Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives被引量：8
《Science China(Life Sciences)》2021年第6期926-937,共12页Bin-Lu Sun Yang Chen Dong-Yu Fan Chi Zhu Fan Zeng Yan-Jiang Wang 
supported by the National Natural Science Foundation of China(91749206,81930028,81625007,81870860,31921003)。
Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.There...
关键词：Alzheimer's disease amyloidβ immunotherapy Β-SECRETASE Γ-SECRETASE enzyme inhibitor multi-target therapy tertiary prevention strategy 
Physalin B reduce secretion of Aβ by inhibiting phosphorylation of STAT3 via down-regulated expression of β-secretase and γ-secretase
《中国药理学与毒理学杂志》2019年第6期426-427,共2页BAI Shan-shan ZHUO Lin SUN Yi SHI Ru-ling XIE Yong-sheng ZHANG Wei 
National Natural Science Foundation(U1604108);Key Science and Technology Program of Henan Province(152102310112; 162102310121);National Training Program of Innovation for Undergraduates(201710472009)
OBJECTIVE Extracellular amyloid-β(Aβ) plaques are one of the major pathological hallmarks of Alzheimer disease(AD). Therefore, decreasing Aβ levels is one strategyfor preventing the etiology of AD. Aβ peptides are...
关键词：Alzheimer disease PHYSALIN B Β-AMYLOID protein BACE1 PS1 STAT3 
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rats
《Neural Regeneration Research》2010年第5期353-357,共5页Xiaojuan Wang Hong Liu Liang Li 
the Natural Science Foundation of Bei-jing, No. 7073088
BACKGROUND： Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer＇s disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. ...
关键词：chronic cerebral hypoperfusion Β-AMYLOID Β-SECRETASE Γ-SECRETASE Alzheimer＇s disease brain injury neural regeneration 
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