PREDISPOSITION

作品数：53被引量：112H指数：6
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相关作者：王军张馨王刚陈生弟万赢更多>>
相关机构：首都医科大学上海交通大学上海交通大学医学院附属瑞金医院更多>>
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Consumption of sugary beverages,genetic predisposition and the risk of depression:a prospective cohort study
《General Psychiatry》2024年第4期463-472,共10页Yanchun Chen Hongxi Yang Baihe Sheng Lihui Zhou Dun Li Mengnan Zhang Yaogang Wang 
supported by National Natural Science Foundation of China(7191010700,91746205).
Background The associations between sugary beverages and genetic predisposition to depression risk remain unclear.Aims This study aimed to investigate the associations of sugar-sweetened beverages(SSBs),artificially s...
关键词：SUGAR BEVERAGE PREDISPOSITION 
Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis
《Journal of Genetics and Genomics》2023年第10期807-812,共6页Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu 
supported by grants from the National Natural Science Foundation of China,China(Nos.81870397,82000534,and 82073156);Shenzhen Kangzhe Pharmaceutical Co.Ltd,China(URC-126/PBC);The Fifth Suzhou Health Talent Project(GSWS201903);The Suzhou Radiotherapy Clinical Medical Center Project,Suzhou,Jiangsu,China(Szlcyxzx202103).
Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure wi...
关键词：CHOLANGITIS BILIARY 
Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts
《Portal Hypertension & Cirrhosis》2023年第3期115-126,共12页Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) 
Clinical Research Plan of SHDC,Grant/Award Number:SHDC2020CR1037B;Shanghai Municipal Key Clinic Specialty,Grant/Award Number:shslczdzk00602;National Key R&D Program of China,Grant/Award Number:2017YFC0908100;National Science and Technology Major Project,Grant/Award Numbers:2018ZX10302206,2018ZX10723203,2017ZX10202202;Shanghai Municipal Education Commission–Guofeng Clinical Medicine Grant Support,Grant/Award Number:20152213;National Natural Science Foundation of China,Grant/Award Numbers:82170629,81930061,81900579,81970550,82070613,82070650,81972265,81870425,81774234;Shanghai Hospital Development Commission,Grant/Award Number:16CR1024B;Chongqing Natural Science Foundation,Grant/Award Number:CSTC2019jcyjzdxmX0004;Beijing Municipal Science&Technology Commission,Grant/Award Number:Z191100006619033;Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program,Grant/Award Number:2017BT01S131;Clinical Research Program of Nanfang Hospital,Southern Medical University,Grant/Award Numbers:2018CR037,2020CR026;Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education,Grant/Award Number:LC2019ZD006;President Foundation of Nanfang Hospital,Southern Medical University,Grant/Award Number:2019Z003;Foundation for Innovative Research Groups of Hubei Provincial Natural Science Foundation,Grant/Award Number:2018CFA031;Hubei Province's Outstanding Medical Academic Leader Program and Project of Hubei University of Medicine,Grant/Award Numbers:FDFR201902,2020XGFYZR05;Fundamental Research Funds for the Central Universities,Grant/Award Number:2021FZZX001-41;Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2020A1515010052;Natural Fund of Guangdong Province,Grant/Award Number:2016A030313237;Guangzhou City Science and Technology Project,Grant/Award Number:201607010064。
Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.M...
关键词：cirrhosis PRECIPITANT prior decompensation short‐term mortality 
Wnt genes in colonic polyposis predisposition
《Genes & Diseases》2023年第3期753-757,共5页Isabel Quintana Mariona Terradas Pilar Mur Iris B.A.Wte Paske Sophia Peters Isabel Spier Verena Steinke-Lange Claudia Maestro David Torrents Montserrat Puiggròs Romina Royo Raul Tonda Genís Parra Davide Piscia Sergi Beltrán Matilde Navarro Virginia Piñol Joan Brunet Noemi Gonzalez-Abuin Gemma Aiza Anna Sommer Yasmijn van Herwaarden Galuh Astuti Elke Holinski-Feder Nicoline Hoogerbrugge Richarda Mde Voer Stefan Aretz Gabriel Capellá Laura Valle 
funded by the Spanish Ministry of Science and Innovation(Agencia Estatal de Investigación);co-funded by FEDER funds a way to build Europe[No.SAF2016-80888-R(LV),PID2020-112595RB-I00(LV),and PID2019-111254RB-I00(GC),and predoctoral fellowship“Formación de Personal Investigador”(IQ)];Instituto de Salud Carlos III[CIBERONC CB16/12/00234,Sara Borrell Postdoctoral contract(PM)];Government of Catalonia,Spain[PERIS MedPerCan,AGAUR 2017SGR1282,CERCA Program for institutional support];Scientific Foundation“Asociación Española Contra el Cáncer”[AECC Investigador(MT)];Marie Skłodowska-Curie Individual Fellowship[Organ-VIP,Grant agreement No.897064(NG-A)];The Solve-RD project is funded by the European Union's Horizon 2020 research and innovation program under grant agreement No.779257;This study was supported by the European Reference Network on Genetic Tumor Risk Syndromes(ERN GENTURIS)-Project ID No.739547(www.genturis.eu);the COST action CA17118;supported by COST(European Cooperation in Science and Technology).
Much of the genetic predisposition to polyposis,and particularly to serrated polyposis(SP),remains unknown.Only germline pathogenic variants in RNF43,a tumor suppressor that exerts negative feedback in the Wnt/β-cate...
关键词：POLYPOSIS SUPPRESSOR COLORECTAL 
Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies被引量：1
《Frontiers of Medicine》2022年第3期459-466,共8页Daijing Nie Jing Zhang Fang Wang Xvxin Li Lili Liu Wei Zhang Panxiang Cao Xue Chen Yang Zhang Jiaqi Chen Xiaoli Ma Xiaosu Zhou Qisheng Wu Ming Liu Mingyue Liu Wenjun Tian Hongxing Liu 
supported by a grant from the Shandong Nature Science Fund(No.ZR2016HP02).
Whether Fanconi anemia(FA)heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting.We retrospectively analyzed rare poss...
关键词：Fanconi anemia aplastic anemia hematologic malignancy germline predisposition 
The mutation landscape of multiple cancer predisposition genes in Chinese familial/hereditary breast cancer families被引量：1
《Cancer Biology & Medicine》2022年第6期850-870,共21页Li Dong Hailian Zhang Huan Zhang Yingnan Ye Yanan Cheng Lijuan Li Lijuan Wei Lei Han Yandong Cao Shixia Li Xishan Hao Juntian Liu Jinpu Yu 
This work was supported by the National Natural Science Foundation of China(Grant Nos.82072588,82002601,81872143,and 81702280);the National Science and Technology Support Program of China(Grant Nos.2015BAI12B15 and 2018ZX09201015);the National Key Research and Development Program of China;the Net Construction of Human Genetic Resource Bio-bank in North China(2016YFC1201703),the Projects of Science and Technology of Tianjin(Grant Nos.13ZCZCSY20300 and 18JCQNJC82700);the Key Project of Tianjin Health and Family Planning Commission(Grant No.16KG126).
Objective:Approximately 5%–10%of breast cancer(BC)patients display familial traits that are genetically inherited among the members of a family.The purpose of this study was to profile the germline mutations in 43 ge...
关键词：Familial breast cancer predisposition genes DNA damage repair genes clinical features 
Germline predisposition to soft tissue sarcoma
《Journal of Cancer Metastasis and Treatment》2022年第1期265-280,共16页Jennie Vagher Matthew S.Dietz Joshua D.Schiffman Wendy Kohlmann Luke Maese 
This manuscript utilized the Genetic Counseling Shared Resource at Huntsman Cancer Institute at the University of Utah and was supported by the National Cancer Institute of the National Institutes of Health under Award Number P30CA042014;JDS holds the Helen Clise Presidential Endowed Chair in Li Fraumeni Syndrome Research(University of Utah)and is the Co-Founder/CEO of Peel Therapeutics,Inc.
Soft tissue sarcoma(STS)most often occurs sporadically,but can also arise in the setting of a germline cancer predisposition syndrome(CPS).There is significant diversity amongst STS diagnoses as these tumors exhibit a...
关键词：GENETIC soft tissue sarcoma Li-Fraumeni syndrome cancer predisposition syndrome 
A multicenter study assessing the prevalence of germline genetic alterations in Chinese gastric-cancer patients被引量：1
《Gastroenterology Report》2021年第4期339-349,I0002,共12页Yin-Jie Zhang Yang Yang Qing Wei Ting Xu Xiao-Tian Zhang Jing Gao Si-Yi Tan Bao-Rui Liu Jing-Dong Zhang Xiao-Bing Chen Zhao-Jie Wang Meng Qiu Xin Wang Lin Shen Xi-Cheng Wang 
Background Approximately 10%of patients with gastric cancer(GC)have a genetic predisposition toward the disease.However,there is scant knowledge regarding germline mutations in predisposing genes in the Chinese GC pop...
关键词：familial gastric cancer next-generation sequencing germline mutation cancer-predisposition gene 
Implication of the LINGO2 gene in the predisposition to movement disorders
《Brain Science Advances》2021年第4期257-262,共6页Gita Vita Soraya Zulvikar Syambani Ulhaq Christian Peinado Garcia 
Previous reports on the pathogenesis of age-related movement disorders,such as Parkinson’s disease(PD)and essential tremor(ET),have demonstrated the potential implications of LINGO1(leucine-rich repeat and immunoglob...
关键词：LINGO2 Parkinson’s disease essential tremor movement disorder 
Predisposition of Obesity through Genetic and Non-Genetic Risk Factors
《Journal of Endocrinology Research》2020年第2期27-30,共4页Alice Jayapradha Cheekurthy 
Globally there is an increase in the number of people affected by obesity.This has increased the count of individuals to double,triple,and even quadruple.Obesity is a complex disease that has a genetic,behavioural,soc...
关键词：OBESITY Risk factor Type 2 diabetes mellitus 
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