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Shedding light on the retina to see healthy and pathological aging
《Neural Regeneration Research》2025年第12期3537-3538,共2页Marília Inês Móvio Maria Camila Almeida Sergio T.Ferreira Alexandre Hiroaki Kihara 
With the advances in medicine and technology,life expectancy has increased significantly in recent decades.While this is positive news,it also brings major challenges to public health systems.As people live longer,the...
关键词：DISEASES ALZHEIMER cases 
Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds
《Neural Regeneration Research》2025年第4期1009-1014,共6页Antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa 
supported by Telethon Italy award GGP15225(to RC and GM);Italian Ministry of Health award RF-2016-02362950(to RC and CZ);the CJD Foundation USA(to RC);the Associazione Italiana Encefalopatie da Prioni(AIEnP)(to RC).
PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other mammals.PrPSccan adopt different patho...
关键词：anti-prion drug anti-PrPC antibody antisense oligonucleotide NEURODEGENERATION pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor 
Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain:from theory to facts被引量：2
《Neural Regeneration Research》2023年第9期1869-1875,共7页Andreu Matamoros-Angles Behnam Mohammadi Feizhi Song Mohsin Shafiq Santra Brenna Berta Puig Markus Glatzel Hermann C.Altmeppen 
supported by funding from the Creutzfeldt-Jakob Disease Foundation;Inc.(USA);the Alzheimer Forschung Initiative (AFI e.V.,Germany);the Werner-Otto-Stiftung (Hamburg,Germany)(all to HCA);the China Scholarship Council (to FS);European Union’s Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie Grant Agreement N°101030402 (to AMA);Deutsche Forschungsgemeinschaft (DFG) Collaborative Research Center (CRC) 877"Proteolysis as a regulatory event in pathophysiology"(to MG)。
In the last decades,the role of the prion protein(PrP) in neurodegenerative diseases has been intensively investigated,initially in prion diseases of humans(e.g., Creutzfeldt-J akob disease) and animals(e.g.,scrapie i...
关键词：ADAM10 aggregation Alzheimer’s disease AMYLOID antibodies Creutzfeldt-Jakob disease enzymatic cleavage extracellular vesicles NEURODEGENERATION NEUROTOXICITY proteolytic processing stroke transmissible spongiform encephalopathies 
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