FARNESYLTRANSFERASE

作品数：6被引量：5H指数：1
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相关领域：医药卫生更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》《Journal of Biophysical Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Pediatric fatty liver disease:Role of ethnicity and genetics被引量：5
《World Journal of Gastroenterology》2014年第23期7347-7355,共9页Pierluigi Marzuillo Emanuele Miraglia del Giudice Nicola Santoro 
Supported by The American Heart Association(13SDG14640038);2012 Yale Center for Clinical Investigation cholar award to Santoro N;This publication was also made possible by CTSA Grant Number UL1 RR024139 from the National Center for Advancing Translational Science,a component of the National Institutes of Health(NIH),and NIH roadmap for Medical Research,Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NIH
Non-alcoholic fatty liver disease (NAFLD) comprehends a wide range of conditions, encompassing from fatty liver or steatohepatitis with or without fibrosis, to cirrhosis and its complications. NAFLD has become the mos...
关键词：Non alcoholic fatty liver disease ETHNICITY Patatin like phospholipase containing domain 3 gene Obesity Insulin resistance Glucokinase regulatory protein Apolipoprotein C3 gene Farnesyl-diphosphate farnesyltransferase 1 
Expression of farnesyltransferase in primary liver cancer
《Chinese Medical Journal》2012年第14期2427-2431,共5页SUI Guo-de ZHANG Guang-yong NIU Zhao-jian HU San-yuan 
This work was supposed by a grant from the Natural Science Foundation of Shandong Province, China （No. Y2005C45）.
Background Primary liver cancer （PLC） is a common malignant tumor. Over the past decade, although farnesyltransferase （FTase） has emerged as a significant target for anticancer therapies and has become a hotspot o...
关键词：primary liver cancer  farnesyltransferase fluorescent quantitative-polymerase chain reaction 
Exploring MIA-QSARs for farnesyltransferase inhibitory effect of antimalarial compounds refined by docking simulations
《Journal of Biophysical Chemistry》2012年第1期58-71,共14页Omar Deeb Sherin Alfalah Matheus P. Freitas Elaine F. F. da Cunha Teodorico C. Ramalho 
Two series of farnesyltransferase (FTase) inhibitors were grouped and their antimalarial activi-ties modeled by means of multivariate image analysis applied to quantitative structure-activity relationship (MIA-QSAR). ...
关键词：ADMET Docking FARNESYLTRANSFERASE Inhibitors Malaria Multivariate Image Analysis-QSAR 
Synthesis of a Novel Series of S-Alkyl Thiobenzoate Compounds as Farnesyltransferase Inhibitors
《Chinese Chemical Letters》2005年第2期151-154,共4页ShengBiaoWAN JunFENG FengMingCHU ZongRuGUO 
This work was supported by National Basic Research Program(973 Program:G1998051102).
S-akyl thiobenzoate compounds were designed as farnesyltransferase (FTase) inhibitors.An effective synthetic method was explored. The structures of the target compounds wereelucidated by NMR spectral and elemental ana...
关键词：S-Akyl thiobenzoate compounds BENZODIAZEPINE farnesyltransferase. 
Synthesis of 3, 7-Disubstituted 1, 4-Benzodiazepin-2-one
《Chinese Chemical Letters》2002年第5期412-415,共4页ShengBiao ZongRuGUO 
A series of 3-methoxycarbonylpropoxy-7-(imidazol-4-ylpropinamide)-1, 3-dihydrogen- 1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-ones, as farnesyltransferase(Ftase) inhibitors, were synthesized. The preparation of the ke...
关键词：BENZODIAZEPINE farnesyltransferase. 
Ras farnesyltransferase inhibition: a novel and safe approach for cancer chemotherapy
《Acta Pharmacologica Sinica》2000年第5期14-22,共9页Srinivas NAMMI Durga Srinivas LODAGALA 
The 21-kDa Ras proteins are well known for their regulatory role in oncogenic, mitogenic, and developmental signaling pathways. GTP activated Ras interacts directly with the Raf protein to recruit the MAP kinases and ...
关键词：proto-oncogene protein p21 ( ras ) dimethylallyltranstransferase protein isoprenylation Ca2 +-calmodulin dependent protein kinase antineoplastic agents signal transduction 
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