Lipopolysaccharides(LPS)are outer membrane components of Gram-negative bacteria made of three regions:the O-antigen;the core oligosaccharide;and a glucosamine disaccharide linked to hydroxy fatty acids,which is named ...
Supported by Beijing Natural Science Foundation of China(Investigation of the Mechanism on Qingdu Decoction in Repairing Injured Liver with TAA in Rat Based on Decreasing Intestinal Permeability,No.7142023)
OBJECTIVE: To investigate the protective effects and underlying mechanism of Qingdu decoction(QDD) on experimental rats with severe liver injury induced by thioacetamide(TAA).METHODS: A total of 40 Wistar rats were ra...
supported by grants from the Brazilian Agency Coordination of Graduate Level Training(CAPES,project 0366/09-9);State of So Paulo Research Support Foundation(FAPESP-Brazil,project 2005/60159-7)
Endotoxins(also known as lipopolysaccharides(LPS)) are undesirable by-products of recombinant proteins,purified from Escherichia coli.LPS can be considered stable under a wide range of temperature and pH,making their ...
grants from the Japanese Society for the Promotion of Science(no.17590776 to HK and no.17790524 to MY).
Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess ...
Project was supported by the National Natural Science Foundation of China(№ 39170877,39800193,and 39870872);the Foundation of Ministry of Health People's Republic of China(No 98-2-110)
Aim:To study the anti-endotoxic effect of o-aminobenzoic acid(OABA)isolated from Banlangen(BLG).Methods:OABA was extracted and isolated from BLG and diluted into 0.5% solution.The concentration of endotoxin(ET)pretrea...
Project supported by Fujian Provincial Science Foundation;No 2001Z029.
AIM: To study the preventive effect of recombinant human fibronectin (rhFN) polypeptide on hepatic failure in- duced by endotoxin in mice. METHODS: A cDNA fragment coding for Ile1363-Tyr1725 of human FN was inserted...
AIM: To study the effects of endotoxin on portal hemodynamic of normal and noncirrhotic portal hypertensive rats. METHODS: Normal rats were intraperitoneally injected with 0.1, 0.25, 0.5, 1.0, 2.0, 4.0mg.kg(-1) of lip...
the key,project of the tenth-five foundation of PLA,No.01Z011
AIM: Critical illnesses such as sepsis, trauma, and burns cause a growth hormone insensitivity, which leads to an increased negative nitrogen balance. Endotoxin is generously released into blood under these conditions...
Project supported by Natural Science Foundation of Jiangsu Province,No BK99158
To investigate the mechanism of growth hormone (GH) insensitivity induced by endotoxin at receptor and post-receptor levels. METHODS: Sprague-Dawley rats were injected endotoxin along with or without GH administration...
Objective:: To evaluate activation of P38 mitogen-activated protein kinase (P38MAPK) in alveolar macrophage (AM), release of TNFα and NO from cells, and their relationship following lipopolysacchride (LPS) stimulatio...