TIRAPAZAMINE

作品数：5被引量：1H指数：1
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相关领域：医药卫生更多>>
相关作者：蔡天宇更多>>
相关机构：浙江大学更多>>
相关期刊：《Journal of Cancer Therapy》《Science China Chemistry》《National Science Review》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Introducing urea into tirapazamine derivatives to enhance anticancer therapy
《National Science Review》2024年第4期239-247,共9页Yajun Xu Jianlin Lv Chaoying Kong Ya Liu Kun Wang Zhaohui Tang Xuesi Chen 
This work was supported by the Ministry of Science and Technology of China(2022YFE0110200);the National Natural Science Foundation of China(52025035);the Jilin Provincial International Cooperation Key Laboratory of Biomedical Polymers Grant(20210504001GH).
Tirapazamine(TPZ)has been approved for multiple clinical trials relying on its excellent anticancer potential.However,as a typical hypoxia-activated prodrug(HAP),TPZ did not exhibit survival advantages in Phase III cl...
关键词：TIRAPAZAMINE vascular disrupting agent hypoxia-activated prodrug combretastatin A4 UREA 
Vascular disrupting agent-induced amplification of tumor targeting and prodrug activation boosts anti-tumor efficacy被引量：1
《Science China Chemistry》2022年第10期1994-2004,共11页Sheng Hong Qian-Xiao Huang Ping Ji Xuan Pang Yunxia Sun Si-Xue Cheng Xian-Zheng Zhang Xuesi Chen 
supported by the National Natural Science Foundation of China (51988102,51833007,22135005,52173136 and 21721005)
Vadimezan,one of the typical vascular disrupting agents(VDAs) currently in clinical trials,has been extensively implemented for cancer research,whereas its clinical efficacy is adversely affected by the inevitable sid...
关键词：tumor therapy PRODRUG vascular disrupting agent TIRAPAZAMINE HYPOXIA 
Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques
《Acta Pharmaceutica Sinica B》2022年第4期2014-2028,共15页Mengqi Xu Cong Mao Haoting Chen Lu Liu Yabin Wang Abid Hussain Sulei Li Xu Zhang Ruslan G.Tuguntaev Xing-Jie Liang Weisheng Guo Feng Cao 
This work was supported by the National Nature Science Foundation of China(Nos.81820108019,91939303 and 31971302);the National Key Research and Development Program of China(2018YFC0116305);the Science Foundation of PLA General Hospital(2018XXFC-9,CX19028,China).
Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular event.Early detection and precise intervention of VASP hold great clinical significance,yet remain a major challenge.Phot...
关键词：Vulnerable atherosclerotic plaques Theranostic nanoprobe Human serum albumin OSTEOPONTIN Photodynamic therapy Hypoxia Reactive oxygen species TIRAPAZAMINE 
Tirapazamine encapsulated hyaluronic acid nanomicelles realized targeted and efficient photo-bioreductive cascading cancer therapy
《Chinese Chemical Letters》2021年第8期2400-2404,共5页Chunhui Wu Qiuyue Liu Yikun Wang Zhengxin Xie Honglin Huang Ningxi Li Xiaodan Wei Geng Yang Tingting Li Hong Yang Shun Li Xiang Qin Yiyao Liu 
supported,in part or in whole,by the National Natural Science Foundation of China (Nos.81471785,81671821,11772088,11802056,31800780,11972111,31900940,U19A2006,32071304);the Basic Research Program of Sichuan Science and Technology (Nos.2021YJ0130,2019YJ0183,2019YJ0184);China Postdoctoral Science Foundation (Nos.2018M640904,2019T120831);the Fundamental Research Funds for the Central Universities (No.ZYGX2019J117)。
Currently,architecting a ratio nal and efficient nanoplatform combing with multi-therapeutic modalities is highly obligatory for advanced cancer treatment.In order to remedy the self-limiting hypoxic dilemma of photod...
关键词：Hyaluronic acid PHOTOSENSITIZER Bioreductive prodrug Hypoxia Cascading cancer therapy 
Effect of Tirapazamine and Mild Temperature Hyperthermia on the Recovery from Radiation-Induced Damage in Pimonidazole-Unlabeled Quiescent Tumor Cell Population
《Journal of Cancer Therapy》2013年第2期521-528,共8页Shin-Ichiro Masunaga Yoshinori Sakurai Hiroki Tanaka Minoru Suzuki Natsuko Kondo Masaru Narabayashi Keizo Tano Akira Maruhashi Koji Ono 
The aim in this study is to examine the effect of tirapazamine (TPZ) and mild temperature hyperthermia (MTH) on the repair of radiation-induced damage in pimonidazole-unlabeled quiescent (Q) tumor cells. Labeling of p...
关键词：Quiescent Cell RECOVERY from Radiation-Induced Damage TIRAPAZAMINE PIMONIDAZOLE MILD TEMPERATURE HYPERTHERMIA 
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