ANTITRYPSIN

作品数：26被引量：55H指数：4
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相关领域：医药卫生更多>>
相关作者：周昂更多>>
相关机构：北京大学肿瘤医院四川大学更多>>
相关期刊：《Journal of Clinical and Translational Hepatology》《Science Bulletin》《Journal of Acute Disease》《Chinese Journal of Cancer Research》更多>>
相关基金：北京市自然科学基金国家重点基础研究发展计划国家自然科学基金更多>>
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Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease
《Journal of Clinical and Translational Hepatology》2024年第10期845-856,共12页Naweed Mohammad Regina Oshins Tongjun Gu Virginia Clark Jorge Lascano Naziheh Assarzadegan George Marek Mark Brantly Nazli Khodayari 
sponsored by a grant from the Alpha-1 Foundation(AGR00019116).
Background and Aims:Alpha-1 antitrypsin deficiency(AATD)is a genetic disorder characterized by the misfolding and accumulation of the mutant variant of alpha-1 antitrypsin(AAT)within hepatocytes,which limits its acces...
关键词：Alpha-1 antitrypsin deficiency Chronic obstructive pulmonary disease Liver fibrosis Liver biopsy Liver histology TRANSCRIPTOMICS 
Alpha-1 antitrypsin deficiency and Pi^(*)Z allele as important co-factors in the development of liver fibrosis
《World Journal of Hepatology》2024年第8期1099-1110,共12页Ana Isabel Ferreira Catarina Guimarães Vitor Macedo Silva Sofia Xavier Joana Magalhães JoséCotter 
BACKGROUND Alpha-1 antitrypsin deficiency(AATD)is a codominant autosomal hereditary condition that predisposes patients to the development of lung and/or liver disease,and Pi*Z allele is the most clinically relevant m...
关键词：Alpha-1 antitrypsin deficiency Liver fibrosis Nonalcoholic fatty liver disease fibrosis score Fibrosis-4 index Liver stiffness measurement 
Role of biomarkers in community-acquired pneumonia management
《Journal of Acute Disease》2024年第3期87-92,共6页Bahaeddin Onur Hakan BarışDemirbas Arif Gulmez 
Community-acquired pneumonia(CAP)poses a significant global health threat,particularly affecting vulnerable populations.Biomarkers and scoring systems play a crucial role in diagnosing,assessing severity,and guiding t...
关键词：CURB-65 Community-acquired pneumonia PROCALCITONIN Alpha-1 antitrypsin Serum amyloid A 
Liver disease epidemiology and burden in patients with alterations in plasma protein metabolism:German retrospective insurance claims analysis
《World Journal of Hepatology》2023年第10期1127-1139,共13页Nils Picker May Hagiwara Severin Baumann Ed G Marins Thomas Wilke Kaili Ren Ulf Maywald ChitraKarki Pavel Strnad 
BACKGROUND Alpha-1 antitrypsin deficiency is a rare genetic disease and a leading cause of inherited alterations in plasma protein metabolism(APPM).AIM To understand the prevalence,burden and progression of liver dise...
关键词：Alpha-1 antitrypsin deficiency EPIDEMIOLOGY Germany Liver diseases Retrospective study 
Hereditary hemochromatosis:Temporal trends,sociodemographic characteristics,and independent risk factor of hepatocellular cancer–nationwide population-based study被引量：1
《World Journal of Hepatology》2022年第9期1804-1816,共13页Maryam Bilal Haider Ali Al Sbihi Ahmed Jamal Chaudhary Syed M Haider Ahmed Iqbal Edhi 
BACKGROUND Hereditary hemochromatosis(HH)has an increased risk of hepatocellular cancer(HCC)both due to genetic risks and iron overload as iron overload can be carcinogenic;HH impacts the increasing risk of HCC,not on...
关键词：Hereditary hemochromatosis Hepatocellular carcinoma cirrhosis Hepatitis Diabetes mellitus Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Wilson disease Alpha1-antitrypsin deficiency Blood transfusion Epidemiology Demographics Big data HOSPITALIZATION 
白及颗粒对慢性阻塞性肺疾病模型大鼠肺组织α-1 antitrypsin、Neutrophil Elastase及MPO表达的影响被引量：4
《天津中医药》2021年第2期233-239,共7页程芳 武尚亮 赵丽华 
北京市自然科学基金项目(7124384)。
[目的]研究白及颗粒对大鼠慢性阻塞性肺疾病(COPD)横型的治疗作用及作用机制。[方法]60只SPF级SD大鼠分为空白对照组、模型对照组、羧甲司坦片组(0.14 g/kg)、白及颗粒高剂量组(5.4 g生药/kg)、白及颗粒中剂量组(3.6 g生药/kg)、白及颗...
关键词：白及颗粒 慢性阻塞性肺疾病 α-抗胰蛋白酶 中性粒细胞弹性蛋白酶 髓过氧化物酶 
Associations of Polymorphism of rs9944155, rs1051052, and rs1243166 Locus Allele in Alpha-1-antitrypsin with Chronic Obstructive Pulmonary Disease in Uygur Population of Kashgar Region被引量：3
《Chinese Medical Journal》2018年第6期684-688,共5页Xue-Mei Zhong Li Li Huai-Zhen Wang Xiao-Guang Zou Ping Zhang Mireban Rexiati Maimaitiaili Tnerxun Jie Ren Mukeremu Yasen Juan Zhang Ai-Fang Zheng Paierda Aini 
Background： Previous studies conducted in various geographical and ethnical populations have shown that Alpha-1 -antitrypsin （Alpha-1-AT） expression affects the occurrence and progression of chronic obstructive puh...
关键词：Alpha-1-antitrypsin Chronic Obstructive Pulmonary Disease POLYMORPHISM Uygur Population 
Managing panniculitis in alpha-1 antitrypsin deficiency: Systematic review of evidence behind treatment
《World Journal of Dermatology》2018年第1期1-8,共8页Donah K Sabbagh Behrad Barmayehvar Thanh Nguyen Ross G Edgar Alice M Turner 
AIM To systematically review literature for management of alpha-1 antitrypsin deficiency(AATD) panniculitis. METHODS Multiple databases were searched using combinations of pertinent terms. Articles were selected descr...
关键词：Alpha-1 ANTITRYPSIN DEFICIENCY Dermatological TREATMENT PANNICULITIS DAPSONE Augmentation therapy 
On the Activities of Pancreatic Proteases and Alpha-1 Proteinase Inhibitor in Meat-Type Chicken
《Open Journal of Animal Sciences》2017年第3期289-296,共8页Vladimir G. Vertiprakhov Alena A. Grozina Ivan A. Egorov Tatiana N. Lenkova Vardges A. Manukyan Tatiana A. Egorova 
The study was aimed at the evaluation of the effects of breed, age, different digestion stimulators, and dietary crude protein (CP) level on the activities of proteolytic enzymes in pancreatic tissue and duodenal chym...
关键词：CHICKS Pancreas TRYPSIN Alpha-1 PROTEINASE Inhibitor (Antitrypsin) Serum DUODENAL Fluid 
Phenotyping emphysema and airways disease: Clinical value of quantitative radiological techniques被引量：1
《World Journal of Respirology》2017年第1期1-16,共16页Diana Crossley Alice Turner Deepak Subramanian 
The pathophysiology of chronic obstructive pulmonary disease(COPD) and Alpha one antitrypsin deficiency is increasingly recognised as complex such that lung function alone is insufficient for early detection, clinical...
关键词：Chronic OBSTRUCTIVE pulmonary disease Alpha one ANTITRYPSIN deficiency Computed tomography DENSITOMETRY Phenotype SPIROMETRY Magnetic resonance imaging 
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