FENOTEROL

作品数：4被引量：9H指数：2
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相关领域：医药卫生更多>>
相关作者：胥婕王伟李晓光更多>>
相关机构：北京大学第三医院南通大学更多>>
相关期刊：《中国处方药》《Acta Pharmacologica Sinica》《国外药讯》更多>>
相关基金：国家重点基础研究发展计划国家自然科学基金更多>>
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Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives被引量：2
《Acta Pharmacologica Sinica》2019年第8期1095-1105,共11页Yiu-Ho Woo Xin-yue Ge Li Pan Gang Xing Yong-mei Mo Rui-juan Xing Xiao-ran Li Yu-yang Zhang Irving W. Wainer Mao-sheng Cheng Rui-ping Xiao 
We thank Dr. Joseph Kozocas from SRI international, California, USA for providing (R,/T)-FEN and (&R1-MNF for the analysis and Dr. Wei Liang and his team from WuXi AppTec, Shanghai, China for technical assistance in the cAMP assay. This work was supported by the Ministry of Science and Technology of the People's Republic of China under the National Key Research and Development Program of China [grant number 2018YFA0507603 (to R-PX)];the National Science and Technology Major Project [grant numbers 2013ZX09507001-001002 (to AY-HW), 2013ZX09301305-001 (to LP), 2013ZX09508104 (to R-PX), 2018ZX09739009 (to M-SC)];the National Basic Research Program [grant number 2012CB518000 (to R-PX)];the National Natural Science Foundation of China [grant numbers 81673355 (to AY-HW), 81872752 (to MSC), 31521062, 81630008, 81790621 (to R-PX)];Beijing Municipal Science & Technology Commission [grant number Z171100000417006 (to R-PX)], and the intramural research program of the NIH, USA (to IWW).
β-Arrestins are a small family of proteins important for signal transduction at G protein-coupled receptors (GPCRs).β-Arrestins are involved in the desensitization of GPCRs. Recently, biased ligands possessing diffe...
关键词：β2-adrenoceptor AGONISTS cAMP Β-ARRESTIN biased AGONISM FENOTEROL SALMETEROL heart failure asthma 
Fenoterol, a β2-adrenoceptor agonist, inhibits LPS- induced membrane-bound CD14, TLR4/CD14 complex, and inflammatory cytokines production through β-arrestin-2 in THP-1 cell line被引量：7
《Acta Pharmacologica Sinica》2009年第11期1522-1528,共7页Wei WANG Ming XU You-yi ZHANG Bei HE 
Acknowledgements Project was supported by the National Key Basic Research Program （NKBRP） of People＇s Republic of China （No 2006CB503806） and the National Natural Science Foundation of China （No 30770939 and 30821001）. The authors would like to thank Dr Laura HERATY for language revision, and Dr Pei ZHANG for performing the confocal laser scanning microscope.
Aim To investigate the molecular mechanism and signaling pathway by which fenoterol, a β2-adrenergic receptor （β2-AR） agonist, produces anti-inflammatory effects. Methods： THP-1, a monocytic cell line, was used t...
关键词：β2-adrenoceptor toll-like receptors β-arrestin-2 FENOTEROL confocal microscopy lipopolysaccharide 
多因素影响下的流行病学研究
《中国处方药》2008年第4期69-71,共3页Neil Pearce 黄艳 
1988年4月8日,星期五,上午10:30,当笔者正在新西兰惠灵顿的办公室里工作时,一位不速之客来访,告诉笔者非诺特罗(fenoterol)这种药物很可能在新西兰引起哮喘死亡率的增加。2年后,在流行病学专家的努力下,新西兰严格控制使用非诺特罗,其...
关键词：流行病学专家 美国食品药品监督管理局 FENOTEROL 非诺特罗 Β受体激动剂 哮喘药物 国际医学期刊 药物流行病学 
04048 Berodual Respimat令患者满意
《国外药讯》2006年第4期22-22,共1页曹菊（摘） 
在丹麦哥本哈根举办的第15届欧洲呼吸协会（ERS）年会上公布的一项调查结果显示，哮喘和慢性阻塞性肺病（COPD）患者对Boehringer Ingelheim公司的Berodual Respimat（ipratropium bromide／fenoterol，异丙托溴铵／非诺特罗）软雾吸入...
关键词：患者满意 慢性阻塞性肺病(COPD) FENOTEROL 异丙托溴铵 调查结果 非诺特罗 吸入剂 
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