STRUCTURE-ACTIVITYRELATIONSHIP

作品数：3被引量：2H指数：1
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Carbon Chain Length Determines Inhibitory Potency of Perfluoroalkyl Sulfonic Acids on Human Placental 3β-Hydroxysteroid Dehydrogenase 1:Screening,Structure-Activity Relationship,and In Silico Analysis
《Biomedical and Environmental Sciences》2023年第11期1015-1027,共13页TANG Lu Ming MAO Bai Ping ZHANG Bing Ru LI Jing Jing TANG Yun Bing LI Hui Tao GE Ren Shan 
Objective This study aimed to compare 9 perfluoroalkyl sulfonic acids(PFSA)with carbon chain lengths(C4–C12)to inhibit human placental 3β-hydroxysteroid dehydrogenase 1(3β-HSD1),aromatase,and rat 3β-HSD4 activitie...
关键词：3β-hydroxysteroid dehydrogenase 1 Docking analysis Perfluorooctanesulfonic acid PROGESTERONE STRUCTURE-ACTIVITYRELATIONSHIP 
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Rafv600E inhibitors
《Acta Pharmacologica Sinica》2017年第7期1059-1068,共10页Gui-min WANG Xiang WANG Jian-ming ZHU Bin-bin GUO Zhuo YANG Zhi-jian XU Bo LI He-yao WANG Ling-hua MENG Wei-liang ZHU Jian DING 
This work was supported by the National Natural Science Foundation of China （81273435, 81302699 and 81321092）, the National Science and Technology Major Project （2013ZX09103001001）, the Ministry of Science and Technology （2012AA01A305）, the Natural Science Foundation of Shanghai, China （14ZR1447800）, the State Key Laboratory of Natural and Biomimetic Drugs （K20150205） and the Special Program for Applied Research on Super Computation of the NSFC-Guang- dong Joint Fund （the second phase）.
The mutation of B-Rafv600E is widespread in a variety of human cancers. Its inhibitors vemurafenib and dabrafenib have been launched as drugs for treating unresectable melanoma, demonstrating that B-Rafv600E is an ide...
关键词：B-Rafv600E inhibitor anticancer VEMURAFENIB deazapurine fragment reassembly molecular docking STRUCTURE-ACTIVITYRELATIONSHIP 
Rhodanine derivatives as novel peroxisome proliferator-activated receptor γ agonists被引量：2
《Acta Pharmacologica Sinica》2007年第12期2033-2039,共7页Qing LIU Yue-yun ZHANG Hui-li LU Qun-yi LI Cai-hong ZHOU Ming-wei WANG 
Project supported in part by grants from the Shanghai Municipality Science and Technology Development Fund(№ 05dZ22914 and 06DZ22907);the Ministry of Science and Technology(№ 2004CB518902)
Aim： To characterize the in vitro bioactivities of rhodanine derivatives as novel peroxisome proliferator-activated receptor （PPAR） Y modulators, based on a hit （SH0001267l） identified during high-throughput scre...
关键词：rhodanine derivatives peroxisome proliferator-activated receptor STRUCTURE-ACTIVITYRELATIONSHIP ADIPOGENESIS 
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