Background:Calcium regulatory proteins-L-type Ca^2+ channels (LTCCs),ryanodine receptor 2 (RyR2),and Na^+/Ca^2+ exchanger isoform 1 (NCX1) have been recognized as important protective mechanisms during myoca...
This study wassupported by grants from the Natural Science Foundation Project of Hubei Province (No. 2004ABA234), Wuhan Morning Program Project (No. 200850731390), and Project of Wuhan Clinical Medical Research Center in Children's Neural Disease (No. 2014-160).
Background: Na^+/Ca^2+ exchanger (NCX) plays a crucial role in pentylenetetrazol-induced convulsion. However, it is unclear whether NCX is critically involved in hyperthermia-induced convulsion. In this study, we...
This work was supported by the National Natural Science Foundation of China (Grant No. 81173625, 81373458) Thanks for the kind help of Dr. Wang (Pulmonary Division, Boston Children's Hospital, MA, USA), who was extremely helpful in the revision of the language.
Background The mitochondrial Na^+/Ca^2+ exchanger, NCLX, plays an important role in the balance between Ca2. influx and efflux across the mitochondrial inner membrane in endothelial ceils. Mitochondrial metabolism i...
Powered by the mitochondrial membrane potential,Ca2+ permeates the mitochondria via a Ca2+ channel termed Ca2+ uniporter and is pumped out by a Na+/Ca2+ exchanger,both of which are located on the inner mitochondrial m...
This work was supported bygrants from the National Natural Science Foundation of China (No. 30900646) and the National Science Foundation of China (No. 81241004). Conflict of interest: None.
Background Recent studies showed the central Na+/H+ exchanger type 3 (NHE3) has a close relationship with ventilation control.The objective of the study is to investigate the role of NHE3 in sleep apnea in Sprague...
Financial support for this research was provided by the Ministry of Science and Technology of China,the National Natural Science Foundation of China,the Fundamental Research Funds for the Central Universities,the Program for New Century Excellent Talents in the Ministry of Education in China
Populus euphratica Olivier and P. pruinosa Schrenk are known for their tolerance to highly saline and arid habitats, and overlapping distribution. We examined interspecific differentiation and gene flow between these ...
To investigate the reverse mode function of Na*/Ca2~ exchangers NCXI.1 and NCX1.5 expressed in CHO cells as well as their modulations by PKC and PKA. Methods: CHO-K1 cells were transfected with pcDNA3.1 (+) plasm...