Supported by Central Talent Training Project for the Reform and Development of Local Colleges and Universities(2020GSP16);Guidance Project of Key R&D Plan in Heilongjiang Province(GZ20220039).
Koumine is an indole alkaloid monomer extracted from the Chinese herb Gelsemium elegans,which has a variety of pharmacological effects.This paper provides a comprehensive summary of the pharmacological effects and mol...
A route to the total synthesis of koumine has been suggested.Five 4-substituted 1,2- dihydropyridine derivatives,which are supposed to be a conjugated diene of Diels-Alder reaction to produce the isoquinuclidine ring ...