Studying pup isolation calls of wild rodents provides background for developing new early-life animal models for biomedical research and drug testing.This study discovered a highly complex acoustic phenotype of pup is...
AIM: To investigate the ability of a genetically altered embryonic stem (ES) cell line to generate insulin-producing cells in vitro following transfer of the Nkx2.2 gene.METHODS: Hamster Nkx2.2 genes were transfer...
AIM: Lercanidipine is a new vasoselective dihydropyridine calcium channel blocker with a short plasma half-life, long duration of action, and demonstrated cardioprotective properties. We hypothesized that it might be ...
AIM: To determine in the hamster cheek pouch whether or not the changes in plasma extravasation induced by vascular endothelial growth factor (VEGF) could be affected by fructose diet. METHODS: Hamsters were subjected...
OBJECTIVE: To explore the role of natural killer T (NK T) cells in the pathogenesis of Graves' disease. METHODS: NK T cell deficient mice and wild BALB/c mice were immunized with cells expressing TSH receptor once eve...
OBJECTIVE: To verify whether the extracellular domain of kinase domain region (KDR) has anti-angiogenesis activity in vivo. METHODS: cDNA was cloned into adeno-associated virus (AAV) vector pSNAV and transfected to ba...
Supported by the National Natural Science Foundation of China(C39370805);Zhejiang Provincial Natural Science Foundation(300487);the Excellent Youth Scientist Fund of Zhejiang Province
AIM: To clone the cDNA of UGT1A9 from a Chinese human liver and establish the Chinese hamster lung (CHL) cell line expressing human UGT1A9. METHODS: cDNA of UGT1 A9 was transcripted from mRNA by reverse transcriptase-...