CAMKII

作品数：94被引量：274H指数：10
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相关领域：医药卫生更多>>
相关作者：曹晓华徐浩刘汝清刘建功白杰云更多>>
相关机构：中国医科大学浙江大学华中科技大学华东师范大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金福建省自然科学基金更多>>
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Dip2a regulates stress susceptibility in the basolateral amygdala
《Neural Regeneration Research》2025年第6期1735-1748,共14页Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu 
supported by the STI 2030—Major Projects 2021ZD0204000,No.2021ZD0204003 (to XZ);the National Natural Science Foundation of China,Nos.32170973 (to XZ),32071018 (to ZH)。
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types...
关键词：5-HYDROXYTRYPTAMINE acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics NEUROTRANSMITTERS principal component analysis stress susceptibility TRYPTOPHAN 
Integrative transcriptomic and proteomic analysis reveals that SERPING1 inhibits neuronal proliferation via the CaMKII-CREB-BDNF pathway in schizophrenia
《World Journal of Psychiatry》2025年第2期193-208,共16页Feng Li Xing Ren Jia-Xiu Liu Tian-Dao Wang Bi Wang Xiao-Bin Wei 
Supported by the Key R&D Projects of Hainan Province,No.ZDYF2022SHFZ295.
BACKGROUND Schizophrenia(SZ),a chronic and widespread brain disorder,presents with complex etiology and pathogenesis that remain inadequately understood.Despite the absence of a universally recognized endophenotype,pe...
关键词：TRANSCRIPTOMICS Proteomics SCHIZOPHRENIA SERPING1 Pathogenesis 
Emerging Role of CaMKII as a Possible Therapeutic Target for Cardiovascular Diseases
《World Journal of Cardiovascular Surgery》2024年第12期191-220,共30页Suvechha Bhandari Terry Oroszi 
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of heart function. While some CaMKII activity is beneficial, excessive, or persistent, CaMKII can lead to heart damage. CaMKII is often elevat...
关键词：CAMKII Cardiovascular Diseases Heart Failure ARRHYTHMIAS DIABETES Inflammation Cardiac Remodeling Ion Channels Therapeutic Target Drug Development 
Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases
《Journal of Pharmaceutical Analysis》2024年第11期1661-1674,共14页Yongjing Zhang Yingnan Zeng Haoyun Bai Wen Zhang Zhuoyin Xue Shiling Hu Shemin Lu Nan Wang 
funded by National Natural Science Foundation of China(Grant Nos.:81930096 and 82274063).
Allergic inflammation is closely related to the activation of mast cells(MCs),which is regulated by its intracellular Ca^(2+) plevel,but the intake and effects of the intracellular Ca^(2+) premain unclear.The Ca^(2+) ...
关键词：ALLERGY ASTHMA Mast cell CaV1.2 CaMKII/PKC 
The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking
《Neuroscience Bulletin》2024年第11期1649-1666,共18页En Ji Yuanyuan Zhang Zhiqiang Li Lai Wei Zhaofa Wu Yulong Li Xiang Yu Tian‑Jia Song 
supported by grants from the National Natural Science Foundation of China(32030049 and 82101619);the Ministry of Science and Technology of China(2021ZD0202500);the Key-Area Research and Development Program of Guangdong Province(2019B030335001);the Qidong-SLS Innovation Fund(to X.Y.)。
The CC chemokine ligand 2(CCL2,also known as MCP-1)and its cognate receptor CCR2 have wellcharacterized roles in chemotaxis.CCL2 has been previously shown to promote excitatory synaptic transmission and neuronal excit...
关键词：Synaptic transmission CCL2 MCP-1 CCR2 CAMKII AMPA receptor GluA1 
Compound heterozygous mutations of NTNG2 cause intellectual disability via inhibition of the CaMKII signaling
《Journal of Genetics and Genomics》2024年第11期1204-1214,共11页Yaoting Chen Jiang Chen Lili Liang Weiqian Dai Nan Li Shuangshuang Dong Yongkun Zhan Guiquan Chen Yongguo Yu 
National Key R&D Program of China(2022YFC2703400 to Y.G.Y.);National Natural Science Foundation of China(82001209 to S.S.D.,82271904 and 82070914 to Y.G.Y.);Shanghai Municipal Commission of Health and Family Planning(20204Y0451 to S.S.D.);Shanghai Scientific and Technological Innovation Action Plan(20YF1440600 to S.S.D.);Shanghai Natural Science Foundation of China(21ZR1452700 to Y.K.Z.)。
Netrin-G2 is a membrane-anchored protein known to play critical roles in neuronal circuit development and synaptic organization.In this study,we identify compound heterozygous mutations of c.547delC p.(Arg183Alafs*186...
关键词：CaMKII signaling Intellectual disability NTNG2 Synaptic plasticity Learning and memory 
Desipramine reverses remote memory deficits by activating calmodulin- CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome
《General Psychiatry》2024年第5期522-531,共10页Lei Chen Yuting Li Minggang Liu Zhaohui Lan Xu Zhang Xiujuan Yang Qian Zhao Shuai Wang Longyong Xu Ying Zhou Yifang Kuang Tatsuo Suzuki Katsuhiko Tabuchi Eiki Takahashi Miou Zhou Charlie Degui Chen Tianle Xu Weidong Li 
supported by STI2030-Major Projects(2022ZD0204900);the National Natural Science Foundation of China(NSFC)(91632103,31900732,31771157);the Program of Shanghai Subject Chief Scientist(17XD1401700);National Key Research and Development Program of China(2018YFE0126700);the Shanghai Education Commission Research and Innovation Program(2019-01-07-00-02-E00037);Natural Science Foundation of Chongqing cstc2021jcyjmsxmX1176,the‘111’Program of Higher Education Discipline Innovation,‘Eastern Scholar’(Shanghai Municipal Education Commission),Shanghai Municipal Commission of Science and Technology Program(21dz2210100);China Postdoctoral Science Foundation(202N1702133,2021M702137);The National Science Fund for Distinguished Young Scholars(31900732).
Background Kabukisyndrome(KS)is arare developmental disorder characterised by multiple congenital anomalies and intellectual disability.UTX(ubiquitously transcribed tetratricopeptide repeat,X chromosome),which encodes...
关键词：IMPAIRED reversed UTX 
柴金解郁安神片调控CaMKII和Cofilin双信号通路改善抑郁症海马谷氨酸能神经元突触重塑
《中国药理学通报》2024年第8期1523-1532,共10页刘检 唐林 赵洪庆 刘林 杨蕙 李薇 孟盼 王宇红 
国家重大新药创制科技重大专项资助项目(No.2017ZX09309026);国家自然科学基金资助项目(No.82104793);湖南省自然科学基金资助项目(No.2022JJ30451);湖南省卫健委科研计划项目(No.W20243072);湖南省三尖创新人才“湖湘青年英才”项目(No.2022RC1226)。
目的探讨柴金解郁安神片调控钙/钙调蛋白依赖性蛋白激酶Ⅱ(CaMKII)和Cofilin双信号通路,改善抑郁症海马谷氨酸能神经元突触重塑的分子机制。方法皮质酮联合脂多糖建立抑郁症体外细胞模型,实验设正常组、模型组、GR阻断剂组、GR激动剂组...
关键词：抑郁症 谷氨酸能神经元 突触重塑 NR/CaMKII MK2/Cofilin 柴金解郁安神片 
视动反应中PF-PC突触钙级联机制:物质状态预测
《建模与仿真》2024年第4期4460-4470,共11页陈彦东 
小脑的运动学习记忆所涉及的PF-PC突触权重变化被称为钙级联机制,这种机制利用化学受体磷酸化和去磷酸化的动态调节作用来模拟突触权重的变化。鉴于钙级联涉及多种化学物质组成的复杂动力学系统,在计算刺激信号是随机输入的视动反应时...
关键词：运动记忆 钙级联 IP3 CAMKII 
Corrigendum to“Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca^(2+)/CaMKII pathway”[J.Pharm.Anal.14(2024)435–438]
《Journal of Pharmaceutical Analysis》2024年第6期933-933,共1页Congyu Ma Ning Sheng Jun Wu Lulu Wang Jiandong Jiang Haibo Yu Jinlan Zhang 
The authors regret there was an unfortunate error in the reproduction of Fig.1I in the article.In the original figure,the fluorescence picture of the positive control drug-ifenprodil was misused.The authors have corre...
关键词：correction Active PICTURE 
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