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作品数：59被引量：153H指数：7
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相关领域：医药卫生农业科学更多>>
相关机构：癌症研究所更多>>
相关期刊：《Science China(Life Sciences)》《Chinese Journal of Integrative Medicine》《Nano-Micro Letters》《Acta Pharmacologica Sinica》更多>>
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Sanhuang Xiexin Decoction Ameliorates TNBC by Modulating JAK2-STAT3 and Lipid Metabolism
《Chinese Journal of Integrative Medicine》2024年第12期1080-1089,共10页QI Ying WU Xin-jie SHI Jing-bin SHI Xiao-wei ZHAO Na XIONG Yang WANG Li-pei 
Supported by Natural Science Foundation of Zhejiang Province(No.LY20C060002)。
Objective:To investigate the therapeutic effect of Sanhuang Xiexin Decoction(SXD)on triplenegative breast cancer(TNBC)in mice and its underlying mechanism.Methods:The high-performance liquid chromatography(HHLC)was us...
关键词：Sanhuang Xiexin Decoction Janus kinase 2-signal transducer and activator of transcription 3 lipid metabolism triple-negativebreast cancer epithelial-mesenchymal transition 
Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis
《Acta Pharmacologica Sinica》2024年第12期2672-2683,共12页Jing-nan Zhang Ze Zhang Zhen-lin Huang Qian Guo Ze-qi Wu Chuang Ke Bin Lu Zheng-tao Wang Li-li Ji 
supported by the"Young Qihuang Scholar"for Li-li Ji,National Natural Science Foundation of China(82273994);Program of Shanghai Academic Research Leader(23XD1404000);the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(2023YZZ02).
Triple-negative breast cancer(TNBC)is incurable and prone to widespread metastasis.Therefore,identification of key targets for TNBC progression is urgently needed.Our previous study revealed that isotoosendanin(ITSN)r...
关键词：TNBC isotoosendanin GOT2 MYH9 DRP1 mitochondrial fission 
Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy被引量：2
《Chinese Chemical Letters》2024年第10期348-352,共5页Lin Li Bingjun Sun jin Sun Lin Chen Zhonggui He 
supported by the National Nature Science Foundation of China(No.81803029);the Science and Technology Foundation of Yuzhong District,Chongqing(No.20210179);the Nature Science Foundation of Chongqing(No.cstc2021jcyjmsxmX1089)。
Chemotherapy has been recommended as the standard protocol for triple-negative breast cancer(TNBC)at the advanced stage.However,the current treatment is unsatisfactory due to inefficient drug accumulation and rapid ch...
关键词：Prodrug nanoassemblies PACLITAXEL Ferroptosis LAT1 Triple-negative breast cancer 
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A被引量：1
《Protein & Cell》2024年第10期744-765,共22页Dandan Feng Jie Gao Ruiqiong Liu Wei Liu Tianyang Gao Yunkai Yang Die Zhang Tianshu Yang Xin Yin Hefen Yu Wei Huang Yan Wang 
supported by grants from the National Natural Science Foundation of China(Grant Nos.41931291,42125707,81802816,81902882,and 82273403);Major State Basic Research Development Program of China(2022YFA1103402);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310027,2021-RC310-006);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-018).
Coactivator-associated arginine methyltransferase 1(CARM1)promotes the development and metastasis of estro-gen receptor alpha(ERa)-positive breast cancer.The function of CARM1 in triple-negative breast cancer(TNBC)is ...
关键词：CARM1 HIF1A CDK4 ellagic acid TNBC 
ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating PI3K/AKT/mTOR signaling
《Oncology Research》2024年第7期1209-1219,共11页XIA DA HAN GE JUNFENG SHI CHUNHUA ZHU GUOZHU WANG YUAN FANG JIN XU 
supported by Medical and Health Research Project of Nanjing Health Science and Technology Development Special Fund(ZKX21040).
Objective:This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2(ROR2)in triple-negative breast cancer(TNBC).Methods:ROR2 expression in primary TNBC and metastatic TNBC tissues was...
关键词：Receptor tyrosine kinase-like orphan receptor 2 Triplet-negative breast cancer Proliferation Apoptosis PI3K/AKT/mTOR signaling Metastasis 
Efficacy and safety of first-line treatment for metastatic triple-negative breast cancer:A network meta-analysis
《Cancer Pathogenesis and Therapy》2024年第2期81-90,共10页Mingqiang Shi Zhoujuan Li Guoshuang Shen Tianzhuo Wang Jinming Li Miaozhou Wang Zhen Liu Fuxing Zhao Dengfeng Ren Jiuda Zhao 
Background:Metastatic triple-negative breast cancer(mTNBC)is an aggressive histological subtype with poor prognosis.Several first-line treatments are currently available for mTNBC.This study conducted a network meta-a...
关键词：Metastatictriple-negativebreast cancer First-line treatment CHEMOTHERAPY Immune-checkpoint inhibitors Poly(ADP-Ribose)polymerase inhibitors AKT inhibitor Networkmeta-analysis 
The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells
《Acta Biochimica et Biophysica Sinica》2024年第4期564-575,共12页Qidi Huang Shurong Zheng Huayan Gu Zhi Yang Yiqiao Lu Xia Yu Guilong Guo 
supported by the grants from Zhejiang Provincial Health Department(No.2019KY454);Wenzhou Science and Technology Project(No.Y20210939).
Triple negative breast cancer(TNBC)has a high recurrence rate,metastasis rate and mortality rate.The aim of this study is to identify new targets for the treatment of TNBC.Clinical samples are used for screening deubi...
关键词：BRCC3 ZEB1 epithelial-mesenchymal transition triple negative breast cancer 
Ultrasound-responsive spherical nucleic acid against c-Myc/PD-L1 to enhance anti-tumoral macrophages in triple-negative breast cancer progression
《Science China(Life Sciences)》2024年第4期698-710,共13页Runtian Wang Gaigai Li Fangyan Gao Feng Xu Xintong Li Jian Zhang Jinbo Li Xiaoxiang Guan 
supported by the National Natural Science Foundation of China(81920108029,22077063,22322703);the Key Foundation for Social Development Project of Jiangsu Province of China(BE2021741)。
Triple-negative breast cancer(TNBC)is the most challenging breast cancer subtype because of its aggressive behavior and limited therapeutic targets.c-Myc is hyperactivated in the majority of TNBC tissues,however,it ha...
关键词：triple-negative breast cancer C-MYC spherical nucleic acid self-assembly 
A novel isoxazole compound CM2-II-173 inhibits the invasivephenotype of triple-negative breast cancer cells
《Oncology Research》2023年第6期867-875,共9页EUN SOOK KIM SANGHEE KIM AREE MOON 
supported by the National Research Foundation of Korea(Nos.2016R1A6A1A03007648,2019R1A2C1009773,2018R1A5A2024425,and 2022R1A2C1093335).
Invasion and metastasis are important hallmarks of breast cancer and are the leading cause of patient mortality.Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by a poor progn...
关键词：MMP-9 Cell invasion Breast cells 
Identification of a seven-gene signature and establishment of a prognostic nomogram predicting overall survival of triple-negative breast
《Cancer Advances》2023年第14期1-10,共10页Wan-Rong Li Jian Wang Xin Li 
Background: Triple-negative breast cancer (TNBC) is a highly heterogeneous breast cancersubtype characterized by the absence of expression of estrogen receptor (ER), progesteronereceptor (PR), and human epidermal grow...
关键词：triple-negative breast cancer prognostic model molecular heterogeneity personalized treatment cell cycle regulation 
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