MIZORIBINE

作品数：6被引量：10H指数：2
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相关领域：医药卫生更多>>
相关作者：王长希黄刚李军陈立中傅茜更多>>
相关机构：中山大学附属第一医院更多>>
相关期刊：《Chinese Medical Journal》《外科研究与新技术（中英文）》《国外新药介绍》《World Journal of Pediatrics》更多>>
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Usefulness of mizoribine administration in children with frequently relapsing nephrotic syndrome, and the relationship between pharmacokinetic parameters and efficacy: a multicenter prospective cohort study in China被引量：5
《World Journal of Pediatrics》2019年第3期262-269,共8页Zheng-Kun Xia Yuan-Fu Gao Li-Ping Rong Xi-Qiang Dang Qian Shen Xiao-Yun Jiang Zhu-Wen Yi Hong Xu 
Background Mizoribine (MZR) is an immunosuppressant used to treat adult nephropathy.There is little experience with the drug in treating Chinese children with frequently relapsing nephrotic syndrome (FRNS).We investig...
关键词：Frequently relapsing nephrotic syndrome MIZORIBINE PHARMACOKINETIC parameters 
Mizoribine in the treatment of pediatric-onset glomerular disease
《World Journal of Pediatrics》2015年第2期108-112,共5页Hiroshi Tanaka Kazushi Tsuruga Taddatsu Imaizumi 
supported by grants-in-aid for Science from the Ministry of Education,Culture,Sports,Science and Technology of Japan(TH and IT).
Background:Mizoribine(MZR)is a selective inhibitor of inosine monophosphate dehydrogenase,a key enzyme in the pathway responsible for de novo synthesis of guanine nucleotides.As an immunosuppressant,MZR has been used ...
关键词：macrophage infiltration mesangial cells MIZORIBINE monocyte chemoattractant protein-1 PODOCYTES 
Mizoribine versus mycophenolate mofetil or intravenous cyclophosphamide for induction treatment of active lupus nephritis被引量：4
《Chinese Medical Journal》2014年第21期3718-3723,共6页Feng Xuebing Gu Fei Chen Weiwei Liu Yan Wei Hua Liu Lin Yin Songlou Da Zhanyun Sun Lingyun 
Background Lupus nephritis （LN） is one of the most serious manifestations of systemic lupus erythematosus.Although there have been substantial improvements in LN treatment over the last decade,the outcome remains un...
关键词：MIZORIBINE mycophenolate mofetil CYCLOPHOSPHAMIDE lupus nephritis 
The ATPase activity of molecular chaperone HSP60 is inhibited by immunosuppressant mizoribine被引量：1
《American Journal of Molecular Biology》2012年第2期93-102,共10页Masako Tanabe Ryuichi Ishida Fumiko Izuhara Atsushi Komatsuda Hideki Wakui Kenichi Sawada Michiro Otaka Nobuhiro Nakamura Hideaki Itoh 
The molecular chaperone HSP60 is a chaperonin homolog of GroEL. We had previously shown that the immunosuppressant mizoribine is bound directly to HSP60 and inhibited its chaperone activity. However, the inhibitory me...
关键词：HSP60 GROEL MIZORIBINE INHIBITION MECHANISMS Conformational Change 
Application of various doses of mizoribine in clinical kidney transplantation
《外科研究与新技术》2011年第4期282-283,共2页陈怀周 
Objective To observe efficacy and safety of different doses of mizoribine to prevent rejection after renal transplantation. Methods Sorted by time of operation and odevity,206 primary kidney transplant recipients were...
关键词：MMF 
多发性硬化症治疗剂
《国外新药介绍》1996年第2期3-5,共3页
关键词：多发性硬化症 药物疗法 MIZORIBINE 
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