supported by grants-in-aid for Science from the Ministry of Education,Culture,Sports,Science and Technology of Japan(TH and IT).
Background:Mizoribine(MZR)is a selective inhibitor of inosine monophosphate dehydrogenase,a key enzyme in the pathway responsible for de novo synthesis of guanine nucleotides.As an immunosuppressant,MZR has been used ...
Background:Nephrotic syndrome is the most common cause of kidney disease in children,but its pathogenesis remains unclear.This article reviews the novel aspects of the mechanisms underlying massive proteinuria in mini...