Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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  • 期刊=Neural Regeneration Researchx
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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease
《Neural Regeneration Research》2025年第1期174-180,共7页Yinglong Miao Michael S.Wolfe 
supported in part by Award 2121063 from National Science Foundation(to YM);AG66986 from the National Institutes of Health(to MSW).
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...
关键词：Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH 
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease
《Neural Regeneration Research》2022年第1期31-37,共7页Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre 
supported by the Consejo Nacional de Ciencia y Tecnología Scholarship 711893(to MAH)and 711874(to EER)。
The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressiv...
关键词：familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex 
Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells
《Neural Regeneration Research》2014年第21期1923-1928,共6页Guangzhe Li Hui Chen Lin Cheng Rongjie Zhao Junchang Zhao Yanji Xu 
supported by the Natural Science Foundation of Technology Gallery in Jilin Province of China,No.2011-15237;the National Natural Science Foundation of China,No.81160159
The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secret-ing inlfammatory cytokines, and is an important target in the treatment of nerve inlfammation and neurodegenerative di...
关键词：nerve regeneration NEURODEGENERATION Alzheimer’s disease APLP2 S100A9 C-terminal fragments amyloid precursor protein BV2 cells Γ-SECRETASE NSFC grant neural regeneration 
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rats
《Neural Regeneration Research》2010年第5期353-357,共5页Xiaojuan Wang Hong Liu Liang Li 
the Natural Science Foundation of Bei-jing, No. 7073088
BACKGROUND： Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer＇s disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. ...
关键词：chronic cerebral hypoperfusion Β-AMYLOID Β-SECRETASE Γ-SECRETASE Alzheimer＇s disease brain injury neural regeneration 
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