871212);the open foundation of CAS Key Laboratory of Molecular Recognition and Function, the "Double First-Class" Project of Shihezi University。
Nickel/(S)-t-Bu-PHOX complex catalyzed asymmetric arylative cyclization of N-alkynones has been achieved, delivering 1,2,3,6-tetrahydropyridines containing a chiral tertiary alcohol in high yields and excellent enanti...
关键词：Asymmetric catalysis ALKYNONES CYCLIZATION Nickel 
Epigenetic mechanisms involved in the neuroprotective effect of scorpion extract in a Parkinson's disease murine model based on multi-omics approach被引量：2
《Journal of Traditional Chinese Medicine》2021年第3期390-396,共7页Joong Sun Kim Hye-Sun Lim Byeong Cheol Moon Mary Jasmin Ang Sung-Ho Kim Changjong Moon Boseok Seong Yunji Jang Hyung-Yong Kim Chul Kim 
Supported by the Korea Institute of Oriental Medicine:the Verification of Efficacy and Safety for Chung-bu Medicinal Materials Described in the Dong Ui Bo Gam (K18411);Applicational Development of Standardized Herbal Resources (KSN1911420)。
OBJECTIVE: To investigate whether scorpion extract elicits a neuroprotective effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice models, and the genes associated with the therapeutic effects usin...
关键词：SCORPIONS 1-methyl-4-phenyl-1 2 3 6-TETRAHYDROPYRIDINE Parkinson disease DNA methylation 
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