supported by the National Program on the Key Research Project of China(2022YFC2604201);the European Union’s Horizon 2020 Research and Innovation Programme(861917–SAFFI);the Zhejiang Provincial Natural Science Foundation of China(LR19C180001);the Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City(2021JJLH0083);the Zhejiang Provincial Key R&D Program of China(2023C03045,2022C02024 and 2021C02008);the Open Project Program of the Jiangsu Key Laboratory of Zoonosis(R1902)。
Understanding changes in pathogen behavior(e.g.increased virulence,a shift in transmission channel)is critical for the public health management of emerging infectious diseases.Genome degradation via gene depletion or ...
the National Center for Protein Sciences at Peking University for assistance with Amersham Imager;and Guilan Li for help with cDNA library.The work was supported by the National Key Research and Development Program of China(2017YFA0505200 and 2016YFC0906000 to J.X.;2019YFA0508904 to N.G.);the National Science Foundation of China(31570735 and 31822014 to J.X.;31725007 and 31630087 to N.G.);the Qidong-SLS Innovation Fund to J.X.and N.G.;and the Clinical Medicine Plus X Project of Peking University to J.X.
Secretory Immunoglobulin A(SIgA)is the most abundant antibody at the mucosal surface.It possesses two additional subunits besides IgA:the joining chain(J-chain)and secretory component(SC).SC is the ectodomain of the p...
National Natural Science Foundation of China(Nos.31700706,21877052);Natural Science Foundation of Jiangsu Province(No.BK20180030);the Fundamental Research Funds for the Central Universities(No.JUSRP51712B);the Public Health Research Center at Jiangnan University(No.JUPH201502);Max Planck Society International Partner Group Program;High-end Foreign Experts Recruitment Program;the Thousand Talents Plan(Young Professionals);the China Scholarship Council.
The rapid detection of pathogenic bacteria is vital for the prevention of outbreaks of infectious diseases, including infections by the common foodborne bacteria E.coli and Salmonella Carbohydrate microarrays have bee...
This study evaluated biofilm formation and antibiotic susceptibility in 36 clinical S. aureus isolates recovered from orthopaedic patients and detected the presence of intercellular adhesion and adhesin genes. Staphyl...
Renate Lux was supported by National Institute of Health,National Institute of Dental and Craniofacial Research DE021108 and DE018276;Jane Park was supported by NIDCR grant 5T90DE022734-02
Bacterial adherence is an essential virulence factor in pathogenesis and infection. Fusobacterium nucleatum has a central role in oral biofilm architecture by acting as a bridge between early Gram-positive and late Gr...
This research work was fimded by the Natural Science Foundation of Shanghai from the Science and Technology Commission of Shanghai Municipality (No. 14ZR1405700).
This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The...
Mycoplasma hominis is a member of the genus mycoplasma and has only been isolated from humans. It is most frequently isolated from the urogenital tract in the absence of symptoms, but has been isolated from wounds, br...
supported by the National Basic Research Program(973 Program)(Nos.2011CB910502 and 2012CB911101);National Natural Science Foundation of China(Grant Nos.31030020 and 31170679).
Staphylococcus aureus is the most important Gram-positive colonizer of human skin and nasal passage,causing high morbidity and mortality.SD-repeat containing protein D(SdrD),an MSCRAMM(Microbial Surface Components Rec...
To test the possibility of producing the novel vaccine in plants against diarrhea normally found in neonatal and newly weaned piglets, the faeG gene, encoding a major F4ac fimbrial subunit protein, was introduced into...